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Molecular Research in Skin Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 801

Special Issue Editor


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Guest Editor
Department of Plastic Surgery and Reconstructive Microsurgery, “Sf. Spiridon” Emergency County Hospital Iasi, “Gr. T. Popa” University of Medicine and Pharmacy Iasi, Bulevardul Independentei No. 1, 700115 Iasi, Romania
Interests: hand surgery; reconstructive surgery; microsurgery; burns; nerve surgery; replantations; traumatology
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Special Issue Information

Dear Colleagues,

The skin, the body's largest organ, plays a crucial role in maintaining homeostasis. It serves defensive and immunological functions, acts as a reservoir of epithelial cells, and functions as a sensory organ. Through its color, appearance, and various changes, the skin often reflects a wide range of underlying pathologies, ranging from mild to severe. Additionally, the skin—particularly that of the face—is essential for expressing emotions and feelings. Given these diverse functions, preserving the skin’s health, both functionally and aesthetically, is a priority. Early recognition of changes is critical for effectively treating skin diseases. Collaboration between researchers and clinicians, as well as among various medical specialties, including dermatology, rheumatology, plastic surgery, and aesthetic medicine, is key to diagnosing rare diseases, developing innovative treatments to maintain skin health, and managing both common and rare skin conditions.

This Special Issue will bring together clinicians and researchers for developing new methods for maintaining healthy skin and studying methods of surgical or non-surgical treatment and associations between them and various malignant or benign skin lesions, dermatological pathologies or methods of healing or stimulating healing in cases of skin defects of various etiologies, including those that are hard to heal.

Dr. Mihaela Pertea
Guest Editor

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Keywords

  • wound healing
  • molecular research in skin lesions
  • dermatologic surgery
  • cosmetic surgery
  • exosomes: new molecular targets of diseases

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Published Papers (1 paper)

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Review

14 pages, 586 KB  
Review
Efficacy of Neoadjuvant Cemiplimab Treatment for Cutaneous Squamous Cell Carcinoma—A Systematic Review
by Maria Eduarda Palomba, Julia Adriana Karmirski and Flávio Carneiro Hojaij
Int. J. Mol. Sci. 2025, 26(16), 8109; https://doi.org/10.3390/ijms26168109 - 21 Aug 2025
Viewed by 519
Abstract
Skin cancer is the most common cancer form worldwide, and it is primarily divided into melanoma and non-melanoma types, with non-melanoma being the most prevalent condition. Cutaneous squamous cell carcinoma (cSCC) accounts for 50% of primary skin cancers and is characterized by uncontrolled [...] Read more.
Skin cancer is the most common cancer form worldwide, and it is primarily divided into melanoma and non-melanoma types, with non-melanoma being the most prevalent condition. Cutaneous squamous cell carcinoma (cSCC) accounts for 50% of primary skin cancers and is characterized by uncontrolled keratinocyte proliferation. cSCC’s current standard treatment is surgical resection and chemotherapy. Unfortunately, these methods often lead to disfigurement, functional morbiditly, and compromised function. In contrast to immunotherapy, emerging scenarios have shown promising results, especially in neoadjuvant settings. Cemiplimab (Libtayo®; Regeneron, Tarrytown, NY, USA), a PD-1 monoclonal antibody, has shown efficacy in treating advanced or metastatic cSCC, and its use as a neoadjuvant therapy has been recently explored. This review aims to evaluate Cemiplimab in the neoadjuvant setting for cSCC treatment. The Methodology followed PRISMA guidelines, this review analyzed studies on Cemiplimab as a neoadjuvant therapy for cSCC that were sourced from PubMed, Web of Science, and Scopus. Only controlled trials, cohort studies, case series, and systematic reviews were included. From 341 records, 21 studies were included, and six clinical trials provided key data about neoadjuvant Cemiplimab’s response rates, efficacy, adverse effects, and safety considerations. The targeted data revealed a neoadjuvant Cemiplimab mean pathologic response rate of 72%, with a 62% objective response rate. Treatment-related adverse events (TRAEs) affect 66% of patients, though most cases are not severe. The most common include fatigue, maculopapular rash, and diarrhea. The studies showed high rates of complete pathological responses (cPRs) and major pathological responses (mPRs), suggesting a strong therapeutic potential. Neoadjuvant Cemiplimab for cSCC therapy shows high response rates, low recurrence, improved survival, and manageable side effects. The current literature indicates that Cemiplimab may also be effective when used in immunosuppressed patients. Despite more research still being needed to confirm its long-term benefits and the effects of the drug’s use outside of clinical trials, there is strong evidence to consider neoadjuvant Cemiplimab as a promising and efficient treatment. Full article
(This article belongs to the Special Issue Molecular Research in Skin Health and Disease)
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