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Most Cited

  • Review
  • Open Access
153 Citations
43,051 Views
31 Pages

The purpose of this literature review is to provide a fundamental synopsis of current research pertaining to artificial intelligence (AI) within the domain of clinical practice. Artificial intelligence has revolutionized the field of medicine and hea...

  • Review
  • Open Access
44 Citations
9,609 Views
15 Pages

The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview

  • Sara Ricardo-Rodrigues,
  • Maria Inês Rouxinol,
  • Ana Cristina Agulheiro-Santos,
  • Maria Eduarda Potes,
  • Marta Laranjo and
  • Miguel Elias

6 February 2024

Consumers are looking for safer and more natural food options that are produced through natural methods without using synthetic preservatives. They also desire extended shelf life for their food products. Several medicinal and aromatic plants species...

  • Review
  • Open Access
35 Citations
14,125 Views
17 Pages

24 November 2023

Circular dichroism (CD) spectroscopy has emerged as a powerful tool in the study of protein folding, structure, and function. This review explores the versatile applications of CD spectroscopy in unraveling the intricate relationship between protein...

  • Review
  • Open Access
33 Citations
7,896 Views
26 Pages

Wine Grapes Ripening: A Review on Climate Effect and Analytical Approach to Increase Wine Quality

  • Maria Inês Rouxinol,
  • Maria Rosário Martins,
  • João Mota Barroso and
  • Ana Elisa Rato

Red wine grapes have an important impact on the economy of many regions, both for wine quality and for their richness in phenolic compounds, which have many health benefits. Climate has been changing substantially in the last years, which affects gre...

  • Review
  • Open Access
20 Citations
10,217 Views
32 Pages

A Review of Deep Learning Techniques for Leukemia Cancer Classification Based on Blood Smear Images

  • Rakhmonalieva Farangis Oybek Kizi,
  • Tagne Poupi Theodore Armand and
  • Hee-Cheol Kim

This research reviews deep learning methodologies for detecting leukemia, a critical cancer diagnosis and treatment aspect. Using a systematic mapping study (SMS) and systematic literature review (SLR), thirty articles published between 2019 and 2023...

  • Article
  • Open Access
20 Citations
10,056 Views
14 Pages

4 December 2023

Exploratory data analysis and statistical moments were used to investigate the potential impact of ceiling and floor effects in medical trials. A total of 150 treatment-naive eyes were assessed in a retrospective case study of patients who were treat...

  • Feature Paper
  • Review
  • Open Access
19 Citations
5,363 Views
17 Pages

Crossiella, a Rare Actinomycetota Genus, Abundant in the Environment

  • Tamara Martin-Pozas,
  • Jose Luis Gonzalez-Pimentel,
  • Valme Jurado,
  • Leonila Laiz,
  • Juan Carlos Cañaveras,
  • Angel Fernandez-Cortes,
  • Soledad Cuezva,
  • Sergio Sanchez-Moral and
  • Cesareo Saiz-Jimenez

The genus Crossiella contains two species, C. equi, causing nocardioform placentitis in horses, and C. cryophila, an environmental bacterium. Apart from C. equi, which is not discussed here, environmental Crossiella is rarely reported in the literatu...

  • Article
  • Open Access
17 Citations
8,983 Views
20 Pages

Phytochemical Screening, Polyphenol and Flavonoid Contents, and Antioxidant and Antimicrobial Activities of Opilia amentacea Roxb. (Opiliaceae) Extracts

  • Ollo Youl,
  • Belinda Ramata Hafouo Moné-Bassavé,
  • Sibidou Yougbaré,
  • Boubacar Yaro,
  • Tata Kadiatou Traoré,
  • Rainatou Boly,
  • Josias B. Gérard Yaméogo,
  • Moumouni Koala,
  • Noufou Ouedraogo and
  • Adama Hilou
  • + 3 authors

6 September 2023

Dermatoses are essentially caused by infection or free radical aggression, immunoallergic disorders, or can be secondary to general diseases. Management of dermatoses by modern medicine is complex and costly, and the development of alternative treatm...

