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Journal of Functional Biomaterials, Volume 16, Issue 9

September 2025 - 51 articles

Cover Story: This study reports the development of a novel injectable calcium phosphate cement (CPC) co-loaded with gentamicin and vancomycin for the localized treatment of polymicrobial bone infections. The dual incorporation of antibiotics preserved the cement’s handling properties, maintained high porosity, and ensured biocompatibility with human osteoblasts. A rapid burst release followed by sustained antibiotic delivery provided broad-spectrum antibacterial effects against both Gram-positive and Gram-negative pathogens, including resistant strains. Importantly, the combination of gentamicin and vancomycin demonstrated superior antibiofilm activity compared to single-antibiotic formulations, highlighting this CPC as a promising strategy for managing osteomyelitis. View this paper
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Articles (51)

  • Article
  • Open Access
872 Views
18 Pages

Clinical and Radiological Evaluation of Flap and Flapless Procedures with Biomaterials in Alveolar Ridge Preservation

  • Ewa Dolińska,
  • Ewa Duraj,
  • Marcin Bernaczyk,
  • Magdalena Sulewska and
  • Małgorzata Pietruska

14 September 2025

Although ridge preservation procedures have been shown to prevent post-extraction bone loss, the effectiveness of using a flap or flapless surgical approach remains unclear. The aim of the study was to compare the mentioned above alveolar ridge prese...

  • Article
  • Open Access
1 Citations
714 Views
19 Pages

Antibacterial Activity of a Trace-Cu-Modified Mg Alloy in Simulated Intestinal Fluid

  • Baiyun Zhong,
  • Zemeng Wei,
  • Yi Yao,
  • Lixun Jiang,
  • Manli Zhou,
  • Jinping Li,
  • Weidong Liu,
  • Xin Li and
  • Ming-Chun Zhao

12 September 2025

Mg alloys hold promise for biodegradable gastrointestinal implants, but most evaluations rely on simplified media like Hank’s solution, which lacks organic components and fails to replicate the acidic-to-alkaline transition of intestinal fluid, riski...

  • Article
  • Open Access
910 Views
27 Pages

Electrophoretic Coatings for Orthodontic Implants: Evaluation of Surface Properties, Adhesion, and Antibacterial Activity in Simulated Implantation Trials

  • Maria Biegun-Żurowska,
  • Karolina Klesiewicz,
  • Katarzyna Matysiak,
  • Marcin Gajek,
  • Alicja Rapacz-Kmita and
  • Magdalena Ziąbka

12 September 2025

In this study, the properties of electrophoretically deposited (EPD) coatings on orthodontic implants made from Ti-6Al-4V alloy were evaluated during simulated implantation trials on animal bones. Three types of chitosan-based coatings were prepared...

  • Review
  • Open Access
1,466 Views
12 Pages

Influence of Design Parameters on Implant Abutment Performance: A Scoping Review

  • Vladimir Prpic,
  • Petar Kosec,
  • Stanko Skec and
  • Amir Catic

11 September 2025

Implant abutments serve as the critical interface between dental implants and prosthodontic restorations, playing a central role in the functional and aesthetic success of implant-supported rehabilitations. With the development of CAD/CAM technologie...

  • Systematic Review
  • Open Access
2 Citations
2,539 Views
48 Pages

Types of Bone Substitutes and Their Application in Regenerative Medicine: A Systematic Review

  • Nikoleta Ivanova,
  • Stoyan Ivanov,
  • Stefan Peev and
  • Tsanka Dikova

9 September 2025

Background: The growing demand for effective methods of bone tissue regeneration highlights the relevance of studying modern bone substitutes and their applications in regenerative medicine. The aim of this work was to conduct a comprehensive analysi...

  • Article
  • Open Access
1 Citations
973 Views
16 Pages

Intraoperative Biologization of β-TCP and PCL-TCP by Autologous Proteins

  • Andrea Sowislok,
  • Gerrit Gruber,
  • Farnusch Kaschani,
  • Markus Kaiser,
  • Eleftherios Papaeleftheriou and
  • Marcus Jäger

9 September 2025

Protein adsorption on orthopedic biomaterials during the initial intraoperative contact critically influences biological responses and osseointegration. Osteoconductive grafts such as β-tricalcium phosphate (β-TCP) and poly (ε-capro...

  • Article
  • Open Access
1,079 Views
17 Pages

Impact of 45S5-Bioactive Glass on Chondrocytes in Knee Osteoarthritis—In Vitro Study Exploring Cellular Responses

  • Max Marinescu,
  • Sébastien Hagmann,
  • Jörg Fellenberg,
  • Elena Tripel,
  • Simone Gantz,
  • Ravikumar Mayakrishnan,
  • Aldo R. Boccaccini,
  • Tobias Renkawitz,
  • Babak Moradi and
  • Fabian Westhauser
  • + 1 author

9 September 2025

Osteoarthritis (OA), the most common joint disease, is marked by cartilage degradation and chronic inflammation. While 45S5-bioactive glass (45S5-BG) is well-established in bone regeneration and has been suggested to exert immunomodulatory effects, i...

  • Review
  • Open Access
1,250 Views
28 Pages

Modified Polysaccharides: Potential Biomaterials for Bioprinting

  • Tao Jiang,
  • Yun Yang,
  • Zening Lin,
  • Yang Hong and
  • Zirong Luo

9 September 2025

Polysaccharides have emerged as promising biomaterials for 3D bioprinting due to their inherent biocompatibility, biodegradability, and structural diversity. However, their limited mechanical strength, insufficient bioactivity, and suboptimal printab...

  • Article
  • Open Access
933 Views
13 Pages

Comparative Evaluation of the Bone Regenerative Potential of a Novel Calcium Silicate-Modified Calcium Carbonate Graft Material: Histological and Micro-Computed Tomography Assessment Using a Rat Calvarial Defect Model

  • Masataka Nakayama,
  • Yu Kataoka,
  • Naoki Kitamura,
  • Chie Watanabe,
  • Satoko Kujiraoka,
  • Kikue Yamaguchi,
  • Yuma Seki,
  • Toshitake Furusawa,
  • Hidero Unuma and
  • Motohiro Munakata

9 September 2025

In the present study, we evaluated the usefulness of a porous sintered calcium carbonate body with CaSiO3 by comparing its osteogenic capacity with that of calcium carbonate without CaSiO3 and that of β-tricalcium phosphate (TP). A cranial defec...

  • Systematic Review
  • Open Access
1 Citations
3,304 Views
22 Pages

Propolis as a Natural Remedy in Reducing Dental Plaque and Gingival Inflammation: A Systematic Review and Meta-Analysis

  • Magdalena Sycińska-Dziarnowska,
  • Liliana Szyszka-Sommerfeld,
  • Monika Bugajska,
  • Magdalena Ziąbka,
  • Izabela Szućko-Kociuba,
  • Gianrico Spagnuolo,
  • Krzysztof Woźniak and
  • Hyo-Sang Park

8 September 2025

Dental plaque, if not regularly removed through proper oral hygiene, can lead to tooth decay, gingivitis, and more severe periodontal disease. Effective plaque removal is essential in preventing gingivitis, the precursor to periodontitis. Propolis, a...

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J. Funct. Biomater. - ISSN 2079-4983