Special Issue "Current knowledge of E-cigarettes and Heated Tobacco Products"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 15 November 2019.

Special Issue Editors

Guest Editor
Dr. Konstantinos Poulas

Department of Pharmacy, University of Patras, GR 26500, Patras, Greece
Website | E-Mail
Phone: +30 2610 699539
Interests: laboratory and clinical research on e-cigarettes; toxicological and preclinical studies on non-combustible products; cloning, expression, purification, and biochemical characterization of recombinant fragments; electroceuticals
Guest Editor
Dr. George Lagoumintzis

1. Department of Pharmacy, University of Patras, GR 26500, Patras, Greece
2. Lab of Health Physics and Computational Intelligence, Western Greece University, Greece
Interests: laboratory and clinical research on e-cigarettes; toxicological and preclinical studies on non-combustible products; immunology–microbiology; host defense; bio-electromagnetics
Guest Editor
Dr. Konstantinos Farsalinos

Department of Pharmacy, University of Patras, GR 26500, Patras, Greece
Phone: +30 6977 454837
Interests: laboratory and clinical research on e-cigarettes; cytotoxic effects of e-cigarette vapor on cultured cells; effects of e-cigarette use on cardiac function and coronary circulation

Special Issue Information

Dear Colleagues,

Tobacco smoking has been identified as the single most important source of preventable morbidity and premature mortality in financially developed countries. Electronic cigarettes are non-tobacco nicotine delivery devices, that are used by smokers as a substitute in an attempt to quit smoking. Heated tobacco products are newer tobacco harm reduction (THR) products that function by heating, instead of combusting, tobacco. Awareness and use of these devices have increased exponentially over the past few years.

To date, there is considerable controversy and disagreement on the efficacy of electronic cigarettes and other harm reduction products and devices in smoking cessation.

The aim of this Special Issue in Toxics, entitled “Current Knowledge of E-Cigarettes and Heated Tobacco Products”, is to highlight timely research studies addressing scientific, technological, and medical developments, as well as regulatory, legal, and policy issues on THR. Studies may include, but are not limited to original articles, expert reviews, short communications, opinion letters on debates, and any clinical and/or animal studies, aimed at better exploring the harm reduction concept, and advancing scientific knowledge. The submissions of hypotheses, opinions and commentaries, computational or modeling studies, and meta-analyses are also welcomed. 

Dr. Konstantinos Poulas
Dr. George Lagoumintzis
Dr. Konstantinos Farsalinos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • e-cigarettes
  • heated tobacco products
  • harm reduction
  • nicotine
  • tobacco
  • public health
  • smoking

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper 1: Article

Title: Shaping Health Policies Identifying and Analyzing Stakeholders Stances: Products that Reduce the Health Risks of Tobacco Use

Authors: Dimitrios N. Yfantis1, George Lagoumintzis1, Konstantinos Farsalinos1, Konstantinos Poulas1*, and Athanassios Vozikis2,*

Affiliation: 1Department of Pharmacy, School of Health Sciences, University of Patras, Greece 2Department of Economics, University of Piraeus, Greece

Abstract: Electronic cigarettes have been steadily increasing in popularity among young adults since their introduction to EU markets. E-cigarette companies are targeting many stakeholder groups including regulators, politicians, health bodies, etc. The purpose of our research was to test the feasibility to shape health policies in Greece, identifying and analyzing various agencies’ and organizations’ stances to alternative tobacco product use (e-cigarettes) among smokers, as a means to smoking cessation and tobacco harm recuction. Study Design: A stakeholder analysis study was conducted. We used the sophisticated digital tool PolicyMaker for health policy making. It served as a means of collecting and organising important information about the major groups involved with the policy, such as their level and area of activity, their initial position, their influence and their interests. Our results show that most of the stakeholders express positive opinions about e-cigarettes and support their use as an alternative means of ceasing or reducing smoking. The highly opposed groups seem to form their initial positions due to financial reasons. The main current obstacle in Greece is the lack of financial resources. Despite this fact, our policy presents a significant probability of success. With the right strategies, there will be an increase in our policy’s supporters and a decrease in the intensity of some stakeholders’ opposition.

Type of Paper 2: Article

Title: Real-time assessment of e-cigarettes and conventional cigarettes emissions: Aerosol size distributions, mass and number concentrations

Authors: Spyros Lampos1, Evangelia Kostenidou2,#, Konstantinos Farsalinos1, Zoi Zagoriti1, Aristeidis Ntoukas1, Konstantinos Dalamarinis1, Panagiotis Savranakis1, George Lagoumintzis*1, Konstantinos Poulas*1,3,

Affiliation: 1 Department of Pharmacy, Laboratory of Molecular Biology & Immunology, University of Patras, 26500, Greece.

2 Institute of Chemical Engineering Sciences, ICE-HT, Patras, 26504, Greece.

# now at: Aix-Marseille Université, CNRS, LCE,13331, Marseille, France.

3 Institute for Research and Innovation Nosmoke.team, Patras Science Park, Patras, 26504, Greece.

Abstract: Cigarette smoke is a complex mixture of chemical compounds which are emitted during the processes of tobacco combustion. Electronic cigarettes (e-cigs) are expected to produce less harmful compounds due to the absence of tobacco leaf combustion. However, potential risks of the passive exposure to the aerosol exhaled by e-cig users have been raised in the last decade. In this study, the aerosols with diameter less than 1 μm (PM1) produced by vaping of various e-cig liquids were compared to those generated by smoking conventional cigarettes in real-time. The mass and number concentration along with the number size distribution were measured in a closed room of 35 m3 volume. Our results showed that aerosol emitted from e-cig liquids had a different profile compared to the conventional cigarettes. Although e-cigs initially produced higher particle mass and number concentrations, they had much shorter life time of approximately 10-20 seconds, in comparison with the conventional and hand-rolling cigarette particulate emissions which had a dissipation time of approximately 1.4 h in a 35 m3 room. E-cigs emitted aerosols which volatilized rapidly, as they probably consist almost only of propylene glycol and/or vegetable glycerin.

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