  • Article
  • Open Access
16 Citations
4,509 Views
19 Pages

The metabolic diversity of soil microbiota embodies diverse functional capabilities that support ecosystem resilience, driving essential biogeochemical processes and facilitating the optimization of sustainable agricultural systems. Integrating cover...

  • Review
  • Open Access
16 Citations
5,777 Views
21 Pages

A Review of the Important Weapons against Antimicrobial Resistance in Sub-Saharan Africa

  • Noel Gahamanyi,
  • Therese Umuhoza,
  • Shamsaldeen Ibrahim Saeed,
  • Landry Ndriko Mayigane and
  • Jean Nepomuscene Hakizimana

Antimicrobial resistance (AMR) is one of the top 10 global health threats facing humanity, and the sub-Saharan Africa (SSA) is among the heavily affected regions due to its weak health systems and limited resources. Due to an escalating number of AMR...

  • Review
  • Open Access
16 Citations
5,358 Views
21 Pages

Multifunctional materials and devices with captivating properties can be assembled from cellulose and cellulose-based composite materials combining functionality with structural performance. Cellulose is one of the most abundant renewable materials w...

  • Review
  • Open Access
16 Citations
22,591 Views
34 Pages

Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

  • Natália M. de Oliveira,
  • Jorge Machado,
  • Maria Helena Chéu,
  • Lara Lopes and
  • Maria Begoña Criado

22 September 2024

The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate is highly favorable to the synthesis of phenolic compounds, stored in olive leaves; their consumption has been linked to a lower incidence of...

  • Article
  • Open Access
12 Citations
7,725 Views
17 Pages

Green Synthesis and Characterization of Iron Oxide Nanoparticles Using Egeria densa Plant Extract

  • Maruf Olaide Yekeen,
  • Mubarak Ibrahim,
  • James Wachira and
  • Saroj Pramanik

An aqueous leaf extract of Egeria densa was used to green-synthesize iron (II) and iron (III) oxide nanoparticles from ferrous sulphate and ferric chloride, respectively. The successful green synthesis of the nanoparticles was confirmed through UV&nd...

  • Article
  • Open Access
12 Citations
5,900 Views
12 Pages

Fostering Resilience and Wellness: The Synergy of Mindful Eating and the Mediterranean Lifestyle

  • Efstratios Christodoulou,
  • Georgia-Eirini Deligiannidou,
  • Christos Kontogiorgis,
  • Constantinos Giaginis and
  • Antonios E. Koutelidakis

17 January 2024

Increasing evidence indicates that the cultivation of mindful eating, adherence to the Mediterranean lifestyle, and the development of psychological resilience may contribute to the enhancement of overall health and well-being. The purpose of this st...

  • Review
  • Open Access
11 Citations
8,051 Views
21 Pages

25 October 2023

Single Nucleotide Polymorphisms (SNPs) are variations that occur at single nucleotides in the genome and are present at an appreciable level in a population. SNPs can be linked to phenotypes of interest, for example diseases, recent adaptations, or s...

  • Article
  • Open Access
10 Citations
2,797 Views
29 Pages

Computational and Experimental Investigation of the Combined Effect of Various 3D Scaffolds and Bioreactor Stimulation on Human Cells’ Feedback

  • Foteini K. Kozaniti,
  • Aikaterini E. Manara,
  • Vassilis Kostopoulos,
  • Panagiotis Mallis,
  • Efstathios Michalopoulos,
  • Demosthenes Polyzos,
  • Despina D. Deligianni and
  • Diana V. Portan

Computational methods were combined with an experimental setup in order to investigate the response of human umbilical cord stem cells to 3D electrospun and printed scaffolds, when dynamically stimulated in a bioreactor. Key parameters associated to...

