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Open AccessArticle

Effect of Exposure of Plastic Infant Feeding Bottle Leached Water on Biochemical, Morphological and Oxidative Stress Parameters in Rats

1
Department of Anatomy, Government Doon Medical College, Dehradun, Uttarakhand 248001, India; [email protected]
2
Department of Veterinary Pharmacology & Toxicology, College of Veterinary & Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand 263145, India
3
Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India
4
Department of Pathology, Government Doon Medical College, Dehradun, Uttarakhand 248001, India; [email protected]
5
Department of Physiology, Government Medical College, Haldwani, Uttarakhand 263139, India
6
Department of Physiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India
*
Author to whom correspondence should be addressed.
Toxics 2020, 8(2), 34; https://doi.org/10.3390/toxics8020034
Received: 2 April 2020 / Revised: 5 May 2020 / Accepted: 12 May 2020 / Published: 13 May 2020
(This article belongs to the Section Toxicology and Public Health)
Bisphenol A (BPA) is leached out from plastic infant feeding bottles that are filled with warm milk/water due to high temperatures, exposing the infants to BPA. The present study aims to understand the effects of ingestion of BPA leached from plastic infant feeding bottle and delineate the underlying mechanisms in rats. In this study, adult rats of Wistar strain were divided into 3 groups. In the first group, the rats consumed normal food and tap water ad libitum. In the second group, the rats ingested BPA (20 µg/kg bodyweight/day, orally). In the third group, the rats drank water leached from plastic infant feeding bottles. After 30days, tests involving biochemical parameters, histopathological examination, and oxidative stress enzyme markers were performed, and the levels of BPA in plastic-leached water were estimated by HPLC analysis. There were significant biochemical changes in the form of increased alkaline phosphatase (ALP), creatine kinase-muscle/brain (CK-MB), and lactate dehydrogenase (LDH) levels in both treated groups as compared to control group, accompanied by structural damage to the vital organs, and lipid peroxidation, glutathione reductase, and catalase activity were also high in the treated groups. Further, the BPA concentration in plastic leached water was estimated to be 0.1 ± 0.02 µg/mL. View Full-Text
Keywords: serum analysis; BPA; plastic leached water; oxidative stress; infant feeding bottles serum analysis; BPA; plastic leached water; oxidative stress; infant feeding bottles
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MDPI and ACS Style

Pant, M.K.; Ahmad, A.H.; Naithani, M.; Pandey, H.S.; Pandey, M.; Pant, J. Effect of Exposure of Plastic Infant Feeding Bottle Leached Water on Biochemical, Morphological and Oxidative Stress Parameters in Rats. Toxics 2020, 8, 34.

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