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Journal of Clinical Medicine, Volume 8, Issue 10

October 2019 - 255 articles

Cover Story: We investigated treatment with a virus-derived immune modulating serine protease inhibitor (SERPIN), Serp-1, which inhibits thrombolytic proteases and inflammation, in a mouse excisional wound model. A chitosan-collagen hydrogel was also tested for Serp-1 delivery. Serp-1 treatment significantly accelerated wound healing, but was blocked by urokinase-type plasminogen activator (uPAR) antibody. Repeated dosing at a lower concentration was more effective than single high-dose serpin. A single application of Serp-1-loaded chitosan-collagen hydrogel was as effective as repeated aqueous Serp-1 dosing. Serp-1 treatment of wounds increased arginase-1-expressing M2-polarized macrophage counts and periwound angiogenesis in the wound bed. Serp-1 has potential as a safe and effective immune modulating treatment that targets thrombolytic proteases, accelerating healing and reducing scar in deep cutaneous wounds. View this paper.
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Articles (255)

  • Article
  • Open Access
23 Citations
3,573 Views
10 Pages

A TUG Value Longer Than 11 s Predicts Fall Risk at 6-Month in Individuals with COPD

  • Vivien Reynaud,
  • Daniela Muti,
  • Bruno Pereira,
  • Annick Greil,
  • Denis Caillaud,
  • Ruddy Richard,
  • Emmanuel Coudeyre and
  • Frédéric Costes

22 October 2019

Risk of a fall is increased in individuals with chronic obstructive pulmonary disease (COPD), and is usually evaluated using the Berg Balance Scale (BBS), but this is difficult to perform in everyday clinical practice. We aimed to prospectively predi...

  • Review
  • Open Access
65 Citations
9,445 Views
13 Pages

Oral–Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?

  • Lorenzo Drago,
  • Gian Vincenzo Zuccotti,
  • Carlo Luca Romanò,
  • Karan Goswami,
  • Jorge Hugo Villafañe,
  • Roberto Mattina and
  • Javad Parvizi

22 October 2019

The gut microbiome appears to be a significant contributor to musculoskeletal health and disease. Recently, it has been found that oral microbiota are involved in arthritis pathogenesis. Microbiome composition and its functional implications have bee...

  • Review
  • Open Access
49 Citations
20,598 Views
18 Pages

Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle

  • Olga Mediano,
  • Sofia Romero-Peralta,
  • Pilar Resano,
  • Irene Cano-Pumarega,
  • Manuel Sánchez-de-la-Torre,
  • María Castillo-García,
  • Ana Belén Martínez-Sánchez,
  • Ana Ortigado and
  • Francisco García-Río

22 October 2019

Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles in the context of an anatomic...

  • Article
  • Open Access
30 Citations
5,837 Views
15 Pages

Nosocomial Vs. Community-Acquired Infective Endocarditis in Spain: Location, Trends, Clinical Presentation, Etiology, and Survival in the 21st Century

  • Christian Ortega-Loubon,
  • María Fe Muñoz-Moreno,
  • Irene Andrés García,
  • Francisco Javier Álvarez,
  • Esther Gómez-Sánchez,
  • Juan Bustamante-Munguira,
  • Mario Lorenzo-López,
  • Álvaro Tamayo-Velasco,
  • Pablo Jorge-Monjas and
  • Salvador Resino
  • + 2 authors

22 October 2019

Major changes have occurred in the epidemiology and etiology of infective endocarditis (IE). Nevertheless, the differences between nosocomial infective endocarditis (NIE) and community-acquired infective endocarditis (CIE) have not been addressed in...

  • Article
  • Open Access
4 Citations
4,143 Views
16 Pages

Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR): A Comparison Study between Ironman Athletes, Age Matched Controls and A General Community Cohort

  • Mai Tran,
  • Agatha Kwon,
  • David Holt,
  • Rebecca Kierle,
  • Benjamin Fitzgerald,
  • Isabel Scalia,
  • William Scalia,
  • Geoffrey Holt and
  • Gregory Scalia

22 October 2019

Background: During exercise there is a proportionally lower rise in systemic and pulmonary pressures compared to cardiac output due to reduced vascular resistance. Invasive exercise data suggest that systemic vascular resistance reduces more than pul...

  • Review
  • Open Access
19 Citations
5,208 Views
17 Pages

22 October 2019

Objectives: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. Meth...

  • Article
  • Open Access
39 Citations
4,534 Views
14 Pages

SOX2 Expression Is an Independent Predictor of Oral Cancer Progression

  • Juan C. de Vicente,
  • Paula Donate-Pérez del Molino,
  • Juan P. Rodrigo,
  • Eva Allonca,
  • Francisco Hermida-Prado,
  • Rocío Granda-Díaz,
  • Tania Rodríguez Santamarta and
  • Juana M. García-Pedrero

21 October 2019

Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately pr...

  • Article
  • Open Access
54 Citations
6,725 Views
13 Pages

21 October 2019

Purpose: The effects of exergaming-based physical activity (PA) interventions on preschoolers’ health outcomes and cognition remain largely unexplored. Therefore, we conducted a randomized controlled trial to discern the effectiveness of a home...

  • Review
  • Open Access
37 Citations
15,829 Views
20 Pages

21 October 2019

Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (...

  • Review
  • Open Access
16 Citations
7,176 Views
17 Pages

Oral Anticoagulant Therapy—When Art Meets Science

  • Patricia Lorena Cîmpan,
  • Romeo Ioan Chira,
  • Mihaela Mocan,
  • Florin Petru Anton and
  • Anca Daniela Farcaş

21 October 2019

Anticoagulant treatment is extremely important and frequently encountered in the therapy of various cardiovascular diseases. Vitamin K antagonists (VKA) are in use for the prevention and treatment of arterial and venous thromboembolism, despite the i...

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J. Clin. Med. - ISSN 2077-0383