Antitumor Activity of Natural Products
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 926
Special Issue Editor
Interests: leukemia; lymphoma; solid tumors; antineoplastic agents; cell death induction; signal transduction; predictive biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vincristine, irinotecan, etoposide, and paclitaxel are examples of plant-derived compounds that are being employed in cancer treatment, and dactinomycin, bleomycin, and doxorubicin are anticancer agents derived from microbial sources. Cytarabine is an example of an anticancer agent originating from a marine source. Recently, some products of natural origin were reclassified as targeted drugs, e.g., alvocidib (flavopiridol), which acts as a CDK9 inhibitor; staurosporine, which acts as a precursor of the novel protein kinase inhibitor midostaurin, as well as many other examples. It can be expected that natural products with lower toxicity may serve as a source of new antitumor drugs with preferential pharmacological properties against different types of cancer in humans. Additionally, natural products may contribute to a reduction in or the amelioration of the side effects of contemporary antineoplastic therapy. In this Special Issue, we invite authors to present their achievements in this research area of great interest. Studies on the molecular mechanisms of the antineoplastic activity of known and new natural products are welcome to be submitted. High-quality chemical and pharmacological analyses are also welcome, as these may lead to the specific discovery of synergistic interactions between different naturally occurring compounds in plant and animal extracts.
Prof. Dr. Spiro Mihaylov Konstantinov
Guest Editor
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Keywords
- natural compounds and extracts with antitumor activity
- studies on molecular mechanisms
- signal transduction modulation in tumor cells
- immunomodulating activity
- mitosis inhibition
- cell differentiation
- cell death induction (apoptosis/autophagy)
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