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Bioactive Compounds of Natural Origin: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 637

Special Issue Editor


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Guest Editor
Department of Environment Hygiene and Animal Welfare, Faculty of Biology and Animal Science, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
Interests: plant extract; bioactive compounds; natural products
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Special Issue Information

Dear Colleagues,

Plants are a notable source of natural chemicals, with different structural and biological features that exhibit multifarious mechanisms of action. Various plant species contain myriad secondary metabolites that greatly influence their competitiveness in the environment and protection against adverse growth conditions. These substances are also known to greatly benefit humans and animals.

This Special Issue welcomes papers that address all the aspects related to natural products containing highly efficient and safe substances with long-term health effects. Manuscripts that facilitate the development and application of innovative products will be considered.

Dr. Katarzyna Pacyga
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • plants
  • extraction methods
  • bioactive compounds
  • natural products
  • application

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Published Papers (1 paper)

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Research

19 pages, 5696 KiB  
Article
Effects of Cnidium officinale, Pueraria lobata Ohwi, and Leonurus japonicus Extract on Vascular Endothelial Dysfunctions in Ovariectomized Rats and Molecular Mechanisms
by Joohee Oh, Minseo Kim, Jinsoo Kim, Jiwon Jang, Dongjin Noh and Hyun-Sook Kim
Int. J. Mol. Sci. 2025, 26(10), 4708; https://doi.org/10.3390/ijms26104708 - 14 May 2025
Viewed by 528
Abstract
Menopause is the natural period of aging in women induced by ovary deterioration, resulting in estrogen deficiency. We evaluated the antioxidative and anti-inflammatory properties of Cnidium officinale, Pueraria lobata Ohwi, and Leonurus japonicus (CPL) extracts on vascular endothelial dysfunction. After treatment, CPL [...] Read more.
Menopause is the natural period of aging in women induced by ovary deterioration, resulting in estrogen deficiency. We evaluated the antioxidative and anti-inflammatory properties of Cnidium officinale, Pueraria lobata Ohwi, and Leonurus japonicus (CPL) extracts on vascular endothelial dysfunction. After treatment, CPL extracts decreased serum lipid profiles, serum vasoactive substances, tail temperatures, and cardiovascular risk indices. In ovariectomized rats, vasodilation significantly increased, with an increase in endothelial nitric oxide synthase (eNOS) in the CPL200 and CPL500 groups compared with the OVX group (p < 0.05). The extracts also significantly reduced vascular cell adhesion protein 1 (VCAM-1) in the CPL50, CPL100, and CPL200 groups compared with the OVX group (p < 0.05, p < 0.01, and p < 0.001, respectively). Intercellular adhesion molecule 1 (ICAM-1) was also reduced in the CPL100 and CPL200 groups compared with the OVX group (p < 0.001 and p < 0.0001, respectively); this was achieved through the downregulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and inducible nitric oxide (iNOS), which resulted in the synthesis of nuclear factor erythroid 2-related factor 2 (NRF2) and eNOS in HUVECs. Our results show that CPL extracts could provide cardioprotective effects against vascular endothelium dysfunction by decreasing inflammation and upregulating vasodilation, ascertained by evaluating the antioxidant systems of ovariectomized rats. Further studies are needed to explore the long-term cardioprotective effects. Full article
(This article belongs to the Special Issue Bioactive Compounds of Natural Origin: 2nd Edition)
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