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Special Issue "Treatment of Obstructive Sleep Apnea: State-of-the-Art and Future Directions"
Deadline for manuscript submissions: 31 December 2019.
Interests: obstructive sleep apnea; upper airway; control of breathing; intermittent hypoxia; animal model; obesity; metabolic syndrome; leptin; chemogenetics
Obstructive sleep apnea (OSA) is recurrent upper airway obstruction caused by a loss of upper airway muscle tone during sleep, which leads to intermittent hypoxia and sleep fragmentation. OSA is a common disorder affecting 25–30% of adult population and more than 50% of obese individuals. OSA leads to poor neurocognitive, cardiovascular, metabolic, and possibly even oncological outcomes, but OSA treatment remains a challenge. Continuous positive airway pressure (CPAP) is a highly efficacious treatment for OSA, but poor adherence severely limits its use. Mandibular advancement devices have better compliance, but are not as effective as CPAP. Hypoglossal nerve stimulation is a promising alternative in patients, who are unable to tolerate CPAP, but so far it has been effective only in a limited subset of patients. Until recently, there was no effective pharmacotherapy, but promising drug-candidates have been emerging over the last year.
For an upcoming Special Issue in the Journal of Clinical Medicine "Therapies for Obstructive Sleep Apnea", we invite investigators to contribute original research articles (including animal and human studies; clinical studies will be given priority), as well as review articles, that will stimulate continuing efforts to develop better therapies for OSA. Potential topics may include, but are not limited to, the following:
- Novel aspects of CPAP treatment and interventions to improve CPAP adherence;
- Oral appliances in OSA: state-of-the-art;
- Hypoglossal nerve stimulation: novel approaches;
- Emerging pharmacotherapy of OSA;
- Pre-clinical studies of novel therapeutics in OSA;
- Treatment of OSA in children.
Prof. Dr. Vsevolod Y. Polotsky
Dr. Mihaela Teodorescu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- obstructive sleep apnea
- oral appliance
- hypoglossal nerve