Journal of Functional Biomaterials, Volume 16, Issue 9

This in vitro study aimed to evaluate and compare the shear bond strength (SBS) between monolithic zirconia (MZ) and different core build-up materials. Sixty cylindrical MZ specimens were fabricated and divided into three groups (n = 20) based on the...

Bacterial contamination and the escalating crisis of antibiotic resistance represent pressing global public health threats, with approximately 4.95 million deaths linked to antimicrobial resistance (AMR) in 2019 and projections estimating up to 10 mi...

Background: Class II malocclusion is one of the most common and challenging orthodontic problems, often requiring complex, lengthy treatment and sometimes involving extractions or surgery. While conventional fixed appliances have been the gold standa...

Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile p...

Since the turn of the century, we have witnessed an extremely intensive development of biotechnology and nanotechnology, which, in terms of intensity can only be compared to the development of information technology and the resulting emergence of art...

The reconstruction of segmental bone defects requires patient-specific scaffolds that combine mechanical safety, biological functionality, and rapid manufacturing. We converted CT-derived mandibular geometry into a functionally graded Ti-6Al-4V latti...

Additive manufacturing (AM) has emerged as a cutting-edge technology for fabricating biomimetic scaffolds with controllable architectures and compositional diversity, showing great promise in the fields of bone tissue engineering (BTE) and regenerati...

Introduction: Intramedullary nailing is widely used for long bone fractures. Traditional systems are reliable, but they present some complications regarding lack of modularity or possible growth plate damage. Methods: A novel locking rod–screw...

Biocompatibility evaluation of medical devices is essential for ensuring safety, with ISO 10993 series being the standard. However, these tests can be time-consuming and resource-intensive. This study assessed the early-stage biocompatibility of a co...

The development of high-performance sensing materials is critical for advancing bioelectronics. Conductive hydrogels, with their unique flexibility, are promising candidates for biomedical sensors. However, traditional conductive hydrogels often suff...

Although ridge preservation procedures have been shown to prevent post-extraction bone loss, the effectiveness of using a flap or flapless surgical approach remains unclear. The aim of the study was to compare the mentioned above alveolar ridge prese...

Mg alloys hold promise for biodegradable gastrointestinal implants, but most evaluations rely on simplified media like Hank’s solution, which lacks organic components and fails to replicate the acidic-to-alkaline transition of intestinal fluid, riski...

In this study, the properties of electrophoretically deposited (EPD) coatings on orthodontic implants made from Ti-6Al-4V alloy were evaluated during simulated implantation trials on animal bones. Three types of chitosan-based coatings were prepared...

Implant abutments serve as the critical interface between dental implants and prosthodontic restorations, playing a central role in the functional and aesthetic success of implant-supported rehabilitations. With the development of CAD/CAM technologie...

Background: The growing demand for effective methods of bone tissue regeneration highlights the relevance of studying modern bone substitutes and their applications in regenerative medicine. The aim of this work was to conduct a comprehensive analysi...

Protein adsorption on orthopedic biomaterials during the initial intraoperative contact critically influences biological responses and osseointegration. Osteoconductive grafts such as β-tricalcium phosphate (β-TCP) and poly (ε-capro...

Osteoarthritis (OA), the most common joint disease, is marked by cartilage degradation and chronic inflammation. While 45S5-bioactive glass (45S5-BG) is well-established in bone regeneration and has been suggested to exert immunomodulatory effects, i...

Polysaccharides have emerged as promising biomaterials for 3D bioprinting due to their inherent biocompatibility, biodegradability, and structural diversity. However, their limited mechanical strength, insufficient bioactivity, and suboptimal printab...

In the present study, we evaluated the usefulness of a porous sintered calcium carbonate body with CaSiO₃ by comparing its osteogenic capacity with that of calcium carbonate without CaSiO₃ and that of β-tricalcium phosphate (TP). A cranial defec...

Dental plaque, if not regularly removed through proper oral hygiene, can lead to tooth decay, gingivitis, and more severe periodontal disease. Effective plaque removal is essential in preventing gingivitis, the precursor to periodontitis. Propolis, a...

Aim: To compare the fracture resistance of teeth with varying degrees of residual coronal dentine after restoration using two fibre-reinforced composite core materials. Materials and Methods: Seventy extracted human lower premolars were divided into...

This study investigates the thermal properties and sterilization efficacy of polylactic acid (PLA) components fabricated via fused deposition modeling (FDM), focusing on PLA’s compatibility with autoclave sterilization protocols. While PLA is e...

Finite element analysis is commonly used to evaluate implant biomechanics, yet limited data exist on arch form and trabecular-surfaced implants. This study aimed to investigate the biomechanical impact of a designed trabecular surface compared with a...

Background: Micro- and nanoplastics (MNPs) have emerged as increasing environmental and public health concerns. Dentistry contributes to this exposure through polymer-based materials and personal oral care products. This review summarizes the current...

Background: To evaluate the fracture resistance of 3D-printed 3-unit fixed dental prostheses (FDPs) made from tetragonal zirconia polycrystal (3Y-TZP). Methods: Based on a maxillary typodont model with a missing first molar and neighboring teeth with...

