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Antibiotics, Volume 10, Issue 8

August 2021 - 142 articles

Cover Story: Treatment of infections by the sexually transmitted pathogen Mycoplasma genitalium is hampered by the rapidly increasing resistance to the recommended antibiotics. Thus, resistance-guided therapy (RGT) is key for successful eradication. In this context, typing of strains is helpful to distinguish between ongoing colonization, re-infection, or development of resistance. MgpB and MG_309 types, as well as mutations associated with macrolide, quinolone, and tetracycline resistance of strains in M. genitalium-positive samples accumulated at a university hospital were analyzed. Twenty-three mgpB types, nine MG_309 types and 34 mgpB/MG_309 types were identified. The prevalence of mutations associated with macrolide, quinolone, and tetracycline resistance was 56.9%, 10.3%, and 6.8%, respectively. The rate of successful eradication (93.3%) is promising for continuation of the RGT strategy. View this paper.
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Articles (142)

  • Article
  • Open Access
8 Citations
3,634 Views
12 Pages
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Molecular Detection, Serotyping, and Antibiotic Resistance of Shiga Toxigenic Escherichia coli Isolated from She-Camels and In-Contact Humans in Egypt

  • Mohamed Said Diab,
  • Reda Tarabees,
  • Yasser F. Elnaker,
  • Ghada A. Hadad,
  • Marwa A. Saad,
  • Salah A. Galbat,
  • Sarah Albogami,
  • Aziza M. Hassan,
  • Mahmoud A. O. Dawood and
  • Sabah Ibrahim Shaaban
Antibiotics2021, 10(8), 1021;https://doi.org/10.3390/antibiotics10081021

23 August 2021

This study aims to determine the prevalence of STEC in she-camels suffering from mastitis in semi-arid regions by using traditional culture methods and then confirming it with Serological and molecular techniques in milk samples, camel feces, as well...

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  • Article
  • Open Access
15 Citations
3,530 Views
19 Pages
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Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities

  • Laura Treiber,
  • Christine Pezolt,
  • Haoxuan Zeng,
  • Hedda Schrey,
  • Stefan Jungwirth,
  • Aditya Shekhar,
  • Marc Stadler,
  • Ursula Bilitewski,
  • Maike Erb-Brinkmann and
  • Rainer Schobert
Antibiotics2021, 10(8), 1022;https://doi.org/10.3390/antibiotics10081022

23 August 2021

Eight analogues of the bioherbicides macrocidin A (1) and Z (2) with structural variance in the size of the macrocycle, its para- or meta-cyclophane character, and its functional groups were synthesized on two modular routes and tested for herbicidal...

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  • Article
  • Open Access
19 Citations
7,187 Views
14 Pages
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Synergistic Antibacterial Effects of Meropenem in Combination with Aminoglycosides against Carbapenem-Resistant Escherichia coli Harboring blaNDM-1 and blaNDM-5

  • Pawarisa Terbtothakun,
  • Ozioma Forstinus Nwabor,
  • Thanyaluck Siriyong,
  • Supayang P. Voravuthikunchai and
  • Sarunyou Chusri
Antibiotics2021, 10(8), 1023;https://doi.org/10.3390/antibiotics10081023

23 August 2021

Infections due to carbapenem-resistant Escherichia coli (CREC) are problematic due to limitation in treatment options. Combination therapies of existing antimicrobial agents have become a reliable strategy to control these infections. In this study,...

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  • Article
  • Open Access
54 Citations
9,528 Views
15 Pages
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Dispensing Antibiotics without Prescription at Community Pharmacies and Accredited Drug Dispensing Outlets in Tanzania: A Cross-Sectional Study

  • Pendo M. Ndaki,
  • Martha F. Mushi,
  • Joseph R. Mwanga,
  • Eveline T. Konje,
  • Nyanda E. Ntinginya,
  • Blandina T. Mmbaga,
  • Katherine Keenan,
  • Wilber Sabiiti,
  • Mike Kesby and
  • Fernando Benitez-Paez
  • + 4 authors
Antibiotics2021, 10(8), 1025;https://doi.org/10.3390/antibiotics10081025

23 August 2021

Worldwide, antimicrobial resistance is increasing rapidly and is associated with misuse of antimicrobials. The HATUA study (a broader 3-country study) investigated the antibiotic dispensing practices of pharmaceutical providers to clients, particular...

