Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 1729
Special Issue Editor
Interests: neurodegeneration; ALS; cellular models; iPSCs; 3D bioprinting; organoids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Amyotrophic Lateral Sclerosis (ALS) is one of the most common neurodegenerative diseases, characterized by progressive paralysis and death, usually due to respiratory failure. Despite significant advancements in understanding ALS pathomechanisms over the past decades, its exact cause remains unknown, and no effective treatment is currently available. As a result, ALS continues to be a major focus of scientific research.
This Special Issue aims to collect both original research and review articles exploring innovative pathomechanisms and potential therapeutic targets, such as:
(1) Novel candidate genes and gene-specific therapeutic approaches
(2) Epigenetic mechanisms in ALS pathogenesis
(3) Innovative disease models for ALS research
(4) Neuroinflammatory and immune system contributions to ALS progression
(5) Mitochondrial dysfunction and oxidative stress as key pathogenic factors
We welcome contributions that offer new insights into these topics, helping to advance our understanding of ALS and uncover potential therapeutic strategies.
Dr. Matteo Bordoni
Guest Editor
Manuscript Submission Information
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Keywords
- ALS
- pathomechanisms
- genetics
- epigenetics
- disease models
- neuroinflammation
- mithocondria
- oxidative stress
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