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Fungal Pathogen-Host Interactions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1839

Special Issue Editor


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Guest Editor
Laboratory of Molecular Biology of Pathogenic Fungi, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil
Interests: molecular mycology; microbiology; pathogens; mycology; medical mycology; fungi; fungal biology; immunology

Special Issue Information

Dear Colleagues,

The upcoming special issue of IJMS focuses on “Fungal Pathogen-Host Interactions”, particularly the interactions between immune cells and human pathogenic fungi. We seek manuscripts exploring the dynamic interplay between immune cells like macrophages, neutrophils, and dendritic cells with fungi such as Candida spp., Aspergillus spp., and Cryptococcus spp. Studies using advanced immunological, molecular, transcriptomic, or genomic techniques are highly encouraged.

We also welcome research on the fungal and host genes involved in these interactions, with an emphasis on virulence factors and genetic remodeling post-interaction. This Issue aims to deepen our understanding of the molecular and cellular mechanisms of fungal infections and foster the development of innovative therapeutic strategies.

Dr. Patricia Albuquerque
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medical mycology
  • host–microbe interactions
  • macrophages
  • dendritic cells
  • neutrophils

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Published Papers (1 paper)

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Research

24 pages, 9508 KiB  
Article
From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with Different Candida albicans Extracellular Vesicles
by Raquel Martínez-López, Gloria Molero, Claudia Marcela Parra-Giraldo, Matías Sebastián Cabeza, Guillermo Castejón, Carmen García-Durán, Luis Felipe Clemente, María Luisa Hernáez, Concha Gil and Lucía Monteoliva
Int. J. Mol. Sci. 2025, 26(1), 244; https://doi.org/10.3390/ijms26010244 - 30 Dec 2024
Viewed by 1436
Abstract
Extracellular vesicles (EVs) from Candida albicans can elicit immune responses, positioning them as promising acellular vaccine candidates. We characterized EVs from an avirulent C. albicans cell wall mutant (ecm33Δ) and evaluated their protective potential against invasive candidiasis. EVs from the yeast [...] Read more.
Extracellular vesicles (EVs) from Candida albicans can elicit immune responses, positioning them as promising acellular vaccine candidates. We characterized EVs from an avirulent C. albicans cell wall mutant (ecm33Δ) and evaluated their protective potential against invasive candidiasis. EVs from the yeast (YEVs) and hyphal (HEVs) forms of the SC5314 wild-type strain were also tested, yielding high survival rates with SC5314 YEV (91%) and ecm33 YEV immunization (64%). Surprisingly, HEV immunization showed a dual effect, resulting in 36% protection but also causing premature death in some mice. Proteomic analyses revealed distinct profiles among the top 100 proteins in the different EVs, which may explain these effects: a shared core of 50 immunogenic proteins such as Pgk1, Cdc19, and Fba1; unique, relevant immunogenic proteins in SC5314 YEVs; and proteins linked to pathogenesis, like Ece1 in SC5314 HEVs. Sera from SC5314 YEV-immunized mice showed the highest IgG2a titers and moderate IL-17, IFN-γ, and TNF-α levels, indicating the importance of both humoral and cellular responses for protection. These findings highlight the distinct immunogenic properties of C. albicans EVs, suggesting their potential in acellular vaccine development while emphasizing the need to carefully evaluate pathogenic risks associated with certain EVs. Full article
(This article belongs to the Special Issue Fungal Pathogen-Host Interactions)
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