Skip Content
You are currently on the new version of our website. Access the old version .

Most Cited

  • Review
  • Open Access
495 Citations
90,320 Views
38 Pages

As healthcare systems around the world face challenges such as escalating costs, limited access, and growing demand for personalized care, artificial intelligence (AI) is emerging as a key force for transformation. This review is motivated by the urg...

  • Review
  • Open Access
383 Citations
41,217 Views
21 Pages

The integration of artificial intelligence (AI) into medical imaging has guided in an era of transformation in healthcare. This literature review explores the latest innovations and applications of AI in the field, highlighting its profound impact on...

  • Review
  • Open Access
146 Citations
31,446 Views
42 Pages

Medical image segmentation plays a critical role in accurate diagnosis and treatment planning, enabling precise analysis across a wide range of clinical tasks. This review begins by offering a comprehensive overview of traditional segmentation techni...

  • Review
  • Open Access
132 Citations
22,684 Views
51 Pages

A Comprehensive Review on Synergy of Multi-Modal Data and AI Technologies in Medical Diagnosis

  • Xi Xu,
  • Jianqiang Li,
  • Zhichao Zhu,
  • Linna Zhao,
  • Huina Wang,
  • Changwei Song,
  • Yining Chen,
  • Qing Zhao,
  • Jijiang Yang and
  • Yan Pei

Disease diagnosis represents a critical and arduous endeavor within the medical field. Artificial intelligence (AI) techniques, spanning from machine learning and deep learning to large model paradigms, stand poised to significantly augment physician...

  • Article
  • Open Access
127 Citations
9,334 Views
20 Pages

Green Synthesis of Magnesium Oxide Nanoparticles by Using Abrus precatorius Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities

  • Saheb Ali,
  • Kattakgoundar Govindaraj Sudha,
  • Natesan Thirumalaivasan,
  • Maqusood Ahamed,
  • Saravanan Pandiaraj,
  • Vijayarangan Devi Rajeswari,
  • Yamini Vinayagam,
  • Muthu Thiruvengadam and
  • Rajakumar Govindasamy

The current research is concerned with the synthesis of magnesium oxide (MgO) nanoparticles (NPs) from Abrus precatorius L. bark extract via the green chemistry method. The synthesized MgO NPs was confirmed by using several characterization methods l...

  • Review
  • Open Access
126 Citations
23,523 Views
48 Pages

Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends

  • Giovanni Chiarion,
  • Laura Sparacino,
  • Yuri Antonacci,
  • Luca Faes and
  • Luca Mesin

Understanding how different areas of the human brain communicate with each other is a crucial issue in neuroscience. The concepts of structural, functional and effective connectivity have been widely exploited to describe the human connectome, consis...

  • Article
  • Open Access
113 Citations
9,568 Views
23 Pages

Metaverse and Healthcare: Machine Learning-Enabled Digital Twins of Cancer

  • Omid Moztarzadeh,
  • Mohammad (Behdad) Jamshidi,
  • Saleh Sargolzaei,
  • Alireza Jamshidi,
  • Nasimeh Baghalipour,
  • Mona Malekzadeh Moghani and
  • Lukas Hauer

Medical digital twins, which represent medical assets, play a crucial role in connecting the physical world to the metaverse, enabling patients to access virtual medical services and experience immersive interactions with the real world. One serious...

  • Review
  • Open Access
101 Citations
19,741 Views
30 Pages

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

  • Harshita Tiwari,
  • Nilesh Rai,
  • Swati Singh,
  • Priyamvada Gupta,
  • Ashish Verma,
  • Akhilesh Kumar Singh,
  • Kajal,
  • Prafull Salvi,
  • Santosh Kumar Singh and
  • Vibhav Gautam

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis and treatment. Nanomaterials are extensively employed in the field of oncology because of their minute size and ultra-specificit...

  • Review
  • Open Access
84 Citations
27,376 Views
34 Pages

Chlorella sp. and Spirulina (Arthrospira) sp. account for over 90% of the global microalgal biomass production and represent one of the most promising aquiculture bioeconomy systems. These microorganisms have been widely recognized for their nutritio...