  • Feature Paper
  • Review
  • Open Access
10 Citations
7,069 Views
18 Pages

Deregulations of RNA Pol II Subunits in Cancer

  • Martina Muste Sadurni and
  • Marco Saponaro

24 August 2023

Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being a common feature of several cancers. Often, deregulated transcription is a consequence of alterations in transcription factors (TFs),...

  • Review
  • Open Access
9 Citations
4,257 Views
14 Pages

Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles

  • Renata F. Saito,
  • Camila Maria Longo Machado,
  • Ana Luiza Oliveira Lomba,
  • Andréia Hanada Otake and
  • Maria Cristina Rangel

From an evolutive perspective, tumor cells endure successive turnover upon stress conditions and pressure to adapt to new environments. These cells use exceptional communication skills to share biological information to “survive upon every meta...

  • Review
  • Open Access
9 Citations
3,190 Views
26 Pages

Hematologic malignancies, including leukemia, lymphoma, and multiple myeloma, pose significant therapeutic challenges due to their heterogeneity and high relapse rates. Nanotechnology has emerged as a promising avenue for precision drug delivery in t...

  • Article
  • Open Access
8 Citations
3,136 Views
14 Pages

Coupled Biogas and Fiber Production from Agricultural Residues and Energy Crops with Steam Explosion Treatment

  • Benedikt Hülsemann,
  • Marian Baumgart,
  • Leonhard Lenz,
  • Elviliana,
  • Marie Föllmer,
  • Gregor Sailer,
  • Konstantin Dinkler and
  • Hans Oechsner

The global demand for packaging materials and energy is constantly increasing, requiring the exploration of new concepts. In this work, we presented a bioeconomic concept that uses steam explosion and phase separation to simultaneously generate fiber...

  • Review
  • Open Access
8 Citations
5,853 Views
27 Pages

Lactiplantibacillus plantarum is omnipresent in vegetable fermentations. Its large metabolic capacity and its ability to adapt to the fermenting microenvironment enable this species, in many cases, to dominate the microecosystem and drive the ferment...

  • Review
  • Open Access
8 Citations
4,129 Views
16 Pages

Over the last ten years, with the progress of in vitro culture methods, it has been possible to build increasingly reliable models to effectively mimic in vivo ones. The translational methodological approach that combined biotechnology and biomedical...

  • Review
  • Open Access
8 Citations
3,719 Views
22 Pages

Nanobiotechnology in Bone Tissue Engineering Applications: Recent Advances and Future Perspectives

  • Neelam Iqbal,
  • Tejal Pant,
  • Nanda Rohra,
  • Abhishek Goyal,
  • Merin Lawrence,
  • Anomitra Dey and
  • Payal Ganguly

15 November 2023

Bone regeneration and repair are complex processes with the potential of added complications, like delayed repair, fracture non-union, and post-surgical infections. These conditions remain a challenge globally, pressurizing the economy and patients s...

  • Article
  • Open Access
8 Citations
2,600 Views
21 Pages

1 November 2023

In apple (Malus domestica), the level and timing of crop load have a major impact on the final fruit size and can also play a role in optimising internal fruit quality. Ideal crop loads vary with cultivar, but very few cultivars have recommended crop...

  • Review
  • Open Access
6 Citations
4,888 Views
34 Pages

Can Caenorhabditis elegans Serve as a Reliable Model for Drug and Nutraceutical Discovery?

  • Opeyemi. O. Deji-Oloruntoba,
  • Taiwo. O. Elufioye,
  • Stephen Adeniyi Adefegha and
  • Miran Jang

Experimental research demands the selection of appropriate models to align with study objectives and conditions. Traditional experimental models, such as in vivo animal studies and in vitro systems like organoids, present nutraceutical and pharmaceut...

  • Article
  • Open Access
6 Citations
4,192 Views
16 Pages

1 September 2023

The interest in under-utilized crops as a functional food for animals and humans has been increasing recently with advancing research and the need for crop improvement. Canadian forage crops including alfalfa (Medicago sativa L.) and fenugreek (Trigo...

