Biological Fate and Potential Hazards of Per- and Polyfluorinated Alkyl Substances (PFAS)
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Emerging Contaminants".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 47282
Special Issue Editors
Interests: environmental science; immunotoxicology; neurotoxicology; developmental toxicology; emerging contaminants; risk assessment
Special Issues, Collections and Topics in MDPI journals
Interests: environmental engineering; toxicokinetics; molecular modeling; bioaccumulation; emerging contaminants; hazard assessment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Per- and polyfluoroalkyl substances (PFAS) are synthetic compounds used to produce industrial and consumer goods, notably as surfactants and to produce surface coatings that confer stain-, water-, and oil-repellency. PFAS are extremely stable compounds due to the strength of the carbon-fluorine bond and, as a result, are persistent across environmental media. Some PFAS also accumulate and produce adverse health effects within living organisms, which has led to the phase-out of long-chain perfluorinated acids. Recently produced replacement compounds, which include PFAS with carbon chain lengths less than six or eight carbons and those with ether linkages, are also highly mobile and may travel to points distant from their points of release.
These characteristics of persistence, bioaccumulation, mobility, and toxicity, combined with a large number of individual PFAS, create numerous challenges for assessing the hazards of PFAS exposure. Therefore, describing toxicodynamic and toxicokinetic features of sub-groups of PFAS, uncovering mechanisms by which PFAS induce toxicity, and moving toward biological assays that allow for read-across or the development of adverse outcome pathways will be fundamental for making sound decisions about PFAS remediation, exposure mitigation, and health impacts.
For this Special Issue, we invite high-quality original research papers, short communications, and reviews focusing on all aspects of hazard assessment of PFAS. Studies may be in vivo, in vitro, or in silico and explore strategies for in vitro or in silico to in vivo extrapolation (IVIVE or ISIVE). We welcome experimental models, wildlife investigations, and computational and predictive studies. Research on single PFAS, PFAS mixtures, and complex environmental samples are welcome.
Dr. Jamie DeWitt
Dr. Carla Ng
Guest Editors
Manuscript Submission Information
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Keywords
- PFAS
- bioaccumulation
- toxicity
- uptake
- toxicodynamics
- toxicokinetics
- half-life
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