Gram-positive bacteria are responsible for initiating dental caries. In this process, lipoteichoic acid (LTA), which is expressed on Gram-positive bacteria cell walls, binds to the dental pulp cells, triggering an immune response, followed by inflamm...

This study aimed to evaluate how acidic and alkaline staining solutions affect the optical properties (mean color change, ΔE*), geometric characteristics (surface roughness, Ra), and bacterial adhesion of zirconia Ceramill Zolid PS computer-aid...

3D bioprinting has emerged as a key tool in tissue engineering by facilitating the creation of customized scaffolds with properties tailored to specific needs. Among the design parameters, porosity stands out as a determining factor, as it directly i...

Scaffold architecture is a key determinant of cell behavior and tissue regeneration in bone tissue engineering, yet the influence of pore size under dynamic culture conditions remains incompletely understood. This study aimed to evaluate the effects...

Surgical management of condylar process fractures is associated with postoperative complications, the most common being transient facial nerve palsy. Less frequent but noteworthy is the development of salivary fistulas, which, although rare, constitu...

Although caries is declining in industrialized countries, early childhood caries and molar–incisor hypomineralization (MIH) remain clinically relevant. To meet the demand for effective and well-tolerated preventive strategies, hydroxyapatite (H...

Surface roughness and morphology, along with surface chemistry, are key features for improving ingrowth behavior and combating peri-implantitis after the insertion of dental implants. Using femtosecond laser texturing, this study aims to control both...

Directed cell migration is crucial for numerous biological processes, including tissue regeneration and cancer metastasis. However, conventional symmetrical micropatterns typically result in bidirectional cell migration guidance instead of unidirecti...

Implantable biomaterials are widely used in modern medicine, especially in orthopaedics, cardiovascular surgery, dentistry, and plastic and reconstructive surgery. The issue of the interaction of implants with body tissues and the risk of infection a...

Background: Bovine bone-derived xenografts are widely used in regenerative dental procedures due to their osteoconductive properties and volumetric stability. However, their long-term behavior and biological integration remain a subject of debate. Th...

This study presents the development of a degradable and biocompatible calcium phosphate cement (CPC) co-loaded with gentamicin (1.25 wt%) and vancomycin (4.25 wt%) for the local treatment of polymicrobial bone infections. The antibiotics were incorpo...

Bioactive resin cements are gaining popularity for their clinical benefits, but concerns remain regarding their color stability. This study evaluated the color change (ΔE₀₀) and whiteness change (ΔWI_D) in bioactive resin cements and how t...

The growing challenge of biofilm-associated infections in dentistry necessitates advanced solutions. This review highlights the potential of smart bioactive and antibacterial materials—bioactive glass ceramics (BGCs), silver nanoparticle (AgNP)...

Bone is a calcified tissue composed of 60% inorganic compounds, 30% organic compounds, and 10% water. Bone exhibits an intrinsic regenerative capacity, enabling it to heal after fractures or adapt during growth. However, in cases of severe injury or...

Acne vulgaris is a chronic disease that occurs in the pilosebaceous units and ranks eighth in the global prevalence of all diseases. In its severe forms such as pustules, cysts, and nodules, acne can lead to permanent scarring and post-inflammatory h...

Cardiovascular disease is a leading cause of global mortality. Percutaneous coronary intervention, which involves the placement of stents to restore blood flow in narrowed arteries, is a widely used treatment. However, traditional stents, such as bar...

Periodontal therapy remains a complex task in dentistry as current methodologies often tend to induce tissue repair rather than regeneration. Caffeine is an alkaloid found in multiple natural sources, which has been reported to have multiple benefici...

This review article provides a comprehensive evaluation of Infuse^® and InductOs^®, two ground-breaking recombinant human Bone Morphogenetic Protein-2 (rhBMP-2)-based bone graft products, focusing on their tissue-level regenerative responses, c...

Implant treatment in the aesthetic regions of the jaw often requires hard and soft tissue augmentation to ensure optimal prosthetic outcomes. Radiological evaluation with cone-beam computed tomography (CBCT) and visual inspection of intraoral photogr...

The exposure of endothelial cells to high glucose concentrations promotes angiogenesis. The present study investigated whether this pro-angiogenic effect of glucose is suitable to improve the capability of nanofat to vascularize implanted dermal subs...

This scoping review aimed to systematically map the literature on digital workflows for the design and fabrication of customized bone grafts in oral and maxillofacial surgery. The review focused on the integration of cone-beam computed tomography (CB...

This in vitro study evaluated the internal surface trueness and the marginal and internal fit of interim crowns fabricated from intraoral scanner (IOS; i500, MEDIT, Seoul, Republic of Korea) data, considering variations in subgingival finish line dep...

The objective of this study was to provide a comprehensive review of the types, properties, and potential applications of nanomaterials in phototherapy for caries prevention. This scoping review follows the Preferred Reporting Items for Systematic re...

Light attenuation and excess handling of light-cured luting agents create problems in bonding veneer restorations. The aim of the present study was to assess the curing capacity of light-cured veneer luting agents (VLA) [Choice 2 (CH2), G-Cem Veneer...

During the investigation, the effect of screw tightening torque on the potential loosening of screws under load was examined in the case of custom-made subperiosteal implants. The study focused on the connection screws between the implant components,...