  • Review
  • Open Access
84 Citations
16,755 Views
33 Pages

Nano-Biofertilizer Formulations for Agriculture: A Systematic Review on Recent Advances and Prospective Applications

  • Diksha Garg,
  • Kandi Sridhar,
  • Baskaran Stephen Inbaraj,
  • Prince Chawla,
  • Manikant Tripathi and
  • Minaxi Sharma

In the twenty-first century, nanotechnology has emerged as a potentially game-changing innovation. Essential minerals are mostly unavailable in modern cropping systems without the application of synthetic fertilizers, which have a serious negative im...

  • Review
  • Open Access
79 Citations
12,855 Views
15 Pages

Advancements in biological wastewater treatment with sustainable and circularity approaches have a wide scope of application. Biological wastewater treatment is widely used to remove/recover organic pollutants and nutrients from a diverse wastewater...

  • Article
  • Open Access
74 Citations
10,299 Views
10 Pages

The opacity of deep learning makes its application challenging in the medical field. Therefore, there is a need to enable explainable artificial intelligence (XAI) in the medical field to ensure that models and their results can be explained in a man...

  • Systematic Review
  • Open Access
68 Citations
24,920 Views
15 Pages

Analysis of Dental Enamel Remineralization: A Systematic Review of Technique Comparisons

  • Giuseppina Malcangi,
  • Assunta Patano,
  • Roberta Morolla,
  • Matteo De Santis,
  • Fabio Piras,
  • Vito Settanni,
  • Antonio Mancini,
  • Daniela Di Venere,
  • Francesco Inchingolo and
  • Angelo Michele Inchingolo
  • + 2 authors

The demineralization process conditions the structure of the enamel and begins with a superficial decalcification procedure that makes the enamel surface porous and gives it a chalky appearance. White spot lesions (WSLs) are the first clinical sign t...

  • Article
  • Open Access
67 Citations
15,207 Views
16 Pages

Early diagnosis and classification of arrhythmia from an electrocardiogram (ECG) plays a significant role in smart healthcare systems for the health monitoring of individuals with cardiovascular diseases. Unfortunately, the nonlinearity and low ampli...

  • Article
  • Open Access
66 Citations
12,005 Views
17 Pages

Vision–Language Model for Visual Question Answering in Medical Imagery

  • Yakoub Bazi,
  • Mohamad Mahmoud Al Rahhal,
  • Laila Bashmal and
  • Mansour Zuair

In the clinical and healthcare domains, medical images play a critical role. A mature medical visual question answering system (VQA) can improve diagnosis by answering clinical questions presented with a medical image. Despite its enormous potential...

  • Article
  • Open Access
62 Citations
5,195 Views
21 Pages

Design and Analysis of a Deep Learning Ensemble Framework Model for the Detection of COVID-19 and Pneumonia Using Large-Scale CT Scan and X-ray Image Datasets

  • Xingsi Xue,
  • Seelammal Chinnaperumal,
  • Ghaida Muttashar Abdulsahib,
  • Rajasekhar Reddy Manyam,
  • Raja Marappan,
  • Sekar Kidambi Raju and
  • Osamah Ibrahim Khalaf

Recently, various methods have been developed to identify COVID-19 cases, such as PCR testing and non-contact procedures such as chest X-rays and computed tomography (CT) scans. Deep learning (DL) and artificial intelligence (AI) are critical tools f...

  • Review
  • Open Access
62 Citations
10,370 Views
16 Pages

Silver Nanoparticles in Dental Applications: A Descriptive Review

  • Sreekanth Kumar Mallineni,
  • Srinivasulu Sakhamuri,
  • Sree Lalita Kotha,
  • Abdul Rahman Gharamah M. AlAsmari,
  • Galiah Husam AlJefri,
  • Fatmah Nasser Almotawah,
  • Sahana Mallineni and
  • Rishitha Sajja

Silver nanoparticles have been a recent focus of many researchers in dentistry, and their potential uses and benefits have drawn attention in dentistry and medicine. The fabrication and utilization of nanoscale substances and structures are at the co...

