2026 March - 52 articles
Modern bioimplants increasingly depend on surface-engineered functionality to elicit adaptive biological responses. One promising strategy involves the electrodeposition of bioresponsive elements such as magnesium (Mg), which plays a critical role in...
In computer-aided design/computer-aided manufacturing (CAD/CAM) restorations for severely damaged teeth, the cavity floor or proximal margins may be elevated with composite resin to improve adhesion. This in vitro study investigated how different sur...
Large bone defects resulting from trauma, tumor resection, infection, or degenerative diseases pose a major clinical challenge in orthopedic surgery and regenerative medicine. Despite advances in biomaterials and surgical techniques, successful outco...
Skeletal muscle myopathy remains a significant cause of disability with limited treatment strategies. Advancements in tissue engineering have led to the development of borophosphate bioactive glasses (BPBGs) capable of enhancing skeletal muscle struc...
Hyaluronic acid (HA) is a biologically active glycosaminoglycan with recognized roles in wound healing and inflammation modulation, and its adjunctive use in dental and periodontal therapy has gained interest, particularly in medically compromised pa...
Mesoporous bioactive glass (MBG) has been extensively studied in bone regeneration due to its excellent bioactivity and osteoconductive properties. Here, we prepared amino-modified MBG (MBG-NH2) adsorbed osteopontin (OPN) to form MBG-NH2/OPN composit...
Green synthesis of nanoparticles has become one of the most popular research areas in recent decades due to its environmentally friendly nature and the minimization of harmful chemical by-products. This review focuses on the mechanism of palladium na...
Transparent heaters intended for skin-contacting applications must simultaneously satisfy optical transparency, mechanical compliance, thermal uniformity, and operational safety under biologically relevant temperature ranges. Here, we evaluate the ap...
Background: Oroantral communication (OAC) is a frequent complication after the extraction of maxillary posterior teeth and requires immediate closure to prevent sinus pathology and long-term functional impairment. Objectives: This study aimed to comp...
Low-density cancellous bone results in reduced trabecular support and may increase crestal cortical strain around implants. Osseodensification (OD) compacts trabecular bone and may create a peri-osteotomy densified zone, but its strain-level effects...
Despite advances in periodontal regenerative therapies, consistent tissue regeneration remains challenging, with cells playing an essential role in successful repair. Therefore, this study tested different dental bone substitutes embedded in the chor...
Vital pulp therapy comprises a group of procedures whose use in the primary dentition is increasingly supported in pediatric dentistry. The clinical management of pediatric patients requires biomaterials that provide precision, ease of handling, and...
Biodegradable zinc (Zn) has attracted increasing interest as a material for temporary implants, primarily due to its moderate degradation kinetics. In recent years, additive manufacturing of Zn alloys using the laser powder bed fusion method (L-PBF)...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is characterized by exposed necrotic bone that often progresses with increasing pain and impaired quality of life. Zoledronate, the most potent and widely used bisphosphonate, has been strongly...
This study investigates and compares properties of various P-type Triply Periodic Minimal Surface (TPMS) porous structures for bone scaffold design. At first, six cases of homogeneous single/dual-layer structures, axial single/dual-layer gradient str...
Background: Interbody spinal fusion is a common surgical treatment for degenerative, traumatic, and deformity-related spinal pathologies. Despite advances in cage geometry and fixation strategies that improve alignment and early stability, reliable f...
Chronic osteomyelitis and infected bone defects are driven by recurrent infection, biofilm persistence, and dysregulated inflammation, but conventional “eradicate bacteria and fill the defect” approaches often fail to restore a regenerati...
Background: The microtensile bond strength (μTBS) test is the gold standard for evaluating adhesive performance in restorative dentistry. However, the conventional non-trimming technique—referred to in this study as the monoblock sectioning...
Intervertebral disk pathology, including disk herniation and degeneration, is a major contributor to chronic low back pain, and when conservative treatment fails, surgical management often involves discectomy-based procedures that leave residual annu...
Dental resin composites are routinely exposed to chemically aggressive beverages that may compromise long-term functional performance. This study investigated the structure–property–tribology relationships of four restorative composites (...
Stem cell heterogeneity represents a critical yet underexplored variable in laser-assisted regenerative strategies. While photobiomodulation has been shown to influence mesenchymal stem cell (MSC) behavior, it remains unclear whether stem cell matura...
In order to provide clinically significant evidence on the long-term functional performance of CAD/CAM provisional materials, especially 3D-printed and milled resins, accurate tribologically in vitro wear tests that integrate wear parameters and surf...
Oral mucositis frequently develops during radiotherapy or chemotherapy for head and neck cancer and is characterized by severe pain and impaired eating and speech. It was previously demonstrated that freeze-dried hyaluronic acid (HA) sheets effective...
Current in vitro tissue models struggle to recapitulate the structural, vascular, and mechanical complexity of human tissues, limiting their physiological relevance for disease modelling and preclinical testing. Self-organising three-dimensional cult...
This paper presents the results of an experimental study on the effects of magnetite nanoparticle (MNP) shape on magnetic resonance imaging (MRI) of triple-negative breast cancer (TNBC) xenograft tissues. T2-weighted MRI scans using spherical shaped...
