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Most Cited

  • Review
  • Open Access
79 Citations
15,376 Views
22 Pages

Digital twins (DTs) are becoming increasingly popular in various industries, and their potential for healthcare in the metaverse continues to attract attention. The metaverse is a virtual world where individuals interact with digital replicas of them...

  • Review
  • Open Access
75 Citations
20,105 Views
49 Pages

Deep learning has emerged as a powerful tool for medical image analysis and diagnosis, demonstrating high performance on tasks such as cancer detection. This literature review synthesizes current research on deep learning techniques applied to lung c...

  • Review
  • Open Access
70 Citations
20,166 Views
33 Pages

Genomics for Emerging Pathogen Identification and Monitoring: Prospects and Obstacles

  • Vishakha Vashisht,
  • Ashutosh Vashisht,
  • Ashis K. Mondal,
  • Jaspreet Farmaha,
  • Ahmet Alptekin,
  • Harmanpreet Singh,
  • Pankaj Ahluwalia,
  • Anaka Srinivas and
  • Ravindra Kolhe

Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemic highlight...

  • Review
  • Open Access
58 Citations
23,875 Views
47 Pages

Recent Advances in Large Language Models for Healthcare

  • Khalid Nassiri and
  • Moulay A. Akhloufi

Recent advances in the field of large language models (LLMs) underline their high potential for applications in a variety of sectors. Their use in healthcare, in particular, holds out promising prospects for improving medical practices. As we highlig...

  • Review
  • Open Access
55 Citations
10,798 Views
16 Pages

This review explores the transformative integration of artificial intelligence (AI) and healthcare through conversational AI leveraging Natural Language Processing (NLP). Focusing on Large Language Models (LLMs), this paper navigates through various...

  • Article
  • Open Access
48 Citations
7,708 Views
21 Pages

Enhancing Brain Tumor Classification with Transfer Learning across Multiple Classes: An In-Depth Analysis

  • Syed Ahmmed,
  • Prajoy Podder,
  • M. Rubaiyat Hossain Mondal,
  • S M Atikur Rahman,
  • Somasundar Kannan,
  • Md Junayed Hasan,
  • Ali Rohan and
  • Alexander E. Prosvirin

This study focuses on leveraging data-driven techniques to diagnose brain tumors through magnetic resonance imaging (MRI) images. Utilizing the rule of deep learning (DL), we introduce and fine-tune two robust frameworks, ResNet 50 and Inception V3,...

  • Article
  • Open Access
35 Citations
9,342 Views
26 Pages

Supporting the Demand on Mental Health Services with AI-Based Conversational Large Language Models (LLMs)

  • Tin Lai,
  • Yukun Shi,
  • Zicong Du,
  • Jiajie Wu,
  • Ken Fu,
  • Yichao Dou and
  • Ziqi Wang

The demand for psychological counselling has grown significantly in recent years, particularly with the global outbreak of COVID-19, which heightened the need for timely and professional mental health support. Online psychological counselling emerged...

  • Communication
  • Open Access
31 Citations
9,309 Views
21 Pages

The Crucial Role of Interdisciplinary Conferences in Advancing Explainable AI in Healthcare

  • Ankush U. Patel,
  • Qiangqiang Gu,
  • Ronda Esper,
  • Danielle Maeser and
  • Nicole Maeser

As artificial intelligence (AI) integrates within the intersecting domains of healthcare and computational biology, developing interpretable models tailored to medical contexts is met with significant challenges. Explainable AI (XAI) is vital for fos...

  • Article
  • Open Access
31 Citations
4,461 Views
15 Pages

Myocardial Infarction (MI) is the death of the heart muscle caused by lack of oxygenated blood flow to the heart muscle. It has been the main cause of death worldwide. The fastest way to detect MI is by using an electrocardiogram (ECG) device, which...

  • Review
  • Open Access
31 Citations
10,072 Views
14 Pages

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand–supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art computer...

  • Article
  • Open Access
31 Citations
3,649 Views
13 Pages

Identifying Potent Fat Mass and Obesity-Associated Protein Inhibitors Using Deep Learning-Based Hybrid Procedures

  • Kannan Mayuri,
  • Durairaj Varalakshmi,
  • Mayakrishnan Tharaheswari,
  • Chaitanya Sree Somala,
  • Selvaraj Sathya Priya,
  • Nagaraj Bharathkumar,
  • Renganathan Senthil,
  • Raja Babu Singh Kushwah,
  • Sundaram Vickram and
  • Konda Mani Saravanan
  • + 1 author

The fat mass and obesity-associated (FTO) protein catalyzes metal-dependent modifications of nucleic acids, namely the demethylation of methyl adenosine inside mRNA molecules. The FTO protein has been identified as a potential target for developing a...

