Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

Dear Colleagues,

Amyotrophic Lateral Sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by progressive paralysis and death, usually due to respiratory failure. Despite significant advancements in understanding ALS pathomechanisms over the past decades, its exact cause remains unknown, and no effective treatment is currently available. As a result, ALS continues to be a major focus of scientific research.

This Special Issue aims to collect both original research and review articles exploring innovative pathomechanisms and potential therapeutic targets, such as:

(1) Novel candidate genes and gene-specific therapeutic approaches

(2) Epigenetic mechanisms in ALS pathogenesis

(3) Innovative disease models for ALS research

(4) Neuroinflammatory and immune system contributions to ALS progression

(5) Mitochondrial dysfunction and oxidative stress as key pathogenic factors

We welcome contributions that offer new insights into these topics, helping to advance our understanding of ALS and uncover potential therapeutic strategies.

Dr. Matteo Bordoni
Guest Editor

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