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Special Issue "Energetic Metabolism Impairment in Brain Dysfunction"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editors

Guest Editor
Prof. Dr. Annamaria Cimini

Professor of Cell Biology and Neurobiology, Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy
Interests: brain development; neuronal maturation; neurodegenerative diseases; brain cancer
Guest Editor
Prof. Dr. Elisabetta Benedetti

Professor of Cell Biology, Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy
Interests: brain development; neuronal maturation; neurodegenerative diseases; brain cancer

Special Issue Information

Dear Colleagues,

Alterations in energetic metabolism and redox homeostasis are thought to be central components of neurodegeneration that result in the impairment of important homeostatic processes in neurons, such as protein quality control mechanisms, neurotransmitter release/metabolism, the axonal transport of vesicles, and cell survival. Importantly, both bioenergetics and redox homeostasis are coupled to neuro-glial energetic metabolism. Redox and metabolic homeostasis is carried out by a complex interaction between neurons, glia, and the extracellular microenvironment. Alterations of the neuronal environment and/or genetic mutations of key genes may result in different neurodegenerative conditions, i.e. Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. Moreover, energetic metabolism impairment may lead to neurotrophins depletion, resulting in the activation of death pathways and the downregulation of survival pathways.

In summary, the understanding of the complex mechanisms occurring during neurodegeneration, both as a consequence of the interaction of genetic background with the environment and as an alteration of neuron-glia crosstalk, may bring new insight into the complex scenarios of different neurodegenerative diseases and provide a basis for new therapeutic approaches.

Prof. Dr.  Annamaria Cimini
Prof. Dr. Elisabetta Benedetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Neurodegenerative diseases
  • Glucose metabolism
  • Lipid metabolism
  • Neurotrophins
  • Apoptosis
  • Mitochondria
  • Peroxisomes
  • Neurotransmitters

Published Papers

This special issue is now open for submission.
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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