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Journal of Functional Biomaterials, Volume 16, Issue 9

September 2025 - 51 articles

Cover Story: This study reports the development of a novel injectable calcium phosphate cement (CPC) co-loaded with gentamicin and vancomycin for the localized treatment of polymicrobial bone infections. The dual incorporation of antibiotics preserved the cement’s handling properties, maintained high porosity, and ensured biocompatibility with human osteoblasts. A rapid burst release followed by sustained antibiotic delivery provided broad-spectrum antibacterial effects against both Gram-positive and Gram-negative pathogens, including resistant strains. Importantly, the combination of gentamicin and vancomycin demonstrated superior antibiofilm activity compared to single-antibiotic formulations, highlighting this CPC as a promising strategy for managing osteomyelitis. View this paper
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Articles (51)

  • Article
  • Open Access
3,439 Views
10 Pages

Comparative Evaluation of Shear Bond Strength Between Monolithic Zirconia and Three Different Core Build-Up Materials

  • Ayben Şentürk,
  • Bora Akat,
  • Fehmi Gönüldaş,
  • Onur Alp Halaçlı,
  • Selin Kartal and
  • Mehmet Ali Kılıçarslan

21 September 2025

This in vitro study aimed to evaluate and compare the shear bond strength (SBS) between monolithic zirconia (MZ) and different core build-up materials. Sixty cylindrical MZ specimens were fabricated and divided into three groups (n = 20) based on the...

  • Review
  • Open Access
4 Citations
2,016 Views
32 Pages

19 September 2025

Bacterial contamination and the escalating crisis of antibiotic resistance represent pressing global public health threats, with approximately 4.95 million deaths linked to antimicrobial resistance (AMR) in 2019 and projections estimating up to 10 mi...

  • Review
  • Open Access
1 Citations
2,184 Views
18 Pages

Clinical Efficacy of Clear Aligners in Class II Malocclusion: From Pediatric to Adult Cases–A Narrative Review

  • Gianna Dipalma,
  • Grazia Marinelli,
  • Francesco Inchingolo,
  • Marialuisa Longo,
  • Maral Di Giulio Cesare,
  • Sharon Di Serio,
  • Andrea Palermo,
  • Massimo Del Fabbro,
  • Alessio Danilo Inchingolo and
  • Angelo Michele Inchingolo

19 September 2025

Background: Class II malocclusion is one of the most common and challenging orthodontic problems, often requiring complex, lengthy treatment and sometimes involving extractions or surgery. While conventional fixed appliances have been the gold standa...

  • Review
  • Open Access
1,409 Views
36 Pages

Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K

  • Andreea Crintea,
  • Camelia Munteanu,
  • Tamás Ilyés,
  • Ciprian N. Silaghi and
  • Alexandra M. Crăciun

19 September 2025

Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile p...

  • Review
  • Open Access
1,660 Views
18 Pages

Bionanomaterials or Nanobiomaterials: Differences in Definitions and Applications

  • Bogdan Walkowiak,
  • Małgorzata Siatkowska and
  • Piotr Komorowski

18 September 2025

Since the turn of the century, we have witnessed an extremely intensive development of biotechnology and nanotechnology, which, in terms of intensity can only be compared to the development of information technology and the resulting emergence of art...

  • Article
  • Open Access
2 Citations
1,172 Views
22 Pages

Data-Driven Design and Additive Manufacturing of Patient-Specific Lattice Titanium Scaffolds for Mandibular Bone Reconstruction

  • Nail Beisekenov,
  • Bagdat Azamatov,
  • Marzhan Sadenova,
  • Dmitriy Dogadkin,
  • Daniyar Kaliyev,
  • Sergey Rudenko and
  • Boris Syrnev

18 September 2025

The reconstruction of segmental bone defects requires patient-specific scaffolds that combine mechanical safety, biological functionality, and rapid manufacturing. We converted CT-derived mandibular geometry into a functionally graded Ti-6Al-4V latti...

  • Review
  • Open Access
1,560 Views
42 Pages

Integrating Additive and Traditional Manufacturing for Multiscale Bone Tissue Engineering Scaffolds

  • Yixuan Zhu,
  • Haotian Gao,
  • Qingchen Qiao,
  • Yafei Yuan,
  • Dongyu Fang,
  • Yuxing Bai and
  • Qingsong Jiang

16 September 2025

Additive manufacturing (AM) has emerged as a cutting-edge technology for fabricating biomimetic scaffolds with controllable architectures and compositional diversity, showing great promise in the fields of bone tissue engineering (BTE) and regenerati...

  • Article
  • Open Access
721 Views
16 Pages

Original Locking Rod System Designed for Diaphyseal Fractures of Long Bones

  • Liviu-Coriolan Misca,
  • Cristian Constantin Croicu,
  • Adrian Emil Lazarescu,
  • Mihai-Alexandru Sandesc,
  • Jenel Marian Patrascu,
  • Sorin Florescu and
  • Jenel Marian Patrascu

15 September 2025

Introduction: Intramedullary nailing is widely used for long bone fractures. Traditional systems are reliable, but they present some complications regarding lack of modularity or possible growth plate damage. Methods: A novel locking rod–screw...

  • Article
  • Open Access
1 Citations
1,368 Views
13 Pages

15 September 2025

Biocompatibility evaluation of medical devices is essential for ensuring safety, with ISO 10993 series being the standard. However, these tests can be time-consuming and resource-intensive. This study assessed the early-stage biocompatibility of a co...

  • Article
  • Open Access
1,060 Views
16 Pages

14 September 2025

The development of high-performance sensing materials is critical for advancing bioelectronics. Conductive hydrogels, with their unique flexibility, are promising candidates for biomedical sensors. However, traditional conductive hydrogels often suff...

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J. Funct. Biomater. - ISSN 2079-4983