  • Article
  • Open Access
30 Citations
5,974 Views
26 Pages

Advancing Early Leukemia Diagnostics: A Comprehensive Study Incorporating Image Processing and Transfer Learning

  • Rezaul Haque,
  • Abdullah Al Sakib,
  • Md Forhad Hossain,
  • Fahadul Islam,
  • Ferdaus Ibne Aziz,
  • Md Redwan Ahmed,
  • Somasundar Kannan,
  • Ali Rohan and
  • Md Junayed Hasan

Disease recognition has been revolutionized by autonomous systems in the rapidly developing field of medical technology. A crucial aspect of diagnosis involves the visual assessment and enumeration of white blood cells in microscopic peripheral blood...

  • Article
  • Open Access
29 Citations
7,615 Views
14 Pages

A common consequence of diabetes mellitus called diabetic retinopathy (DR) results in lesions on the retina that impair vision. It can cause blindness if not detected in time. Unfortunately, DR cannot be reversed, and treatment simply keeps eyesight...

  • Article
  • Open Access
28 Citations
7,819 Views
19 Pages

The reduction of childhood mortality is an ongoing struggle and a commonly used factor in determining progress in the medical field. The under-5 mortality number is around 5 million around the world, with many of the deaths being preventable. In ligh...

  • Review
  • Open Access
28 Citations
7,652 Views
16 Pages

This article delves into the intersection of generative AI and digital twins within drug discovery, exploring their synergistic potential to revolutionize pharmaceutical research and development. Through various instances and examples, we illuminate...

  • Article
  • Open Access
21 Citations
9,909 Views
16 Pages

Breast cancer is among the most common cancers found in women, causing cancer-related deaths and making it a severe public health issue. Early prediction of breast cancer can increase the chances of survival and promote early medical treatment. Moreo...

  • Article
  • Open Access
20 Citations
11,096 Views
12 Pages

Background: Currently, discriminating Iron Deficiency Anemia (IDA) from other anemia requires an expensive test (serum ferritin). Complete Blood Count (CBC) tests are less costly and more widely available. Machine learning models have not yet been ap...

  • Article
  • Open Access
19 Citations
7,809 Views
15 Pages

Real-Time Jaundice Detection in Neonates Based on Machine Learning Models

  • Ahmad Yaseen Abdulrazzak,
  • Saleem Latif Mohammed,
  • Ali Al-Naji and
  • Javaan Chahl

Introduction: Despite the many attempts made by researchers to diagnose jaundice non-invasively using machine learning techniques, the low amount of data used to build their models remains the key factor limiting the performance of their models. Obje...

  • Review
  • Open Access
18 Citations
14,961 Views
64 Pages

Lung cancer is a leading cause of cancer-related deaths worldwide, emphasizing the significance of early detection. Computer-aided diagnostic systems have emerged as valuable tools for aiding radiologists in the analysis of medical images, particular...

  • Review
  • Open Access
18 Citations
7,441 Views
12 Pages

Exploring the Role of ChatGPT in Oncology: Providing Information and Support for Cancer Patients

  • Maurizio Cè,
  • Vittoria Chiarpenello,
  • Alessandra Bubba,
  • Paolo Florent Felisaz,
  • Giancarlo Oliva,
  • Giovanni Irmici and
  • Michaela Cellina

Introduction: Oncological patients face numerous challenges throughout their cancer journey while navigating complex medical information. The advent of AI-based conversational models like ChatGPT (San Francisco, OpenAI) represents an innovation in on...

  • Article
  • Open Access
18 Citations
5,283 Views
18 Pages

Towards Effective Emotion Detection: A Comprehensive Machine Learning Approach on EEG Signals

  • Ietezaz Ul Hassan,
  • Raja Hashim Ali,
  • Zain ul Abideen,
  • Ali Zeeshan Ijaz and
  • Talha Ali Khan

Emotion detection assumes a pivotal role in the evaluation of adverse psychological attributes, such as stress, anxiety, and depression. This study undertakes an exploration into the prospective capacities of machine learning to prognosticate individ...