Surface damage occurring during surgery can compromise coating integrity, leaving exposed areas susceptible to bacterial colonization. However, the impact of partial coating loss on antibacterial performance has not yet been investigated. In this wor...
Zirconium is a widely used material in the field of dentistry, employed for implants and their components as well as for the creation of crowns and veneers. Given that its biocompatibility has been studied and demonstrated in various fields of applic...
This study compared the physicochemical and biological properties of Bio-C Repair (BR), a new putty-type calcium silicate-based material, with ProRoot MTA (P) and Super-Bond (SB). Discs of the three materials were prepared. Human periodontal ligament...
Background: The clinical translation of natural nanomaterials and smart delivery systems in regenerative dentistry relies heavily on practitioner acceptance; however, end-user perspectives remain under-investigated. Objective: This study evaluated de...
The orthodontic landscape is currently witnessing a significant technological evolution with the emergence of direct 3D-printed aligners (DPAs), which promise to close the digital workflow loop by eliminating the geometric limitations and solid model...
Articular cartilage is a highly specialized connective tissue essential for joint function, providing load-bearing capacity, shock absorption, and near-frictionless motion. Due to its avascular nature, articular cartilage has a limited intrinsic heal...
Background/Objectives: This study evaluated autologous platelet concentrates (APCs), including advanced platelet-rich fibrin (A-PRF+) and concentrated growth factors (CGFs), as biologically active matrices, and photobiomodulation (PBM) as a biophysic...
Photobiomodulation (PBM) has shown promising potential to enhance bone regeneration; however, its optimal delivery parameters and interactions with osteoconductive scaffolds remain insufficiently defined. This preclinical study is the first to incorp...
Colorectal resection and subsequent anastomosis are the standard curative procedures for a variety of colorectal pathologies. However, anastomotic leakage (AL) is an early and frequent complication that can have life-threatening outcomes. The study a...
Background: Calcium silicate-based materials are widely used in retrograde endodontic treatment due to their bioactivity and favorable biological properties. The environmental conditions during setting and the time-dependent release of soluble compon...
Background: This study aimed to investigate the biomechanical behavior of conservative inlay restorations fabricated from different CAD/CAM materials by combining experimental flexural strength testing with finite element analysis. Methods: Five CAD/...
End-stage liver disease caused by advanced fibrosis and cirrhosis remains a major global burden, yet its treatment is limited by donor organ shortages. Bioengineered liver scaffolds offer a promising alternative, but their efficacy is often limited b...
The design of new medical devices in biomedical engineering often necessitates the control of microbial load at the point of application, making antibacterial action valuable for numerous applications in the biomedical field. Nanotechnology products,...
Bone regeneration focuses on the creation of functional tissue to repair bone defects. Creating a biodegradable scaffold hydrogel that combines a hemostatic agent with bioactive ceramics can afford the biological and mechanical benefits of both compo...
Achilles tendon rupture often leads to poor functional recovery due to limited self-healing, with mitochondrial dysfunction in tendon stromal cells (TSCs) being a key factor in disease progression. Here, we developed adipose-derived stromal cell (ADS...
Background: Intermaxillary elastics are widely used in orthodontics to deliver controlled forces for malocclusion correction, aiding in the correction of anteroposterior, vertical, or transverse problems. Despite their clinical relevance, comprehensi...
Synthetic biomaterials used as bone graft extenders (BGE) in spinal fusion surgery can supplement but do not replace autologous bone. This pilot study evaluated a calcium sulfate/hydroxyapatite (CaS/HA) material as an antibiotic-eluting BGE and a car...
Type II collagen (CII), the major structural protein in the cartilage extracellular matrix, is a promising biomaterial for scaffold design in cartilage tissue engineering. In this study, high-purity CII was successfully extracted from bovine cartilag...
Rapid vascularization is essential for bone regeneration in oral and maxillofacial surgery. This systematic review synthesised in vivo evidence on 3D-printed composite scaffolds in rodent critical-size calvarial defects quantified by Microfil perfusi...
Background/Objectives: This study evaluated the influence of key biomechanical parameters—orthodontic force magnitude, loading direction, and insertion depth—on stress and strain distribution in orthodontic mini-implants using three-dimen...
Low-intensity pulsed ultrasound (LIPUS) has emerged as a versatile, non-invasive physical modality with growing potential in regenerative medicine and neural repair. Advances in ultrasound physics and biomedical engineering have enabled precise spati...
This study compared the mechanical and thermal properties of new and retrieved multizone rhodium-coated superelastic nickel-titanium (NiTi) archwires across anterior and posterior segments. Using three-point bending tests, Scanning Electron Microscop...
The success of titanium dental implants rely on osseointegration, influenced by surface properties and early immune responses. While sandblasted and acid-etched (SLA) titanium surfaces have shown clinical success, macrophage-mediated immune responses...
The success of orthodontic therapy depends on the effective, continuous application of forces to teeth. Therefore, an essential element of the treatment is the adhesion between the bracket and enamel. The purpose of this study was to evaluate the inf...
Additive manufacturing is now an integral part of digital prosthodontic workflows, and although stereolithography (SLA) is widely used for denture base fabrication, the dimensional accuracy of printed dentures remains highly dependent on manufacturin...
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