  • Article
  • Open Access
6 Citations
2,048 Views
13 Pages

Phytochemical Profile, Antioxidant and Antimicrobial Activity of Two Species of Oak: Quercus sartorii and Quercus rysophylla

  • Elizabeth Coyotl-Martinez,
  • Juan Alex Hernández-Rivera,
  • José L. Arturo Parra-Suarez,
  • Sandra Raquel Reyes-Carmona and
  • Alan Carrasco-Carballo

The genus Quercus (Fagaceae) is one of the most widely distributed and species-diverse trees in the Northern Hemisphere. The present study addresses the investigation of the phyto-chemical profile by ten assays, the antioxidant activity scavenging of...

  • Review
  • Open Access
6 Citations
4,903 Views
20 Pages

Sustainable Pulse Proteins: Physical, Chemical and Fermentative Modifications

  • Seedhabadee Ganeshan,
  • Nancy Asen,
  • Yingxin Wang,
  • Mehmet Ç. Tülbek and
  • Michael T. Nickerson

Pulse proteins are playing significant roles in the alternative protein space due to the demand for foods produced in an environmentally sustainable manner and, most importantly, due to the demand for foods of nutritious value. There has been extensi...

  • Article
  • Open Access
6 Citations
3,400 Views
12 Pages

GC×GC-TOFMS Analysis of Fecal Metabolome Stabilized Using an At-Home Stool Collection Device

  • Ryland T. Giebelhaus,
  • Gwen Nguyen,
  • Sheri A. Schmidt,
  • Seoin Wang,
  • Ewenet Y. Mesfin,
  • Seo Lin Nam,
  • A. Paulina de la Mata and
  • James J. Harynuk

14 August 2024

Stool is a mixture of excrement, microbiota, enzymes, undigested material, and small molecules. Fecal metabolomics has gained interest recently, owing to advances in metabolomics and growing research into both the host’s physiology and the gut...

  • Article
  • Open Access
6 Citations
2,818 Views
16 Pages

Refractance Window Drying as an Alternative Method for Brewer’s Spent Grain Preservation

  • Neiton C. Silva,
  • Andressa O. Santos,
  • Claudio R. Duarte and
  • Marcos A. S. Barrozo

1 February 2024

Brewer’s spent grain (BSG) is a residue that holds significant potential for various applications. Given its inherently high moisture levels, it becomes imperative to explore methods for preserving it. This study investigates the use of refract...

  • Article
  • Open Access
5 Citations
5,552 Views
22 Pages

17 August 2023

Rapid and accurate pathogen identification is crucial in effectively combating infectious diseases. However, the current diagnostic tools for bacterial infections predominantly rely on century-old culture-based methods. Furthermore, recent research h...

  • Article
  • Open Access
5 Citations
2,992 Views
15 Pages

Effect of Doxapram, a K2p Channel Blocker, and pH on Heart Rate: Larval Drosophila Model

  • Elizabeth R. Elliott,
  • Alaina C. Taul,
  • Maya O. Abul-Khoudoud,
  • Nicole Hensley and
  • Robin L. Cooper

3 August 2023

Two-P-domain K+ (K2p) channels are responsible for maintaining the resting membrane potential. K2p channels have varied expression in healthy tissue, but they also change in cancerous or diseased states. The correlation and causation as regards the a...

  • Review
  • Open Access
5 Citations
14,671 Views
14 Pages

Distraction Osteogenesis: A Comprehensive Review

  • Babapelumi Adejuyigbe,
  • Mohini Gharpure,
  • Charlotte F. Wahle and
  • Jennifer R. Kallini

21 November 2024

Distraction osteogenesis (DO) is a process which uses the bone’s natural healing tendencies to repair and lengthen pathologic, missing, or malformed bone. The mechanism of DO mimics the pathway that the body uses in any other fracture repair ho...