  • Article
  • Open Access
17 Citations
4,489 Views
23 Pages

Naturalize Revolution: Unprecedented AI-Driven Precision in Skin Cancer Classification Using Deep Learning

  • Mohamad Abou Ali,
  • Fadi Dornaika,
  • Ignacio Arganda-Carreras,
  • Hussein Ali and
  • Malak Karaouni

Background: In response to the escalating global concerns surrounding skin cancer, this study aims to address the imperative for precise and efficient diagnostic methodologies. Focusing on the intricate task of eight-class skin cancer classification,...

  • Article
  • Open Access
17 Citations
8,371 Views
25 Pages

Survey of Multimodal Medical Question Answering

  • Hilmi Demirhan and
  • Wlodek Zadrozny

Multimodal medical question answering (MMQA) is a vital area bridging healthcare and Artificial Intelligence (AI). This survey methodically examines the MMQA research published in recent years. We collect academic literature through Google Scholar, a...

  • Review
  • Open Access
16 Citations
8,734 Views
26 Pages

Artificial Intelligence (AI) and deep learning models have revolutionized diagnosis, prognostication, and treatment planning by extracting complex patterns from medical images, enabling more accurate, personalized, and timely clinical decisions. Desp...

  • Review
  • Open Access
16 Citations
13,493 Views
17 Pages

Artificial Intelligence in Wound Care: A Narrative Review of the Currently Available Mobile Apps for Automatic Ulcer Segmentation

  • Davide Griffa,
  • Alessio Natale,
  • Yuri Merli,
  • Michela Starace,
  • Nico Curti,
  • Martina Mussi,
  • Gastone Castellani,
  • Davide Melandri,
  • Bianca Maria Piraccini and
  • Corrado Zengarini

Introduction: Chronic ulcers significantly burden healthcare systems, requiring precise measurement and assessment for effective treatment. Traditional methods, such as manual segmentation, are time-consuming and error-prone. This review evaluates th...

  • Article
  • Open Access
16 Citations
7,389 Views
13 Pages

Lip-Reading Advancements: A 3D Convolutional Neural Network/Long Short-Term Memory Fusion for Precise Word Recognition

  • Themis Exarchos,
  • Georgios N. Dimitrakopoulos,
  • Aristidis G. Vrahatis,
  • Georgios Chrysovitsiotis,
  • Zoi Zachou and
  • Efthymios Kyrodimos

Lip reading, the art of deciphering spoken words from the visual cues of lip movements, has garnered significant interest for its potential applications in diverse fields, including assistive technologies, human–computer interaction, and securi...

  • Article
  • Open Access
15 Citations
4,749 Views
23 Pages

Early detection of dyslexia and learning disorders is vital for avoiding a learning disability, as well as supporting dyslexic students by tailoring academic programs to their needs. Several studies have investigated using supervised algorithms to sc...

  • Article
  • Open Access
14 Citations
6,103 Views
36 Pages

Early Breast Cancer Detection Based on Deep Learning: An Ensemble Approach Applied to Mammograms

  • Youness Khourdifi,
  • Alae El Alami,
  • Mounia Zaydi,
  • Yassine Maleh and
  • Omar Er-Remyly

Background: Breast cancer is one of the leading causes of death in women, making early detection through mammography crucial for improving survival rates. However, human interpretation of mammograms is often prone to diagnostic errors. This study add...

  • Review
  • Open Access
14 Citations
8,227 Views
17 Pages

This review explores the integration of artificial intelligence (AI) and machine learning (ML) into kidney transplantation (KT), set against the backdrop of a significant donor organ shortage and the evolution of ‘Next-Generation Healthcare&rsq...

  • Review
  • Open Access
14 Citations
5,607 Views
28 Pages

Automated Methods for Tuberculosis Detection/Diagnosis: A Literature Review

  • Marios Zachariou,
  • Ognjen Arandjelović and
  • Derek James Sloan

Tuberculosis (TB) is one of the leading infectious causes of death worldwide. The effective management and public health control of this disease depends on early detection and careful treatment monitoring. For many years, the microscopy-based analysi...

  • Systematic Review
  • Open Access
14 Citations
24,849 Views
14 Pages

Networks in Healthcare: A Systematic Review

  • Santhosh Kumar Rajamani and
  • Radha Srinivasan Iyer

Networks form the backbone of any healthcare system. Various databases were searched with relevant keywords, data were abstracted, and numerous papers were appraised for this synthesis. This compiled systematic review gives a comprehensive overview o...