  • Article
  • Open Access
61 Citations
4,293 Views
19 Pages

Exploring the Antimicrobial, Anticancer, and Apoptosis Inducing Ability of Biofabricated Silver Nanoparticles Using Lagerstroemia speciosa Flower Buds against the Human Osteosarcoma (MG-63) Cell Line via Flow Cytometry

  • Kariyellappa Nagaraja Shashiraj,
  • Anil Hugar,
  • Raju Suresh Kumar,
  • Muthuraj Rudrappa,
  • Meghashyama Prabhakara Bhat,
  • Abdulrahman I. Almansour,
  • Karthikeyan Perumal and
  • Sreenivasa Nayaka

Biosynthesized nano-composites, such as silver nanoparticles (AgNPs), can be engineered to function as smart nano-biomedicine platforms for the detection and management of diverse ailments, such as infectious diseases and cancer. This study determine...

  • Review
  • Open Access
60 Citations
7,454 Views
26 Pages

This review examines the increasing application of artificial intelligence (AI) and/or machine learning (ML) in microalgae processes, focusing on their ability to improve production efficiency, yield, and process control. AI/ML technologies are used...

  • Review
  • Open Access
60 Citations
12,794 Views
16 Pages

Global pollution from fossil plastics is one of the top environmental threats of our time. At their end-of-life phase, fossil plastics, through recycling, incineration, and disposal result in microplastic formation, elevated atmospheric CO2 levels, a...

  • Article
  • Open Access
58 Citations
2,670 Views
23 Pages

Radiomics and Deep Features: Robust Classification of Brain Hemorrhages and Reproducibility Analysis Using a 3D Autoencoder Neural Network

  • Salar Bijari,
  • Sahar Sayfollahi,
  • Shiwa Mardokh-Rouhani,
  • Sahar Bijari,
  • Sadegh Moradian,
  • Ziba Zahiri and
  • Seyed Masoud Rezaeijo

This study evaluates the reproducibility of machine learning models that integrate radiomics and deep features (features extracted from a 3D autoencoder neural network) to classify various brain hemorrhages effectively. Using a dataset of 720 patient...

  • Review
  • Open Access
57 Citations
14,966 Views
32 Pages

Silk Fibroin Materials: Biomedical Applications and Perspectives

  • Giuseppe De Giorgio,
  • Biagio Matera,
  • Davide Vurro,
  • Edoardo Manfredi,
  • Vardan Galstyan,
  • Giuseppe Tarabella,
  • Benedetta Ghezzi and
  • Pasquale D’Angelo

The golden rule in tissue engineering is the creation of a synthetic device that simulates the native tissue, thus leading to the proper restoration of its anatomical and functional integrity, avoiding the limitations related to approaches based on a...

  • Review
  • Open Access
54 Citations
15,773 Views
18 Pages

The utilization of lasers has been regarded as a novel technique for the purposes of clinical use in the dental field. Recently, numerous studies have been conducted on the potential applications of laser therapy in endodontics. Moreover, due to thei...

  • Article
  • Open Access
53 Citations
4,200 Views
20 Pages

AHANet: Adaptive Hybrid Attention Network for Alzheimer’s Disease Classification Using Brain Magnetic Resonance Imaging

  • T. Illakiya,
  • Karthik Ramamurthy,
  • M. V. Siddharth,
  • Rashmi Mishra and
  • Ashish Udainiya

Alzheimer’s disease (AD) is a progressive neurological problem that causes brain atrophy and affects the memory and thinking skills of an individual. Accurate detection of AD has been a challenging research topic for a long time in the area of...

  • Review
  • Open Access
53 Citations
13,543 Views
20 Pages

Cardiovascular diseases are the leading cause of morbidity and mortality in the United States. Cardiac tissue engineering is a direction in regenerative medicine that aims to repair various heart defects with the long-term goal of artificially rebuil...

  • Article
  • Open Access
52 Citations
5,335 Views
25 Pages

Histopathological Analysis for Detecting Lung and Colon Cancer Malignancies Using Hybrid Systems with Fused Features

  • Mohammed Al-Jabbar,
  • Mohammed Alshahrani,
  • Ebrahim Mohammed Senan and
  • Ibrahim Abdulrab Ahmed

Lung and colon cancer are among humanity’s most common and deadly cancers. In 2020, there were 4.19 million people diagnosed with lung and colon cancer, and more than 2.7 million died worldwide. Some people develop lung and colon cancer simulta...

