Research on the Role of Natural Bioactives in Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025
Special Issue Editor
Interests: gastroenterology; hepatology; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The increasing prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a significant public health concern. With lifestyles becoming more sedentary and diets increasingly featuring processed foods, the global incidence of MASLD is rising. Despite this worrying trend, there remains a substantial gap in understanding the role of natural bioactives in preventing and managing this condition, making this Special Issue particularly timely and crucial.
This Special Issue aims to explore the diverse role of natural bioactives in combating MASLD from a nutritional standpoint. We will highlight cutting-edge research that examines the biochemical pathways activated by these compounds. Furthermore, we will discuss the implications of various bioactive compounds in dietary practices and their potential to alleviate the effects of metabolic syndromes related to liver disease. The issue will also delve into the pathophysiology of MASLD, the connection between dietary habits and genetic factors, such as the PNPLA3 polymorphism, and the gut microbiome's influence on nutritional components.
This Special Issue will address vital existing gaps in the research concerning the role of natural bioactives in managing and preventing MASLD. By compiling high-quality research articles, reviews, and perspectives, we aim to create a comprehensive resource that informs practitioners and researchers while contributing to developing healthier dietary strategies for affected populations. We invite esteemed contributors to share their insights and help expand our understanding of this critical intersection between nutrition and liver health.
Dr. Muhammad Y. Sheikh
Guest Editor
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Keywords
- NAFLD (nonalcoholic fatty liver disease)
- MASLD (metabolic syndrome-associated steatotic liver disease)
- metabolic syndrome
- dyslipidemia
- diabetes mellitus 2
- hypertension
- natural bioactive
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