New Aspects of Cancer Stem Cell Biology: Implications for Innovative Therapies
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (14 May 2020) | Viewed by 69713
Special Issue Editors
Interests: ovarian cancer; cancer stem cells; tumor microenvrironment; tumor angiogenesis; cell adhesion molecules
Special Issue Information
Dear Colleagues,
The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are broadly defined as a subpopulation of tumor cells that, besides sharing some functional features with normal stem cells (self-renewal, low cycling rate and differentiation capacity), are able to drive tumor initiation, to rebuild the heterogeneity of the original tumor, to evade the immune system and to escape conventional treatments such as chemo- and radiotherapy. In light of these properties, CSCs have been implicated in tumor metastasis and recurrence. Nevertheless, the biological characteristics of CSCs, their molecular profile, their contribution to cancer progression, and even their existence, remain matters of intense debate and controversy among tumor biologists. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells.
Independent of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.
Dr. Ugo Cavallaro
Dr. Marco Giordano
Guest Editors
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Keywords
- cancer stem cells
- tumor-initiating cells
- drug resistance
- novel therapies
- metastasis
- tumor recurrence
- biomarkers
- signaling pathways
- metabolism
- CSC-based models
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