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Open AccessFeature PaperArticle

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI)

Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
Department of Chemistry & Biochemistry, The College of Brockport, State University of New York, Brockport, NY 14420, USA
Division of Pediatric Pulmonology, University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY 14642, USA
New York State Department of Health, Center for Environmental Health, Albany, NY 12237, USA
Department of Materials Design and Innovation, School of Engineering and Applied Sciences, University at Buffalo, Buffalo, NY 14260, USA
Author to whom correspondence should be addressed.
Toxics 2020, 8(2), 25;
Received: 9 March 2020 / Accepted: 30 March 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Current Knowledge of E-cigarettes and Heated Tobacco Products)
The Centers for Disease Control declared e-cigarette, or vaping, product use-associated lung injury (EVALI) a national outbreak due to the high incidence of emergency department admissions and deaths. We have identified chemical constituents in e-cig counterfeit cartridges and compared these to medical-grade and CBD containing cartridges. Apart from vitamin E acetate (VEA) and tetrahydrocannabinol (THC), other potential toxicants were identified including solvent-derived hydrocarbons, silicon conjugated compounds, various terpenes, pesticides/plasticizers/polycaprolactones, and metals. This study provides additional insights into the chemicals associated with EVALI cartridges and thus may contribute to the underlying disease mechanism of acute lung injury. View Full-Text
Keywords: Vaping; EVALI; VAPI; e-cigarette; THC; cannabis; lipoid-pneumonia Vaping; EVALI; VAPI; e-cigarette; THC; cannabis; lipoid-pneumonia
MDPI and ACS Style

Muthumalage, T.; Friedman, M.R.; McGraw, M.D.; Ginsberg, G.; Friedman, A.E.; Rahman, I. Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI). Toxics 2020, 8, 25.

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