Special Issue "Contaminant Effects on Zebrafish Embryos"
A special issue of Toxics (ISSN 2305-6304).
Deadline for manuscript submissions: closed (30 November 2019).
Interests: Physiologically-based toxicokinetic modelling; Inter-species extrapolation of uptake and effects of contaminants in fish; Influence of environmental factors on the bioavailability of environmental contaminants to aquatic organisms
Interests: Animal alternatives based on zebrafish embryos; Analysis of embryotoxicity, teratogenicity, and mechanistic effects in zebrafish embryos; Zebrafish as model species in human toxicology
In the past decades, the early-life stages of the zebrafish (Danio rerio) have become an important model system in biomedical research. Apart from being easy to culture and breed under laboratory conditions, zebrafish exhibit virtually transparent embryos and their genome has been systematically sequenced and annotated since 2001, making them valuable models in developmental and genetic research. These advantages have also made them a popular species in toxicological research, and the fish embryo toxicity test (FET) test has since replaced acute fish tests for whole-effluent testing in several countries globally. In fact, since fish embryos are believed to be non-sentient, the FET test is not considered an animal experiment in many legislations. With the adoption of an OECD FET test guideline for chemical testing (OECD 236) in 2013, it is expected that this test will soon be the gold standard for assessments of acute embryotoxicity and teratogenicity and might eventually replace acute fish tests altogether.
The most recent and innovative toxicological research using zebrafish embryos, however, goes far beyond these classical endpoints. In addition to ecotoxicogenomics, research on neurotoxic and behavioral effects has been facilitated by the availability of economic and user-friendly video tracking systems, and advances in mass-spectrometry have enabled single-embryo proteomic, metabolomic and bioaccumulation research. With the growing popularity of CRISPR/Cas9 for targeted genome editing, we can only speculate regarding the ground-breaking research we will witness in the upcoming decades.
For this Special Issue, we invite high-quality original research papers, short communications and reviews focussing on contaminant effects on zebrafish embryos. Studies may include, but are not limited to classical and modern endpoints, wild-type and genetically modified strains, studies related to environmental and human health impacts, research on single chemicals, mixtures and complex environmental samples. We welcome computational or predictive studies and meta-analyses.
Dr. Markus Brinkmann
Dr. Sabrina Schiwy
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Developmental Biology
- Mechanism-specific Effects
- Behavioral Effects
- Life Stage Extrapolation