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Toxics, Volume 8, Issue 2

2020 June - 25 articles

Cover Story: Pesticides can promote AD pathology in multiple ways: inhibition of ETC components and activation of NOXs to elevate ROS; activation of GSK-3β to promote BACE1 expression and tau phosphorylation; affecting Aβ fibril formation; inhibition of Wnt signalling; promoting somatic mutation and affecting AD-related genes epigenetically; inhibiting adult neurogenesis; promoting gut microbiota dysbiosis. View this paper
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Articles (25)

  • Communication
  • Open Access
15 Citations
5,595 Views
18 Pages

Combining Different In Vitro Bioassays to Evaluate Genotoxicity of Water-Accommodated Fractions from Petroleum Products

  • Sarah Johann,
  • Mira Goßen,
  • Peter A. Behnisch,
  • Henner Hollert and
  • Thomas-Benjamin Seiler

26 June 2020

Genotoxicity assessment is of high relevance for crude and refined petroleum products, since oil compounds are known to cause DNA damage with severe consequences for aquatic biota as demonstrated in long-term monitoring studies. This study aimed at t...

  • Article
  • Open Access
15 Citations
4,463 Views
16 Pages

Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan

  • Hyogo Horiguchi,
  • Etsuko Oguma,
  • Satoshi Sasaki,
  • Kayoko Miyamoto,
  • Yoko Hosoi,
  • Akira Ono and
  • Fujio Kayama

17 June 2020

Akita prefecture is located in the northern part of Japan and has many cadmium-polluted areas. We herein performed an exposure assessment of cadmium in 712 and 432 female farmers in two adjacent cadmium-polluted areas (A and B, respectively), who und...

  • Article
  • Open Access
46 Citations
4,358 Views
9 Pages

Per- and Polyfluoroalkyl Substances in Early Pregnancy and Risk for Preeclampsia: A Case-Control Study in Southern Sweden

  • Lars Rylander,
  • Christian H. Lindh,
  • Stefan R. Hansson,
  • Karin Broberg and
  • Karin Källén

16 June 2020

Preeclampsia is one of the most common causes of perinatal and maternal morbidity/mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per- and polyfluoroalkyl substances (PFAS). The present case-c...

  • Review
  • Open Access
60 Citations
12,433 Views
20 Pages

15 June 2020

Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential ad...

  • Feature Paper
  • Review
  • Open Access
113 Citations
29,023 Views
21 Pages

3 June 2020

Cannabidiol (CBD) is a naturally occurring, non-psychotropic cannabinoid of the hemp plant Cannabis sativa L. and has been known to induce several physiological and pharmacological effects. While CBD is approved as a medicinal product subject to pres...

  • Article
  • Open Access
15 Citations
3,866 Views
10 Pages

Sequential Extraction of Potentially Toxic Metals: Alteration of Method for Cu-Ni Polluted Peat Soil of Industrial Barren

  • Marina V. Slukovskaya,
  • Irina P. Kremenetskaya,
  • Svetlana V. Drogobuzhskaya and
  • Andrey I. Novikov

2 June 2020

An evaluation of fraction composition and transformation of metal compounds emitted by metal ore processing enterprises and accumulated in soils is crucial for assessing the environmental risks of pollution and ecosystem benefit of remediation. The a...

  • Review
  • Open Access
286 Citations
17,939 Views
39 Pages

2 June 2020

Microplastics have become one of the leading environmental threats due to their persistence, ubiquity and intrinsic toxic potential. The potential harm that microplastics impose on ecosystems varies from direct effects (i.e., entanglement and ingesti...

  • Article
  • Open Access
9 Citations
5,141 Views
10 Pages

E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis

  • Anas A. Ashour,
  • Hashim Alhussain,
  • Umar Bin Rashid,
  • Labiba Abughazzah,
  • Ishita Gupta,
  • Ahmed Malki,
  • Semir Vranic and
  • Ala-Eddin Al Moustafa

27 May 2020

E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular systems in humans...

  • Article
  • Open Access
242 Citations
11,255 Views
12 Pages

Effects of Co-Contamination of Microplastics and Cd on Plant Growth and Cd Accumulation

  • Fayuan Wang,
  • Xiaoqing Zhang,
  • Shuqi Zhang,
  • Shuwu Zhang,
  • Catharine A. Adams and
  • Yuhuan Sun

20 May 2020

Microplastics (MPs) occur widely in terrestrial ecosystems. However, information on the interaction of MPs with metals in terrestrial ecosystems is lacking in the literature. The present study investigated the effects of two types of MPs (high-densit...

  • Article
  • Open Access
135 Citations
11,467 Views
11 Pages

15 May 2020

Much of the seafood that humans consume comes from estuaries and coastal areas where microplastics (MPs) accumulate, due in part to continual input and degradation of plastic litter from rivers and runoff. As filter feeders, oysters (Crassostrea virg...

  • Article
  • Open Access
5 Citations
4,995 Views
13 Pages

Effect of Exposure of Plastic Infant Feeding Bottle Leached Water on Biochemical, Morphological and Oxidative Stress Parameters in Rats

  • Mahendra K. Pant,
  • Abul H. Ahmad,
  • Manisha Naithani,
  • Hari S. Pandey,
  • Monika Pandey and
  • Jayanti Pant

13 May 2020

Bisphenol A (BPA) is leached out from plastic infant feeding bottles that are filled with warm milk/water due to high temperatures, exposing the infants to BPA. The present study aims to understand the effects of ingestion of BPA leached from plastic...

