Special Issue "Toxic Metals, Chronic Diseases and Related Cancers"
Deadline for manuscript submissions: 31 July 2020.
Interests: epidemiology of cadmium toxicity; genetic and nutritional influence of cadmium toxicity outcomes; cadmium toxicity in at-risk subpopulations; novel methods of measuring cadmium in tissues; reverse dosimetry
Special Issues and Collections in MDPI journals
It is estimated that 70–90% of the risk of acquiring chronic diseases such as kidney disease, type-2 diabetes, and cancers can be attributed to environmental exposures. The toxic heavy metals, cadmium (Cd), lead (Pb), and mercury (Hg) are of particular public health concern and this is reflected by the World Health Organization (WHO) and the Agency for Toxic Substances and Disease Registry (ATSDR) listing them as priority substances.
Years of production and industrial use have led to the widespread presence of these metals in the environment. Being non-biodegradable, they persist in the environment and readily enter food chains. The continued use of contaminated fertilizers by the agricultural sector has further increased their levels in the food we eat. Total diet studies have shown that Cd and Pb are present in virtually all foodstuffs, while mercury is present in seafood in the form of methylmercury. Foods that are frequently consumed in large quantities such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops are the most significant dietary sources, while shellfish, crustaceans, mollusks, offal, and spinach are additional dietary sources.
Given the globally rising incidence of chronic kidney disease, Alzheimer’s disease, type-2 diabetes, and cancer of various sites, this Toxics Special Issue calls for reports on epidemiologic and laboratory investigations that may help prioritize efforts to assess toxicities and the impact of these environmental toxicants on public health. Topics may include intestinal absorption, transport, cellular uptake, metabolic effects, novel toxicity targets, toxic threshold levels, toxic mechanisms, detoxification, speciation, mitigation of soil-to-plant transference, and environmental exposure minimization strategies. Authors are invited and welcome to submit original research papers, reviews, and short communications.
Prof. Soisungwan Satarug
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Chronic diseases
- Metal transporters
- Metabolic syndrome
- Soil-to-plant transfer
- Tolerable intake levels
- Total diet studies
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Chronic low-level environmental exposure to cadmium and lead: Focus on their nephrotoxicity and carcinogenicity
Authors: Soisungwan Satarug, David A. Vesey, Glenda C. Gobe, and Kenneth R. Phelps
Chronic kidney disease (CKD) is the cause of significant morbidity and mortality. Its high worldwide prevalence and escalating treatment costs have made developing strategies to prevent CKD of global importance. Cadmium (Cd) and lead (Pb) are toxicants of relevance due to their widespread pollution, non-biodegradability and the known adverse health effects, including enhanced risk of CKD, diabetes and various types of cancer. Years of production and industrial use have mobilized Cd and Pb from non-bioavailable geologic matrices to where they are biologically accessible and readily enter food chains. The use of contaminated fertilizers has further increased Cd and Pb levels in food crops. Plants have the propensity to concentrate Cd and Pb from the soil and their multiple detoxification mechanisms enable them to tolerate high Cd and Pb levels that are toxic to animals and humans. The goal of this review is to provide a rational for public health policy regarding exposure limits, tolerable intake levels and the modification of the current criteria by which Cd- and Pb-induced nephrotoxicity is judged. Accordingly, dietary sources and intake levels of Cd and Pb reported by total diet studies are summarized together with urinary biomarkers, N-acetyl-β-D-glucosaminidase and β2-microglobulin (β2MG) which are often used to assess nephrotoxicity. The relationship between tubulopathy and decreased glomerular filtration rate is discussed as is the basis for urinary β2MG excretion as an indicator of nephron loss. The effects of environmental exposure to Cd and Pb on the risk of CKD and cancer reported in recent epidemiologic studies are summarized.
Keywords: cadmium; cancer; chronic kidney disease; glomerular filtration rate; lead; nephron loss; urine β2-microglobulin