E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Application of Retinal and Optic Nerve Imaging in Clinical Medicine"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 15 August 2019

Special Issue Editor

Guest Editor
Dr. Rodolfo Mastropasqua

Department of Neuroscience, Università Politecnica delle Marche, Ancona, Italy
E-Mail
Interests: Retinal imaging; Vitreoretinal diseases; OCT angiography; Intraocular Lymphoma; Diabetic Retinopathy

Special Issue Information

Dear Colleagues,

On behalf of the Journal of Clinical Medicine Editorial Team, I am delighted to present a Special Issue on the topic of “Application of Retinal and Optic Nerve Imaging in Clinical Medicine”.

In the last decades, the role of imaging in ophthalmology has aroused increasing interest due to the advent of novel diagnostic tools that are aiming at an early diagnosis and a change in the approach of patient’s management. Such advances allow physicians of different medical subspecialities to start collaborations with ophthalmologists, to recognize and treat systemic diseases through concerted efforts.

This Special Issue aims at creating a multidisciplinary forum of discussion about the role of retinal and optic nerve imaging, its application in clinical medicine, and how clinical medicine can integrate ophthalmic investigations.

The accepted papers will describe new developments in these areas. This Special Issue accepts high-quality articles containing original research results and case reports, as well as review articles of exceptional merit.

Potential topics include, but are not limited to, the following keywords.

Dr. Rodolfo Mastropasqua
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Retinal Diseases
  • Eye Inherited Diseases
  • Uveitis
  • Glaucoma
  • Neurophthalmology
  • Optic Nerve Imaging
  • Retinal Imaging
  • Microbiology
  • Diabetes
  • Infectious Disease

Published Papers (2 papers)

View options order results:
result details:
Displaying articles 1-2
Export citation of selected articles as:

Research

Open AccessArticle
Optical Coherence Tomography Angiography Findings in Fabry Disease
J. Clin. Med. 2019, 8(4), 528; https://doi.org/10.3390/jcm8040528
Received: 11 March 2019 / Revised: 12 April 2019 / Accepted: 14 April 2019 / Published: 17 April 2019
PDF Full-text (853 KB) | HTML Full-text | XML Full-text
Abstract
Background: Fabry disease (FD) is a X-linked recessive lysosomal storage disorder characterized by altered biodegradation of glycosphingolipids. It is a multisystem pathology, also involving ophthalmological systems that show modifications of the vessel wall due to glycosphingolipid deposits. Optical coherence tomography angiography (OCT-A) allows [...] Read more.
Background: Fabry disease (FD) is a X-linked recessive lysosomal storage disorder characterized by altered biodegradation of glycosphingolipids. It is a multisystem pathology, also involving ophthalmological systems that show modifications of the vessel wall due to glycosphingolipid deposits. Optical coherence tomography angiography (OCT-A) allows for an objective analysis of retinal microvasculature alterations, evaluating retinal vessel density in macular region. Methods: A total of 54 FD patients (34 females, 20 males, mean age 44.1 ± 15.6 years) and 70 controls (36 females, 34 males, mean age 42.3 ± 15.6 years) were included in this study. We evaluated vessel density in different macular areas (whole image, fovea, and parafovea) of both the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP). Results: In the SCP there was a significantly lower vascular density in patients compared with controls in whole image (49.95 ± 5.17% vs. 51.99 ± 2.52%; p < 0.001), parafovea (52.01 ± 6.69% vs. 54.30 ± 2.61%; p = 0.002), and fovea (22.38 ± 9.01% vs. 29.31 ± 5.84%; p < 0.0001). In the DCP the vessel density was statistically increased in each macular area in patients compared with controls (54.82 ± 8.07% vs. 50.93 ± 5.46%; p = 0.005, 57.76 ± 7.26% vs. 53.59 ± 5.46%; p = 0.0001, and 39.75 ± 8.59% vs. 34.43 ± 8.68%; p < 0.0001 for whole image, parafovea, and fovea, respectively). Conclusion: OCT-A analysis showed that the macular vessel density was significantly reduced in the SCP and increased in the DCP in FD patients compared with controls. These findings, which might be a consequence of the alteration of vascular wall occurring in FD, support the hypothesis that the evaluation of early retinal microvascular network changes could be a useful tool in the clinical evaluation of the disease. Full article
(This article belongs to the Special Issue Application of Retinal and Optic Nerve Imaging in Clinical Medicine)
Figures

Figure 1

Open AccessArticle
Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR
J. Clin. Med. 2019, 8(4), 474; https://doi.org/10.3390/jcm8040474
Received: 6 March 2019 / Revised: 28 March 2019 / Accepted: 4 April 2019 / Published: 7 April 2019
PDF Full-text (941 KB) | HTML Full-text | XML Full-text
Abstract
Background: To investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution. Methods: Twenty-one eyes of 21 patients suffering from CCSC with monolateral foveal [...] Read more.
Background: To investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution. Methods: Twenty-one eyes of 21 patients suffering from CCSC with monolateral foveal SRF successfully treated with oral eplerenone were enrolled in this retrospective study (group 1). The fellow eyes (21 eyes; group 2), healthy or affected by CCSC, without foveal SRF were considered in the analysis. A control healthy group was enrolled as well (healthy controls; n = 21). Main outcome measures during follow-up included changes of best corrected visual acuity (BCVA, logMAR), central macular thickness (CMT; µm), SRF (µm), subfoveal choroidal thickness (SFCT; µm), superficial capillary plexus density (SCPD, %), deep capillary plexus density (DCPD, %), and choriocapillaris density (CCD, %) and percentage of eyes showing foveal SRF resolution at different time points. Results: Functional and anatomical parameters significantly improved during the study in group 1. BCVA increased significantly (p < 0.001), while CMT, SFCT, and SRF decreased significantly (p < 0.001; p < 0.001, and p = 0.037, respectively). SCPD, DCPD, and CCD did not show any statistically significant difference during follow-up. In 71.4% of eyes, resolution of SRF was observed within 60 days and in the remaining 28.6%, at 120 days. In fellow eyes, SFCT decreased significantly (p < 0.001), whilst all other parameters did not modify. Conclusions: Eplerenone treatment in chronic CSCR potentially improves recovery of retinal and choroidal morphology as well as visual acuity gain. A complete resolution of foveal SRF was observed in all eyes during a 4-month follow-up, with most eyes healing at 2 months. Full article
(This article belongs to the Special Issue Application of Retinal and Optic Nerve Imaging in Clinical Medicine)
Figures

Figure 1

J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top