Special Issue "Health Effects Associated with Exposures to Endocrine Disrupting Chemicals"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editors

Dr. Zeyan Liew
Guest Editor
Department of Environmental Health Sciences, Yale School of Public Health, 1 Church Street, New Haven, CT 06510, USA
Interests: Acetaminophen; Attention Deficit Disorder with Hyperactivity; Child Development; Environmental Pollutants; Models, Statistical; Causality; Pharmacoepidemiology; Endocrine Disruptors; Pediatric Obesity; Autism Spectrum Disorder
Dr. Gunnar Toft
Guest Editor
Department of Clinical Epidemiology, Aarhus University, Olof Palmes Allé 43-45, 8200 Aarhus, Denmark
Interests: Epidemiology; Biomarkers; Reproductive Toxicology

Special Issue Information

Dear Colleagues,

Accruing research shows that human exposures to a wide range of endocrine disrupting chemicals (EDCs) could increase the risk of disease across the lifespan by altering the homeostasis or action of endogenous hormones, or other signaling chemicals of the endocrine system. Commonly investigated EDCs include chemicals widely applied in commercial and industrial products, such as per and polyfluoralkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), bisphenol A (BPA), phthalates, and certain pesticides. Pharmaceutical agents, including analgesics and painkillers such as acetaminophen, have also been suggested to exhibit strong endocrine disrupting effects. Our understanding of human health risks associated with exposure to EDCs remains limited. The early development period (i.e. in-utero, infancy, and childhood) might be more vulnerable to exposures to EDCs, but depending on the outcomes, relevant exposure windows may include additional periods throughout the entire lifespan.

In this Special Issue, we invite epidemiological research (original articles, reviews, and communications) that addresses human health risks associated with exposures to EDCs. Of interest to this issue are:

  1. Studies that investigate the associations between exposures to EDCs and human health risks, including but not limited to neurological, reproductive, endocrine, cardiovascular, or immunological outcomes. We encourage studies addressing critical time windows of exposure. In addition to ‘classical’ EDCs, we also encourage studies focusing on less studied chemicals or newer types of compounds that might be classified as EDCs;
  2. Research addressing biological pathways or mechanisms of EDC exposure and adverse health outcomes, including genomic, epigenomic, metabolomic, and proteomic studies;
  3. Studies focusing on interacting or mixture effects of two or more types of EDCs. In addition to statistical modeling driven approaches, we encourage biologically driven approaches in which models also consider biological pathways and doses of exposures;
  4. Studies that characterize sources of exposures in a population-based setting;
  5. Studies that focus on minority health and health disparities relating to EDC exposures.

Dr. Zeyan Liew
Dr. Gunnar Toft
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • endocrine disrupting chemicals
  • epidemiology
  • adverse health impacts
  • critical time windows of exposure
  • mixture effects
  • sources of exposure
  • health disparities

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


Open AccessArticle
Per- and Polyfluoroalkyl Substances in Early Pregnancy and Risk for Preeclampsia: A Case-Control Study in Southern Sweden
Toxics 2020, 8(2), 43; https://doi.org/10.3390/toxics8020043 - 16 Jun 2020
Preeclampsia is one of the most common causes of perinatal and maternal morbidity/mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per- and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association [...] Read more.
Preeclampsia is one of the most common causes of perinatal and maternal morbidity/mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per- and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk of developing preeclampsia. The study included 296 women diagnosed with preeclampsia (cases) and 580 healthy pregnant women (controls). Maternal serum samples were obtained from a biobank of samples collected in early pregnancy in connection with screening for infections. Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) were analyzed using liquid chromatography-tandem-mass-spectrometry (LC/MS/MS). Among primiparous women, there were no differences in PFAS concentrations in early pregnancy between the cases and the controls whereas among multipara women, the cases had significantly higher concentrations of PFNA (median concentrations were 0.44 and 0.38 ng/mL, p = 0.04). When individual PFAS were categorized into quartiles and adjustment for potential confounders was performed, the women in the highest quartiles had no significant increased risks of developing preeclampsia as compared with women in the lowest category. In conclusion, the present study provides limited support for the hypothesized association between PFAS and preeclampsia in a population with relatively low exposure levels. Full article
Back to TopTop