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  • Article
  • Open Access
2 Citations
2,810 Views
8 Pages
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Characterization and Clonal Diffusion of Ceftaroline Non-Susceptible MRSA in Two Hospitals in Central Italy

  • Gianluca Morroni,
  • Simona Fioriti,
  • Federica Salari,
  • Andrea Brenciani,
  • Lucia Brescini,
  • Marina Mingoia,
  • Eleonora Giovanetti,
  • Antonella Pocognoli,
  • Andrea Giacometti and
  • Elisa Molinelli
  • + 3 authors
Antibiotics2021, 10(8), 1026;https://doi.org/10.3390/antibiotics10081026

23 August 2021

Background: Ceftaroline represents a novel fifth-generation cephalosporin to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Ceftaroline susceptibility of 239 MRSA isolates was assessed by disk diffusion and a...

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  • Article
  • Open Access
23 Citations
4,598 Views
14 Pages
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Plasma-Activated Saline Promotes Antibiotic Treatment of Systemic Methicillin-Resistant Staphylococcus aureus Infection

  • Lu Yang,
  • Gulimire Niyazi,
  • Yu Qi,
  • Zhiqian Yao,
  • Lingling Huang,
  • Zifeng Wang,
  • Li Guo and
  • Dingxin Liu
Antibiotics2021, 10(8), 1018;https://doi.org/10.3390/antibiotics10081018

22 August 2021

Systemic infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are life-threatening due to their strong multidrug resistance, especially since the biofilms formed by MRSA are more difficult to inactivate by antibiotics, causing long...

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  • Article
  • Open Access
8 Citations
4,211 Views
9 Pages
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Effects of Incubation Time and Inoculation Level on the Stabilities of Bacteriostatic and Bactericidal Antibiotics against Salmonella Typhimurium

  • Nana Nguefang Laure,
  • Jirapat Dawan and
  • Juhee Ahn
Antibiotics2021, 10(8), 1019;https://doi.org/10.3390/antibiotics10081019

22 August 2021

This study was designed to evaluate the stability of chloramphenicol, erythromycin, tetracycline, cephalothin, ciprofloxacin, and tobramycin against antibiotic-sensitive Salmonella Typhimurium (ASST) and antibiotic-resistant S. Typhimurium (ARST) dur...

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  • Article
  • Open Access
6 Citations
5,303 Views
10 Pages
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Anti-MRSA Cephalosporin versus Vancomycin-Based Treatment for Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Ching-Yi Chen,
  • Wang-Chun Chen,
  • Chih-Cheng Lai,
  • Tzu-Ping Shih and
  • Hung-Jen Tang
Antibiotics2021, 10(8), 1020;https://doi.org/10.3390/antibiotics10081020

22 August 2021

This systematic review and meta-analysis of randomized controlled trials (RCTs) compared the clinical efficacy and safety of anti-MRSA cephalosporin and vancomycin-based treatment in treating acute bacterial skin and skin structure infections (ABSSSI...

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  • Article
  • Open Access
24 Citations
5,631 Views
16 Pages
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Phage Targeting Streptococcus mutans In Vitro and In Vivo as a Caries-Preventive Modality

  • Amit Wolfoviz-Zilberman,
  • Reut Kraitman,
  • Ronen Hazan,
  • Michael Friedman,
  • Yael Houri-Haddad and
  • Nurit Beyth
Antibiotics2021, 10(8), 1015;https://doi.org/10.3390/antibiotics10081015

21 August 2021

Dental caries is a common infectious disease worldwide. Current conventional therapies lack specific antimicrobial effects against Streptococcus mutans, a key bacterium that induces caries. A promising alternative approach is bacteriophage (phage) th...

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