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Bioengineering, Volume 13, Issue 1

2026 January - 126 articles

Cover Story: This study developed a biomimetic alveolar model using GelMA hydrogel microspheres, combined with an oxygen-permeable honeycomb microwell array. The model enabled A549 cells and primary mouse alveolar epithelial cells to form a curved monolayer structure on microspheres that mimics the native alveolar epithelium. Toxicity tests using H2S-releasing microspheres demonstrated localized cytotoxicity, downregulated SFTPC expression and upregulated apoptosis-related genes. SARS-CoV-2 pseudovirus infection experiments revealed that the 3D model required significantly higher antibody concentrations for neutralization compared to 2D cultures. This biomimetic model provides a robust platform for respiratory toxicity research, pathogen studies and drug screening. View this paper
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Articles (126)

  • Article
  • Open Access
175 Views
28 Pages

Accurate interpretation of missense variants in cancer-associated genes remains a critical challenge in precision oncology, as most sequence-based predictors lack mechanistic explanations. Receptor tyrosine kinases like FGFR2 exemplify this problem:...

  • Article
  • Open Access
201 Views
27 Pages

Objectives: This study presents the development of a bilingual, expert-evaluated question–answer (Q&A) dataset, named PMR-Q&A, designed for training large language models (LLMs) in the field of Physical Medicine and Rehabilitation (PMR)...

  • Article
  • Open Access
196 Views
15 Pages

Collateral status is an important therapeutic indicator for acute ischemic stroke (AIS), yet visual collateral grading remains subjective and suffers from inter-observer variability. To address this limitation, this study automatically extracted bina...

  • Article
  • Open Access
303 Views
18 Pages

Neuromuscular Evaluation in Orthodontic–Surgical Treatment: A Comparison Between Monomaxillary and Bimaxillary Surgery

  • Lucia Giannini,
  • Luisa Gigante,
  • Giada Di Iasio,
  • Giovanni Cattaneo and
  • Cinzia Maspero

Purpose: Orthognathic surgery is a cornerstone therapeutic approach for correcting dentofacial deformities; however, its Impact on neuromuscular adaptation remains incompletely understood, particularly regarding different surgical strategies. The aim...

  • Systematic Review
  • Open Access
205 Views
15 Pages

Performance of Artificial Intelligence Models in Radiographic Image Analysis for Predicting Hip and Knee Prosthesis Failure: A Systematic Review

  • Riccardo Stuani,
  • Marco Di Maio,
  • Vincenzo Di Matteo,
  • Katia Chiappetta,
  • Guido Grappiolo and
  • Mattia Loppini

Background and objectives: The increasing volume of total hip and knee arthroplasty created a significant postoperative surveillance burden. While plain radiographs are standard, the detection of aseptic loosening is subjective. This review evaluates...

  • Systematic Review
  • Open Access
234 Views
16 Pages

Quantifying In Vivo Arterial Deformation from CT and MRI: A Systematic Review of Segmentation, Motion Tracking, and Kinematic Metrics

  • Rodrigo Valente,
  • Bernardo Henriques,
  • André Mourato,
  • José Xavier,
  • Moisés Brito,
  • Stéphane Avril,
  • António Tomás and
  • José Fragata

This article presents a systematic review on methods for quantifying three-dimensional, time-resolved (3D+t) deformation and motion of human arteries from Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Following Preferred Reporting It...

  • Article
  • Open Access
276 Views
19 Pages

Wearable sensors generate continuous physiological and behavioral data at a population scale, yet wellness prediction remains limited by noisy measurements, irregular sampling, and subjective outcomes. We introduce HybridSense, a unified framework th...

  • Article
  • Open Access
233 Views
19 Pages

Atypical Resting-State and Task-Evoked EEG Signatures in Children with Developmental Language Disorder

  • Aimin Liang,
  • Zhijun Cui,
  • Yang Shi,
  • Chunyan Qu,
  • Zhuang Wei,
  • Hanxiao Wang,
  • Xu Zhang,
  • Xiaolin Ning,
  • Xin Ni and
  • Jiancheng Fang

Developmental Language Disorder (DLD) is associated with abnormalities in both intrinsic resting-state brain networks and task-evoked neural responses, yet direct electrophysiological evidence linking these levels remains limited. This study examined...

  • Article
  • Open Access
224 Views
23 Pages

Automated assessment of coronary artery (CA) lesions via Coronary Computed Tomography Angiography (CCTA) is essential for the diagnosis of coronary artery disease (CAD). However, current deep learning approaches confront several challenges, primarily...

  • Systematic Review
  • Open Access
247 Views
29 Pages

Integrating Genomics, Radiomics, and Pathomics in Oncology: A Scoping Review and a Framework for AI-Enabled Surgomics

  • Selma Mtoor,
  • Niki Rashidian,
  • Nouredin Messaoudi,
  • Vincent Grasso,
  • Floriane Noel,
  • Michele Steindler,
  • Derar Jaradat,
  • Isabella Frigerio,
  • Giovanni Butturini and
  • Andrew A. Gumbs
  • + 10 authors

Background: Multimodal AI integration across genomics, radiomics, and pathomics is rapidly evolving in oncology, but evidence remains heterogeneous and unevenly distributed across modalities. Objective: To map empirical studies integrating two or mor...

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Bioengineering - ISSN 2306-5354