  • Article
  • Open Access
52 Citations
6,353 Views
26 Pages

Optimization System Based on Convolutional Neural Network and Internet of Medical Things for Early Diagnosis of Lung Cancer

  • Yossra Hussain Ali,
  • Varghese Sabu Chooralil,
  • Karthikeyan Balasubramanian,
  • Rajasekhar Reddy Manyam,
  • Sekar Kidambi Raju,
  • Ahmed T. Sadiq and
  • Alaa K. Farhan

Recently, deep learning and the Internet of Things (IoT) have been widely used in the healthcare monitoring system for decision making. Disease prediction is one of the emerging applications in current practices. In the method described in this paper...

  • Review
  • Open Access
52 Citations
11,040 Views
32 Pages

Three-Dimensional Scaffolds for Bone Tissue Engineering

  • Harish Chinnasami,
  • Mohan Kumar Dey and
  • Ram Devireddy

Immobilization using external or internal splints is a standard and effective procedure to treat minor skeletal fractures. In the case of major skeletal defects caused by extreme trauma, infectious diseases or tumors, the surgical implantation of a b...

  • Article
  • Open Access
51 Citations
3,759 Views
17 Pages

Predictive Analysis of Hospital Stay after Caesarean Section: A Single-Center Study

  • Alfonso Maria Ponsiglione,
  • Teresa Angela Trunfio,
  • Francesco Amato and
  • Giovanni Improta

Caesarean section (CS) rate has seen a significant increase in recent years, especially in industrialized countries. There are, in fact, several causes that justify a CS; however, evidence is emerging that non-obstetric factors may contribute to the...

  • Review
  • Open Access
51 Citations
11,623 Views
21 Pages

Virtual Reality for the Rehabilitation of Acquired Cognitive Disorders: A Narrative Review

  • Valentina Catania,
  • Francesco Rundo,
  • Simonetta Panerai and
  • Raffaele Ferri

This review article explores the use of Virtual Reality (VR) technology in cognitive rehabilitation for individuals with neurological conditions, such as stroke, traumatic brain injury, and neurodegenerative diseases. The introduction highlights the...

  • Review
  • Open Access
50 Citations
8,412 Views
17 Pages

(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits

  • Dobromira Shopova,
  • Antoniya Yaneva,
  • Desislava Bakova,
  • Anna Mihaylova,
  • Petya Kasnakova,
  • Maria Hristozova,
  • Yordan Sbirkov,
  • Victoria Sarafian and
  • Mariya Semerdzhieva

The global development of technologies now enters areas related to human health, with a transition from conventional to personalized medicine that is based to a significant extent on (bio)printing. The goal of this article is to review some of the pu...

  • Review
  • Open Access
49 Citations
12,610 Views
27 Pages

Deep Learning-Based Reconstruction for Cardiac MRI: A Review

  • Julio A. Oscanoa,
  • Matthew J. Middione,
  • Cagan Alkan,
  • Mahmut Yurt,
  • Michael Loecher,
  • Shreyas S. Vasanawala and
  • Daniel B. Ennis

Cardiac magnetic resonance (CMR) is an essential clinical tool for the assessment of cardiovascular disease. Deep learning (DL) has recently revolutionized the field through image reconstruction techniques that allow unprecedented data undersampling...

  • Article
  • Open Access
49 Citations
5,955 Views
18 Pages

In the advancement of medical image super-resolution (SR), the Deep Residual Feature Distillation Channel Attention Network (DRFDCAN) marks a significant step forward. This work presents DRFDCAN, a model that innovates traditional SR approaches by in...

