Amyotrophic Lateral Sclerosis Behind Motor Neurons
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 713
Special Issue Editors
Interests: apoptosis; inflammation; hydrogen sulfide; motor neuron; astrocytes
Interests: dopaminergic circuitry; neurodegeneration; cellular neuropathology; miRNA and dopaminergic phenotype; electrophysiology and microfluorometry; animal models of neurodegenerative disease; dopamine and Parkinson's disease; dopamine and early life social stress
Special Issue Information
Dear Colleagues,
Since its description by Jean-Martin Charcot in 1869, our knowledge of Amyotrophic Lateral Sclerosis (ALS), defined as a lethal neurodegenerative disease affecting both the upper and lower motoneurons, has widely increased. Although the primary cause remains the death of the motor neuron, increased understanding of disease pathophysiology has attested that ALS is a multisystem disorder affecting the brain and beyond. Indeed, the pathology involves the primary motor cortex spreading via axonal projections within motor and extramotor systems, including subcortical structures. A proportion of ALS patients display extramotor deficits (namely cognitive–behavioral disturbances, impaired ocular movements, and extrapyramidal alterations), which seem to correspond to the pathological involvement of the relevant cerebral structures. In addition, the crosstalk between neuronal and non-neuronal cells, and between peripheral organs and the central nervous system, is now established as an essential contributor to the neurodegenerative process.
This Special Issue of IJMS aims to focus on the contribution of areas of the brain behind the motor system and the motor neuron, including peripheral organs and the impact of an altered metabolism. ALS goes beyond motor neuron death, and this Special Issue aims to pinpoint this aspect of ALS pathology, collecting new insights underlying ALS as a multisystem disorder.
Your contribution to this Special Issue, either with original research or review articles, will be highly appreciated.
Prof. Dr. Patrizia Longone
Dr. Ezia Guatteo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- non-neuronal cells
- neurotransmitters
- systemic disease
- motor system
- neuronal circuitry
- skeletal muscle metabolism
- muscle oxidative metabolism
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