  • Review
  • Open Access
14 Citations
4,544 Views
19 Pages

In pharmaceutical research and development, pursuing novel therapeutics and optimizing existing drugs have been revolutionized by the fusion of cutting-edge technologies and computational methodologies. Over the past few decades, the field of drug de...

  • Article
  • Open Access
14 Citations
6,396 Views
17 Pages

Assessment of Voice Disorders Using Machine Learning and Vocal Analysis of Voice Samples Recorded through Smartphones

  • Michele Giuseppe Di Cesare,
  • David Perpetuini,
  • Daniela Cardone and
  • Arcangelo Merla

Background: The integration of edge computing into smart healthcare systems requires the development of computationally efficient models and methodologies for monitoring and detecting patients’ healthcare statuses. In this context, mobile devic...

  • Perspective
  • Open Access
13 Citations
8,203 Views
13 Pages

AlphaFold2 Update and Perspectives

  • Sébastien Tourlet,
  • Ragousandirane Radjasandirane,
  • Julien Diharce and
  • Alexandre G. de Brevern

Access to the three-dimensional (3D) structural information of macromolecules is of major interest in both fundamental and applied research. Obtaining this experimental data can be complex, time consuming, and costly. Therefore, in silico computation...

  • Review
  • Open Access
13 Citations
23,640 Views
40 Pages

Generative Artificial Intelligence in Healthcare: Applications, Implementation Challenges, and Future Directions

  • Syed Arman Rabbani,
  • Mohamed El-Tanani,
  • Shrestha Sharma,
  • Syed Salman Rabbani,
  • Yahia El-Tanani,
  • Rakesh Kumar and
  • Manita Saini

Generative artificial intelligence (AI) is rapidly transforming healthcare systems since the advent of OpenAI in 2022. It encompasses a class of machine learning techniques designed to create new content and is classified into large language models (...

  • Article
  • Open Access
13 Citations
4,241 Views
24 Pages

Background: Creating models to differentiate self-reported mental workload perceptions is challenging and requires machine learning to identify features from EEG signals. EEG band ratios quantify human activity, but limited research on mental workloa...

  • Review
  • Open Access
13 Citations
8,964 Views
26 Pages

Background: Over the past few years, clinical studies have utilized machine learning in telehealth and smart care for disease management, self-management, and managing health issues like pulmonary diseases, heart failure, diabetes screening, and intr...

  • Article
  • Open Access
13 Citations
4,093 Views
12 Pages

Transfer-Learning Approach for Enhanced Brain Tumor Classification in MRI Imaging

  • Amarnath Amarnath,
  • Ali Al Bataineh and
  • Jeremy A. Hansen

Background: Intracranial neoplasm, often referred to as a brain tumor, is an abnormal growth or mass of tissues in the brain. The complexity of the brain and the associated diagnostic delays cause significant stress for patients. This study aims to e...

  • Review
  • Open Access
13 Citations
3,013 Views
23 Pages

Deep Learning and Federated Learning for Screening COVID-19: A Review

  • M. Rubaiyat Hossain Mondal,
  • Subrato Bharati,
  • Prajoy Podder and
  • Joarder Kamruzzaman

Since December 2019, a novel coronavirus disease (COVID-19) has infected millions of individuals. This paper conducts a thorough study of the use of deep learning (DL) and federated learning (FL) approaches to COVID-19 screening. To begin, an evaluat...

  • Editorial
  • Open Access
13 Citations
6,376 Views
9 Pages

Biomedical informatics can be considered as a multidisciplinary research and educational field situated at the intersection of computational sciences (including computer science, data science, mathematics, and statistics), biology, and medicine. In r...

  • Article
  • Open Access
11 Citations
4,498 Views
17 Pages

Utilizing Immunoinformatics for mRNA Vaccine Design against Influenza D Virus

  • Elijah Kolawole Oladipo,
  • Stephen Feranmi Adeyemo,
  • Modinat Wuraola Akinboade,
  • Temitope Michael Akinleye,
  • Kehinde Favour Siyanbola,
  • Precious Ayomide Adeogun,
  • Victor Michael Ogunfidodo,
  • Christiana Adewumi Adekunle,
  • Olubunmi Ayobami Elutade and
  • Helen Onyeaka
  • + 4 authors

Background: Influenza D Virus (IDV) presents a possible threat to animal and human health, necessitating the development of effective vaccines. Although no human illness linked to IDV has been reported, the possibility of human susceptibility to infe...