  • Article
  • Open Access
5 Citations
4,257 Views
15 Pages

Digital Pathology and Ensemble Deep Learning for Kidney Cancer Diagnosis: Dartmouth Kidney Cancer Histology Dataset

  • Muskan Naresh Jain,
  • Salah Mohammed Awad Al-Heejawi,
  • Jamil R. Azzi and
  • Saeed Amal

Kidney cancer has become a major global health issue over time, showing how early detection can play a very important role in mediating the disease. Traditional histological image analysis is recognized as the clinical gold standard for diagnosis, al...

  • Review
  • Open Access
5 Citations
4,846 Views
16 Pages

29 April 2024

Growing demands for sustainable and ecological nanoparticle synthesis methods have incentivized the scientific community to develop new approaches to counteract these challenges. Green synthesis resorts to biocomponents obtained from plants, bacteria...

  • Article
  • Open Access
5 Citations
3,742 Views
13 Pages

Chitinases are biotechnologically relevant enzymes that can be applied in such different sectors as pharmaceutical, food, environmental management, the biocontrol of pests and in the paper and cellulose industry. Microorganisms as filamentous fungi a...

  • Article
  • Open Access
5 Citations
1,860 Views
22 Pages

The build-up of lipofuscin—an age-associated biomarker referred to as hyperfluorescence—is considered a precursor in the progression of geographic atrophy (GA). Prior studies have attempted to classify hyperfluorescent regions to explain...

  • Article
  • Open Access
4 Citations
2,629 Views
14 Pages

Biostimulant Effect of Commercial Rhizobacteria Formulation on the Growth of Vitis vinifera L.: Case of Optimal and Water Deficit Conditions

  • Vasileios Papantzikos,
  • Areti Papanikou,
  • Vasileios Stournaras,
  • Paraskevi Mpeza,
  • Spiridon Mantzoukas and
  • Georgios Patakioutas

As climate change is an imminent threat to the environment and agriculture, there is an increasing need to find immediate solutions capable of compensating for water deficits even in semi-arid conditions. This study is focused on the evaluation of th...

  • Article
  • Open Access
4 Citations
2,940 Views
11 Pages

Caffeic Acid and Biopesticides Interactions for the Control of Storage Beetles

  • Chrysanthi Zarmakoupi,
  • Konstantinos Mpistiolis,
  • George Pantazis,
  • Panagiota Psatha,
  • Despoina Dimitriadi,
  • Foteini Kitsiou,
  • Panagiotis Eliopoulos,
  • George Patakioutas and
  • Spiridon Mantzoukas

Infestations of stored-product pests cause significant losses of agricultural produce every year. Despite various environmental and health risks, chemical insecticides are now a ready-to-use solution for pest control. Against this background and in t...

  • Article
  • Open Access
4 Citations
3,219 Views
11 Pages

Exploring the Anxiolytic, Antidepressant, and Immunomodulatory Effects of Cannabidiol in Acute Stress Rat Models

  • Hristina Zlatanova-Tenisheva,
  • Maria Georgieva-Kotetarova,
  • Natalia Vilmosh,
  • Ilin Kandilarov,
  • Delyan Delev,
  • Tihomir Dermendzhiev and
  • Ilia Dimitrov Kostadinov

Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis sativa, is believed to have anxiety-reducing and antidepressant effects. However, existing data are inconsistent, likely due to variations in experimental designs, dosages, and stre...

  • Article
  • Open Access
4 Citations
5,135 Views
21 Pages

Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus

  • Andrew Nelson,
  • Steven Voinier,
  • Jeremy Tran,
  • Kristin H. Gilchrist,
  • Melvin Helgeson,
  • Vincent B. Ho and
  • George J. Klarmann

6 February 2024

Torn and damaged menisci resulting from trauma are very common knee injuries, which can cause pain and mobility limitations and lead to osteoarthritis. Meniscal injuries can require surgery to repair the tissue damage and restore mobility. Here we de...

