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Antibiotics, Volume 10, Issue 8

August 2021 - 142 articles

Cover Story: Treatment of infections by the sexually transmitted pathogen Mycoplasma genitalium is hampered by the rapidly increasing resistance to the recommended antibiotics. Thus, resistance-guided therapy (RGT) is key for successful eradication. In this context, typing of strains is helpful to distinguish between ongoing colonization, re-infection, or development of resistance. MgpB and MG_309 types, as well as mutations associated with macrolide, quinolone, and tetracycline resistance of strains in M. genitalium-positive samples accumulated at a university hospital were analyzed. Twenty-three mgpB types, nine MG_309 types and 34 mgpB/MG_309 types were identified. The prevalence of mutations associated with macrolide, quinolone, and tetracycline resistance was 56.9%, 10.3%, and 6.8%, respectively. The rate of successful eradication (93.3%) is promising for continuation of the RGT strategy. View this paper.
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Articles (142)

  • Article
  • Open Access
18 Citations
5,135 Views
10 Pages

Trends of Multidrug-Resistant Pathogens, Difficult to Treat Bloodstream Infections, and Antimicrobial Consumption at a Tertiary Care Center in Lebanon from 2015–2020: COVID-19 Aftermath

  • Amanda Chamieh,
  • Rita Zgheib,
  • Sabah El-Sawalhi,
  • Laure Yammine,
  • Gerard El-Hajj,
  • Omar Zmerli,
  • Claude Afif,
  • Jean-Marc Rolain and
  • Eid Azar

Introduction: We studied the trend of antimicrobial resistance and consumption at Saint George Hospital University Medical Center (SGHUMC), a tertiary care center in Beirut, Lebanon, with a focus on the SARS-CoV-2 pandemic. Materials and Methods: We...

  • Article
  • Open Access
8 Citations
3,340 Views
12 Pages

Thermal Shock and Ciprofloxacin Act Orthogonally on Pseudomonas aeruginosa Biofilms

  • Haydar Aljaafari,
  • Yuejia Gu,
  • Hannah Chicchelly and
  • Eric Nuxoll

Bacterial biofilm infections are a major liability of medical implants, due to their resistance to both antibiotics and host immune response. Thermal shock can kill established biofilms, and some evidence suggests antibiotics may enhance this efficac...

  • Review
  • Open Access
45 Citations
9,171 Views
16 Pages

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of invasive infections, mainly bloodstream infections (BSI) with or without endocarditis. The purpose of this meta-analysis was to compare vancomycin, the mainstay t...

  • Review
  • Open Access
72 Citations
7,430 Views
13 Pages

Polyphenols and Organic Acids as Alternatives to Antimicrobials in Poultry Rearing: A Review

  • Federica Scicutella,
  • Federica Mannelli,
  • Matteo Daghio,
  • Carlo Viti and
  • Arianna Buccioni

For decades antibiotics have been used in poultry rearing to support high levels of production. Nevertheless, several problems have arisen because of the misuse of antibiotics (i.e., antibiotic resistance, residues in animal products, environmental p...

  • Article
  • Open Access
27 Citations
3,472 Views
14 Pages

Acinetobacter baumannii is a dangerous bacterial pathogen possessing the ability to persist on various surfaces, especially in clinical settings, and to rapidly acquire the resistance to a broad spectrum of antibiotics. Thus, the epidemiological surv...

  • Article
  • Open Access
59 Citations
6,726 Views
34 Pages

Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World

  • Muhammad Fayyaz ur Rehman,
  • Shahzaib Akhter,
  • Aima Iram Batool,
  • Zeliha Selamoglu,
  • Mustafa Sevindik,
  • Rida Eman,
  • Muhammad Mustaqeem,
  • Muhammad Safwan Akram,
  • Fariha Kanwal and
  • Changrui Lu
  • + 1 author

The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many efforts to find some effective medicines against SARS CoV-2, no established therapeutics are available yet. The use of phytochemicals as antiviral agents provides...

  • Review
  • Open Access
147 Citations
23,553 Views
32 Pages

Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%). Neither standard therapy nor consensus for the management of...

  • Article
  • Open Access
29 Citations
5,272 Views
14 Pages

Antimicrobial Resistance Genes and Diversity of Clones among Faecal ESBL-Producing Escherichia coli Isolated from Healthy and Sick Dogs Living in Portugal

  • Isabel Carvalho,
  • Rita Cunha,
  • Carla Martins,
  • Sandra Martínez-Álvarez,
  • Nadia Safia Chenouf,
  • Paulo Pimenta,
  • Ana Raquel Pereira,
  • Sónia Ramos,
  • Madjid Sadi and
  • Ângela Martins
  • + 8 authors

The purpose of this study was to analyse the prevalence and genetic characteristics of ESBL and acquired-AmpC (qAmpC)-producing Escherichia coli isolates from healthy and sick dogs in Portugal. Three hundred and sixty-one faecal samples from sick and...

  • Article
  • Open Access
29 Citations
5,657 Views
16 Pages

Metagenomics-Based Analysis of the Age-Related Cumulative Effect of Antibiotic Resistance Genes in Gut Microbiota

  • Lei Wu,
  • Xinqiang Xie,
  • Ying Li,
  • Tingting Liang,
  • Haojie Zhong,
  • Jun Ma,
  • Lingshuang Yang,
  • Juan Yang,
  • Longyan Li and
  • Yu Xi
  • + 5 authors

Antibiotic resistance in bacteria has become a major global health problem. One of the main reservoirs of antibiotic resistance genes is the human gut microbiota. To characterise these genes, a metagenomic approach was used. In this study, a comprehe...

  • Article
  • Open Access
31 Citations
4,422 Views
9 Pages

High Prevalence of Multidrug-Resistant Klebsiella pneumoniae in a Tertiary Care Hospital in Ethiopia

  • Tewachew Awoke,
  • Brhanu Teka,
  • Aminu Seman,
  • Shemse Sebre,
  • Biruk Yeshitela,
  • Abraham Aseffa,
  • Adane Mihret and
  • Tamrat Abebe

Klebsiella pneumoniae poses an urgent public health threat, causing nosocomial outbreaks in different continents. It has been observed to develop resistance to antimicrobials more easily than most bacteria. These days, multidrug-resistant strains are...

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Antibiotics - ISSN 2079-6382