You are currently viewing a new version of our website. To view the old version click .

Metabolites, Volume 11, Issue 4

April 2021 - 64 articles

Cover Story: Streptomyces bacteria produce numerous specialized metabolites with industrial and medicinal applications, and they contain many associated biosynthetic gene clusters (BGCs). However, the products of many such BGCs remain unknown as the associated metabolites are produced at either low levels or not at all under laboratory settings. Therefore, we overexpressed the ribosome-recycling factor, ribosomal protein S12, and three S12 variants in Streptomyces clavuligerus to enhance the production of such metabolites. Untargeted metabolomics, in combination with molecular networking and in silico structure prediction, alluded to 28 previously unreported metabolites from S. clavuligerus along with associated BGCs in some cases. Overall, the described strategy can help in the identification of candidate structures to aid novel natural product discovery endeavors. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (64)

  • Article
  • Open Access
23 Citations
6,235 Views
15 Pages

Streamlined Multimodal DESI and MALDI Mass Spectrometry Imaging on a Singular Dual-Source FT-ICR Mass Spectrometer

  • Kevin J. Zemaitis,
  • Alexandra M. Izydorczak,
  • Alexis C. Thompson and
  • Troy D. Wood

20 April 2021

The study of biological specimens by mass spectrometry imaging (MSI) has had a profound influence in the various forms of spatial-omics over the past two decades including applications for the identification of clinical biomarker analysis; the metabo...

  • Systematic Review
  • Open Access
25 Citations
3,930 Views
12 Pages

20 April 2021

Treatment of older patients with benzodiazepines and Z-drugs (BZRA) is associated with an increased risk of side effects. However, this treatment is still used among these patients. Deprescribing can be a tool to reduce inappropriate medication. This...

  • Review
  • Open Access
183 Citations
38,256 Views
33 Pages

Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment

  • Ligia J. Dominguez,
  • Mario Farruggia,
  • Nicola Veronese and
  • Mario Barbagallo

20 April 2021

Studies on vitamin/hormone D deficiency have received a vast amount of attention in recent years, particularly concerning recommendations, guidelines, and treatments. Moreover, vitamin D’s role as a hormone has been confirmed in various enzymatic, me...

  • Article
  • Open Access
12 Citations
3,219 Views
16 Pages

Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management

  • Lise Bernard,
  • Yassine Bouattour,
  • Morgane Masse,
  • Benoît Boeuf,
  • Bertrand Decaudin,
  • Stéphanie Genay,
  • Céline Lambert,
  • Emmanuel Moreau,
  • Bruno Pereira and
  • Jérémy Pinguet
  • + 3 authors

19 April 2021

Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposu...

  • Article
  • Open Access
23 Citations
4,026 Views
18 Pages

Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques

  • Francesco Greco,
  • Laura Quercioli,
  • Angela Pucci,
  • Silvia Rocchiccioli,
  • Mauro Ferrari,
  • Fabio A. Recchia and
  • Liam A. McDonnell

18 April 2021

Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events. The investigation of atherosclerotic plaques is made difficult by th...

  • Review
  • Open Access
40 Citations
8,169 Views
36 Pages

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

  • Maria Michelle Papamichael,
  • Charis Katsardis,
  • Evangelia Sarandi,
  • Spyridoula Georgaki,
  • Eirini-Sofia Frima,
  • Anastasia Varvarigou and
  • Dimitris Tsoukalas

18 April 2021

Asthma in children remains a significant public health challenge affecting 5–20% of children in Europe and is associated with increased morbidity and societal healthcare costs. The high variation in asthma incidence among countries may be attributed...

  • Article
  • Open Access
14 Citations
3,050 Views
22 Pages

17 April 2021

Previous cross-sectional metabolomics studies have identified many potential dietary biomarkers, mostly in blood. Few studies examined urine samples although urine is preferred for dietary biomarker discovery. Furthermore, little is known regarding t...

  • Article
  • Open Access
9 Citations
3,528 Views
12 Pages

Changes of Hematological and Hemorheological Parameters in Rabbits with Hypercholesterolemia

  • Bence Tanczos,
  • Viktoria Somogyi,
  • Mariann Bombicz,
  • Bela Juhasz,
  • Norbert Nemeth and
  • Adam Deak

17 April 2021

Hypercholesterolemia plays an important role in the development of atherosclerosis, leading to endothelial dysfunction, ischemic events, and increased mortality. Numerous studies suggest the pivotal role of rheological factors in the pathology of ath...

  • Article
  • Open Access
15 Citations
3,779 Views
11 Pages

Metabolic Mechanism of Plant Defense against Rice Blast Induced by Probenazole

  • Zhaochen Wu,
  • Guozhen Wang,
  • Borui Zhang,
  • Tan Dai,
  • Anyu Gu,
  • Xiaolin Li,
  • Xingkai Cheng,
  • Pengfei Liu,
  • Jianjun Hao and
  • Xili Liu

16 April 2021

The probenazole fungicide is used for controlling rice blast (Magnaporthe grisea) primarily by inducing disease resistance of the plant. To investigate the mechanism of induced plant defense, rice seedlings were treated with probenazole at 15 days po...

  • Article
  • Open Access
6 Citations
3,803 Views
12 Pages

Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis

  • Hongshuai Li,
  • Aiping Lu,
  • Xueqin Gao,
  • Ying Tang,
  • Sudheer Ravuri,
  • Bing Wang and
  • Johnny Huard

16 April 2021

Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis...

of 7

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Metabolites - ISSN 2218-1989Creative Common CC BY license