  • Review
  • Open Access
11 Citations
4,658 Views
16 Pages

Should AI-Powered Whole-Genome Sequencing Be Used Routinely for Personalized Decision Support in Surgical Oncology—A Scoping Review

  • Kokiladevi Alagarswamy,
  • Wenjie Shi,
  • Aishwarya Boini,
  • Nouredin Messaoudi,
  • Vincent Grasso,
  • Thomas Cattabiani,
  • Bruce Turner,
  • Roland Croner,
  • Ulf D. Kahlert and
  • Andrew Gumbs

In this scoping review, we delve into the transformative potential of artificial intelligence (AI) in addressing challenges inherent in whole-genome sequencing (WGS) analysis, with a specific focus on its implications in oncology. Unveiling the limit...

  • Article
  • Open Access
11 Citations
1,925 Views
20 Pages

Background: Malignant breast cancer is the most common cancer affecting women worldwide. The COVID-19 pandemic appears to have slowed the diagnostic process, leading to an enhanced use of invasive approaches such as mastectomy. The increased use of a...

  • Review
  • Open Access
11 Citations
5,884 Views
19 Pages

An Overview of Approaches and Methods for the Cognitive Workload Estimation in Human–Machine Interaction Scenarios through Wearables Sensors

  • Sabrina Iarlori,
  • David Perpetuini,
  • Michele Tritto,
  • Daniela Cardone,
  • Alessandro Tiberio,
  • Manish Chinthakindi,
  • Chiara Filippini,
  • Luca Cavanini,
  • Alessandro Freddi and
  • Andrea Monteriù
  • + 2 authors

Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological...

  • Article
  • Open Access
10 Citations
5,143 Views
28 Pages

Background: Transforming one-dimensional (1D) biomedical signals into two-dimensional (2D) images enables the application of convolutional neural networks (CNNs) for classification tasks. In this study, we investigated the effectiveness of different...

  • Review
  • Open Access
10 Citations
5,593 Views
21 Pages

Cell-free protein synthesis (CFPS) has emerged as a powerful tool for protein production, with applications ranging from basic research to biotechnology and pharmaceutical development. However, enhancing the efficiency of CFPS systems remains a cruci...

  • Article
  • Open Access
10 Citations
3,265 Views
10 Pages

Hearables: In-Ear Multimodal Data Fusion for Robust Heart Rate Estimation

  • Marek Żyliński,
  • Amir Nassibi,
  • Edoardo Occhipinti,
  • Adil Malik,
  • Matteo Bermond,
  • Harry J. Davies and
  • Danilo P. Mandic

Background: Ambulatory heart rate (HR) monitors that acquire electrocardiogram (ECG) or/and photoplethysmographm (PPG) signals from the torso, wrists, or ears are notably less accurate in tasks associated with high levels of movement compared to clin...

  • Article
  • Open Access
10 Citations
8,179 Views
26 Pages

Synthetic MRI Generation from CT Scans for Stroke Patients

  • Jake McNaughton,
  • Samantha Holdsworth,
  • Benjamin Chong,
  • Justin Fernandez,
  • Vickie Shim and
  • Alan Wang

CT scans are currently the most common imaging modality used for suspected stroke patients due to their short acquisition time and wide availability. However, MRI offers superior tissue contrast and image quality. In this study, eight deep learning m...

  • Article
  • Open Access
10 Citations
4,495 Views
17 Pages

Generation of Musculoskeletal Ultrasound Images with Diffusion Models

  • Sofoklis Katakis,
  • Nikolaos Barotsis,
  • Alexandros Kakotaritis,
  • Panagiotis Tsiganos,
  • George Economou,
  • Elias Panagiotopoulos and
  • George Panayiotakis

The recent advances in deep learning have revolutionised computer-aided diagnosis in medical imaging. However, deep learning approaches to unveil their full potential require significant amounts of data, which can be a challenging task in some scient...

  • Article
  • Open Access
10 Citations
4,444 Views
23 Pages

Machine Learning Approach to Identify Case-Control Studies on ApoE Gene Mutations Linked to Alzheimer’s Disease in Italy

  • Giorgia Francesca Saraceno,
  • Diana Marisol Abrego-Guandique,
  • Roberto Cannataro,
  • Maria Cristina Caroleo and
  • Erika Cione

Background: An application of artificial intelligence is machine learning, which allows computer programs to learn and create data. Methods: In this work, we aimed to evaluate the performance of the MySLR machine learning platform, which implements t...

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BioMedInformatics - ISSN 2673-7426