  • Review
  • Open Access
48 Citations
23,290 Views
11 Pages

Current Knowledge on the Healing of the Extraction Socket: A Narrative Review

  • Samuel E. Udeabor,
  • Anja Heselich,
  • Sarah Al-Maawi,
  • Ali F. Alqahtani,
  • Robert Sader and
  • Shahram Ghanaati

The concept of extraction socket healing has been severally researched and reported over the years, since tooth extraction remains one of the most common procedures performed in the dental clinic. Understanding this healing process is of utmost impor...

  • Article
  • Open Access
48 Citations
4,959 Views
13 Pages

A low-cost, fast, dependable, repeatable, non-invasive, portable, and simple-to-use vascular screening tool for coronary artery diseases (CADs) is preferred. Photoplethysmography (PPG), a low-cost optical pulse wave technology, is one method with thi...

  • Review
  • Open Access
47 Citations
8,196 Views
32 Pages

Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials

  • Paola Nitti,
  • Athira Narayanan,
  • Rebecca Pellegrino,
  • Stefania Villani,
  • Marta Madaghiele and
  • Christian Demitri

The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell–tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in...

  • Systematic Review
  • Open Access
47 Citations
7,836 Views
14 Pages

Mechanical Properties of Three-Dimensional Printed Provisional Resin Materials for Crown and Fixed Dental Prosthesis: A Systematic Review

  • Saeed J. Alzahrani,
  • Maher S. Hajjaj,
  • Amr Ahmed Azhari,
  • Walaa Magdy Ahmed,
  • Hanin E. Yeslam and
  • Ricardo Marins Carvalho

The emergence of digital dentistry has led to the introduction of various three-dimensional (3D) printing materials in the market, specifically for provisional fixed restoration. This study aimed to undertake a systematic review of the published lite...

  • Review
  • Open Access
47 Citations
13,597 Views
27 Pages

fNIRS-EEG BCIs for Motor Rehabilitation: A Review

  • Jianan Chen,
  • Yunjia Xia,
  • Xinkai Zhou,
  • Ernesto Vidal Rosas,
  • Alexander Thomas,
  • Rui Loureiro,
  • Robert J. Cooper,
  • Tom Carlson and
  • Hubin Zhao

Motor impairment has a profound impact on a significant number of individuals, leading to a substantial demand for rehabilitation services. Through brain–computer interfaces (BCIs), people with severe motor disabilities could have improved comm...

  • Article
  • Open Access
46 Citations
12,926 Views
13 Pages

Machine Learning-Based Prediction of Mental Well-Being Using Health Behavior Data from University Students

  • Hanif Abdul Rahman,
  • Madeline Kwicklis,
  • Mohammad Ottom,
  • Areekul Amornsriwatanakul,
  • Khadizah H. Abdul-Mumin,
  • Michael Rosenberg and
  • Ivo D. Dinov

Background: Since the onset of the COVID-19 pandemic in early 2020, the importance of timely and effective assessment of mental well-being has increased dramatically. Machine learning (ML) algorithms and artificial intelligence (AI) techniques can be...

  • Article
  • Open Access
46 Citations
5,377 Views
26 Pages

Enhancing Skin Cancer Detection and Classification in Dermoscopic Images through Concatenated MobileNetV2 and Xception Models

  • Roseline Oluwaseun Ogundokun,
  • Aiman Li,
  • Ronke Seyi Babatunde,
  • Chinecherem Umezuruike,
  • Peter O. Sadiku,
  • AbdulRahman Tosho Abdulahi and
  • Akinbowale Nathaniel Babatunde

One of the most promising research initiatives in the healthcare field is focused on the rising incidence of skin cancer worldwide and improving early discovery methods for the disease. The most significant factor in the fatalities caused by skin can...

  • Article
  • Open Access
46 Citations
11,409 Views
13 Pages

Deep Learning-Based Recognition of Periodontitis and Dental Caries in Dental X-ray Images

  • Ivane Delos Santos Chen,
  • Chieh-Ming Yang,
  • Mei-Juan Chen,
  • Ming-Chin Chen,
  • Ro-Min Weng and
  • Chia-Hung Yeh

Dental X-ray images are important and useful for dentists to diagnose dental diseases. Utilizing deep learning in dental X-ray images can help dentists quickly and accurately identify common dental diseases such as periodontitis and dental caries. Th...