  • Article
  • Open Access
7 Citations
5,615 Views
14 Pages

A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae

  • Jeongah Song,
  • Kojo Eghan,
  • Sangwoo Lee,
  • Jong-Su Park,
  • Seokjoo Yoon,
  • Wittaya Pimtong and
  • Woo-Keun Kim

Polyhexamethylene guanidine-phosphate (PHMG-P), a guanidine-based cationic antimicrobial polymer, is an effective antimicrobial biocide, potent even at low concentrations. Due to its resilient bactericidal properties, it has been used extensively in...

  • Article
  • Open Access
25 Citations
4,557 Views
12 Pages

Contamination of shooting ranges by heavy metals in particular Pb represents a widespread environmental issue attracting concern worldwide. Contaminant accumulation in shooting range soils can pose potential ecological risks and health risks for shoo...

  • Article
  • Open Access
10 Citations
6,952 Views
14 Pages

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats

  • Alejandro Monserrat García-Alegría,
  • Agustín Gómez-Álvarez,
  • Iván Anduro-Corona,
  • Armando Burgos-Hernández,
  • Eduardo Ruíz-Bustos,
  • Rafael Canett-Romero,
  • Humberto González-Ríos,
  • José Guillermo López-Cervantes,
  • Karen Lillian Rodríguez-Martínez and
  • Humberto Astiazaran-Garcia

20 April 2020

Recently, soluble forms of aluminum for human use or consumption have been determined to be potentially toxic due to their association with hepatic, neurological, hematological, neoplastic, and bone conditions. This study aims to assess the genotoxic...

  • Article
  • Open Access
5 Citations
4,210 Views
16 Pages

15 April 2020

Oral glucose tolerance tests, in which the concentration of glucose is monitored in the circulation over 2 h after ingesting a bolus, probe diabetic or pre-diabetic conditions. The resulting glucose curves inform about glucose turnover, insulin produ...

  • Article
  • Open Access
63 Citations
10,012 Views
10 Pages

Effect of 10 UV Filters on the Brine Shrimp Artemia salina and the Marine Microalga Tetraselmis sp.

  • Evane Thorel,
  • Fanny Clergeaud,
  • Lucie Jaugeon,
  • Alice M. S. Rodrigues,
  • Julie Lucas,
  • Didier Stien and
  • Philippe Lebaron

10 April 2020

The presence of pharmaceutical and personal care product (PPCP) residues in the aquatic environment is an emerging issue due to their uncontrolled release through gray water, and accumulation in the environment that may affect living organisms, ecosy...

  • Article
  • Open Access
21 Citations
5,360 Views
13 Pages

Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes

  • Dabor Resiere,
  • Hatem Kallel,
  • Odile Oxybel,
  • Cyrille Chabartier,
  • Jonathan Florentin,
  • Yannick Brouste,
  • Papa Gueye,
  • Bruno Megarbane and
  • Hossein Mehdaoui

9 April 2020

The epidemiology of severe acute poisonings in the French overseas departments of the Americas remains poorly reported. The main objective of this study was to determine the epidemiology and characteristics of severe acutely poisoned adult patients....

  • Feature Paper
  • Article
  • Open Access
66 Citations
12,606 Views
12 Pages

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI)

  • Thivanka Muthumalage,
  • Michelle R. Friedman,
  • Matthew D. McGraw,
  • Gary Ginsberg,
  • Alan E. Friedman and
  • Irfan Rahman

3 April 2020

The Centers for Disease Control declared e-cigarette, or vaping, product use-associated lung injury (EVALI) a national outbreak due to the high incidence of emergency department admissions and deaths. We have identified chemical constituents in e-cig...

  • Article
  • Open Access
56 Citations
6,969 Views
16 Pages

3 April 2020

Nano-scale zero-valent iron (nZVI) is among the most common nanoparticles widely used for the treatment of various environmental contaminants. However, little is known about the combined effects of nano-zero-valent iron (nZVI) and other soil amendmen...

  • Article
  • Open Access
4 Citations
3,860 Views
9 Pages

1 April 2020

Perfluoroalkyl carboxylic acids (PFCAs), such as perfluorooctanoic acid (PFOA, C8), are a group of industrial chemicals that are detected in the serum of people throughout the world. Long-chain PFCAs (C9 to C13) have high lipophilicity, therefore the...

  • Article
  • Open Access
10 Citations
4,410 Views
12 Pages

In Vitro Evaluation of the Effects of Cadmium on Endocytic Uptakes of Proteins into Cultured Proximal Tubule Epithelial Cells

  • Hitomi Fujishiro,
  • Hazuki Yamamoto,
  • Nobuki Otera,
  • Nanae Oka,
  • Mei Jinno and
  • Seiichiro Himeno

1 April 2020

Cadmium (Cd) is an environmental pollutant known to cause dysfunctions of the tubular reabsorption of biomolecules in the kidney. Elevated levels of urinary excretion of low-molecular-weight proteins such as β2-microglobulin (β2-MG) have be...

  • Perspective
  • Open Access
57 Citations
10,148 Views
16 Pages

25 March 2020

Environmental toxicants have been implicated in neurodegenerative diseases, and pesticide exposure is a suspected environmental risk factor for Alzheimer’s disease (AD). Several epidemiological analyses have affirmed a link between pesticides a...

  • Article
  • Open Access
98 Citations
15,054 Views
13 Pages

‘The Plastic Nile’: First Evidence of Microplastic Contamination in Fish from the Nile River (Cairo, Egypt)

  • Farhan R. Khan,
  • Yvonne Shashoua,
  • Alex Crawford,
  • Anna Drury,
  • Kevin Sheppard,
  • Kenneth Stewart and
  • Toby Sculthorp

25 March 2020

The presence of microplastics (MPs) in the world’s longest river, the Nile River, has yet to be reported. This small-scale study aimed to provide the first information about MPs in the Nile River by sampling the digestive tracts of two fish spe...

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Toxics - ISSN 2305-6304