  • Article
  • Open Access
4 Citations
2,398 Views
14 Pages

Growth Performance, Meat Quality, and Lipid Oxidation in Pigs’ Fed Diets Containing Grape Pomace

  • Barbara Cristina da Silveira Almeida,
  • Maria do Carmo Mohaupt Marques Ludke,
  • Teresinha Marisa Bertol,
  • Jorge Vitor Ludke,
  • Daniela Miotto Bernardi,
  • Anildo Cunha Jr. and
  • Arlei Coldebella

31 August 2024

Grape pomace is a winery byproduct that is rich in polyphenols with antioxidant capacity. This study investigated the effect of 0, 5, and 10% inclusion of dehydrated grape pomace (DGP) in finishing pig diets on the growth performance, carcass traits,...

  • Review
  • Open Access
4 Citations
3,669 Views
14 Pages

As isobutanol exhibits higher energy density and lower hygroscopicity than ethanol, it is considered a better candidate biofuel. The sustainable supply of inedible biomass and lack of competition with the food supply have stimulated significant world...

  • Article
  • Open Access
4 Citations
3,391 Views
15 Pages

Diatoms as an Indicator of Water Quality in the Kuils River, Western Cape, South Africa

  • Leona Kuturo,
  • Ntokozo Malaza,
  • Arnelia Natalie Paulse and
  • Philani Mpungose

6 December 2024

Rivers are crucial hydrological cycle components, supporting ecosystems and human activities. Managing and protecting river water quality is essential. Diatoms, microscopic algae, are widespread and sensitive to changes in water quality, making them...

  • Review
  • Open Access
3 Citations
4,209 Views
13 Pages

Urinary Markers for Prostate Cancer: State of the Art

  • Carlo Giorgio Costi,
  • Serena Sartori,
  • Riccardo Danuso,
  • Andrea Piasentin,
  • Paolo Umari and
  • Giovanni Liguori

Prostate cancer (PCa) is one of the most common malignancies in men, where early and accurate detection is crucial. While PSA testing has been the diagnostic standard, its limited specificity leads to unnecessary biopsies and missed significant cance...

  • Review
  • Open Access
3 Citations
3,284 Views
20 Pages

Bacterial Sialidases: Biological Significance and Application

  • Stephan Engibarov,
  • Yana Gocheva,
  • Irina Lazarkevich and
  • Rumyana Eneva

This review summarizes recent findings on the diverse roles of bacterial sialidases in microbial biology. Bacterial sialidases, also known as neuraminidases, are exog α-lycosidases that cleave terminal sialic acid residues from a number of comp...

  • Article
  • Open Access
3 Citations
3,217 Views
16 Pages

An Event-Driven Architecture for Genomics-Based Diagnostic Data Processing

  • Thomas Krause,
  • Mike Zickfeld,
  • Sebastian Bruchhaus,
  • Thoralf Reis,
  • Marco X. Bornschlegl,
  • Paolo Buono,
  • Michael Kramer,
  • Paul Mc Kevitt and
  • Matthias Hemmje

Genomics-based diagnostic data (GBDD) are becoming increasingly important for laboratory diagnostics. Due to the large quantity of data and their heterogeneity, GBDD poses a big data challenge. Current analysis tools for GBDD are primarily designed f...

  • Review
  • Open Access
3 Citations
3,874 Views
17 Pages

Tuning Up In Vitro Growth and Development of Cannabis sativa: Recent Advances in Micropropagational Approach

  • S. M. Ahsan,
  • Md. Injamum-Ul-Hoque,
  • Ashim Kumar Das,
  • Shifa Shaffique,
  • Mehedi Hasan,
  • Sang-Mo Kang,
  • In-Jung Lee and
  • Hyong Woo Choi

Cannabis sativa is used for multiple purposes, notably for its medicinal properties. It produces various secondary metabolites, including cannabinoids, terpenes, and flavonoids, which have therapeutic value and typically produce high amounts in femal...

  • Article
  • Open Access
3 Citations
3,800 Views
21 Pages

Central nervous system (CNS) white matter pathologies accompany many diseases across the lifespan, yet their biochemical bases, mechanisms, and consequences have remained poorly understood due to the complexity of myelin lipid-based research. However...

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Appl. Biosci. - ISSN 2813-0464