  • Article
  • Open Access
45 Citations
6,135 Views
15 Pages

In recent years, the development of adaptive models to tailor instructional content to learners by measuring their cognitive load has become a topic of active research. Brain fog, also known as confusion, is a common cause of poor performance, and re...

  • Article
  • Open Access
44 Citations
2,881 Views
24 Pages

An Intelligent Approach for Early and Accurate Predication of Cardiac Disease Using Hybrid Artificial Intelligence Techniques

  • Hazrat Bilal,
  • Yibin Tian,
  • Ahmad Ali,
  • Yar Muhammad,
  • Abid Yahya,
  • Basem Abu Izneid and
  • Inam Ullah

This study proposes a new hybrid machine learning (ML) model for the early and accurate diagnosis of heart disease. The proposed model is a combination of two powerful ensemble ML models, namely ExtraTreeClassifier (ETC) and XGBoost (XGB), resulting...

  • Review
  • Open Access
44 Citations
4,736 Views
17 Pages

Towards Transparent Healthcare: Advancing Local Explanation Methods in Explainable Artificial Intelligence

  • Carlo Metta,
  • Andrea Beretta,
  • Roberto Pellungrini,
  • Salvatore Rinzivillo and
  • Fosca Giannotti

This paper focuses on the use of local Explainable Artificial Intelligence (XAI) methods, particularly the Local Rule-Based Explanations (LORE) technique, within healthcare and medical settings. It emphasizes the critical role of interpretability and...

  • Article
  • Open Access
44 Citations
7,381 Views
25 Pages

There is no doubt that brain tumors are one of the leading causes of death in the world. A biopsy is considered the most important procedure in cancer diagnosis, but it comes with drawbacks, including low sensitivity, risks during biopsy treatment, a...

  • Feature Paper
  • Article
  • Open Access
44 Citations
5,603 Views
10 Pages

Effect of Fabrication Technology on the Accuracy of Surgical Guides for Dental-Implant Surgery

  • Lucio Lo Russo,
  • Laura Guida,
  • Pierluigi Mariani,
  • Vincenzo Ronsivalle,
  • Crescenzio Gallo,
  • Marco Cicciù and
  • Luigi Laino

Background: The accuracy of surgical guides is a relevant factor in both surgical safety and prosthetic implications. The impact of widespread fabrication technologies (milling and 3D printing) was investigated. Methods: Surgical guides manufactured...

  • Article
  • Open Access
43 Citations
12,288 Views
30 Pages

Anomaly Detection for Sensor Signals Utilizing Deep Learning Autoencoder-Based Neural Networks

  • Fatemeh Esmaeili,
  • Erica Cassie,
  • Hong Phan T. Nguyen,
  • Natalie O. V. Plank,
  • Charles P. Unsworth and
  • Alan Wang

Anomaly detection is a significant task in sensors’ signal processing since interpreting an abnormal signal can lead to making a high-risk decision in terms of sensors’ applications. Deep learning algorithms are effective tools for anomal...

  • Review
  • Open Access
43 Citations
17,979 Views
33 Pages

Placental-Derived Biomaterials and Their Application to Wound Healing: A Review

  • Nicole M. Protzman,
  • Yong Mao,
  • Desiree Long,
  • Raja Sivalenka,
  • Anna Gosiewska,
  • Robert J. Hariri and
  • Stephen A. Brigido

Chronic wounds are associated with considerable patient morbidity and present a significant economic burden to the healthcare system. Often, chronic wounds are in a state of persistent inflammation and unable to progress to the next phase of wound he...

  • Article
  • Open Access
42 Citations
4,862 Views
17 Pages

GIT-Net: An Ensemble Deep Learning-Based GI Tract Classification of Endoscopic Images

  • Hemalatha Gunasekaran,
  • Krishnamoorthi Ramalakshmi,
  • Deepa Kanmani Swaminathan,
  • Andrew J and
  • Manuel Mazzara

This paper presents an ensemble of pre-trained models for the accurate classification of endoscopic images associated with Gastrointestinal (GI) diseases and illnesses. In this paper, we propose a weighted average ensemble model called GIT-NET to cla...

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354