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Journal of Clinical Medicine, Volume 11, Issue 5

March-1 2022 - 317 articles

Cover Story: Paravalvular leak after mitral surgical replacement is frequent. Some of them, especially larger ones, can be clinically significant. Heart failure and hemolysis are the most prevalent clinical manifestations. Surgical reparation is considered the gold-standard therapy in current guidelines, but the percutaneous approach has emerged as an alternative. Transcatheter paravalvular leak closure has shown excellent results with a low rate of complications. Therefore, it is now considered the first option in selected patients in experienced centers. In this review, we summarize the clinical manifestations, diagnosis, procedural details, and results of transcatheter mitral paravalvular leak closure. View this paper 
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Articles (317)

  • Review
  • Open Access
7 Citations
9,038 Views
30 Pages

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

  • Silvia Massa,
  • Riccardo Pagliarello,
  • Francesca Paolini and
  • Aldo Venuti

7 March 2022

Human papillomavirus (HPV) still represents an important threat to health worldwide. Better therapy in terms of further improvement of outcomes and attenuation of related side-effects is desirable. The pharmaceutical industry has always targeted natu...

  • Article
  • Open Access
6 Citations
2,462 Views
11 Pages

Postoperative Complications and Swallowing Function after Jejunal and Skin Flap Reconstruction for Hypopharyngeal Carcinoma—A Multicenter Retrospective Study

  • Kunihiko Tokashiki,
  • Isaku Okamoto,
  • Takuro Okada,
  • Hiroki Sato,
  • Taku Yamashita,
  • Takashi Matsuki,
  • Takahito Kondo,
  • Chihiro Fushimi,
  • Tatsuo Masubuchi and
  • Kouki Miura
  • + 2 authors

7 March 2022

This study compared the incidence of perioperative complications and swallowing function between free jejunal flap reconstruction and cutaneous free tissue flap construction. We included 223 patients who underwent hypopharyngeal reconstruction using...

  • Article
  • Open Access
11 Citations
2,789 Views
7 Pages

Arrhythmias in COVID-19/SARS-CoV-2 Pneumonia Infection: Prevalence and Implication for Outcomes

  • Andrea Denegri,
  • Matteo Sola,
  • Marianna Morelli,
  • Francesco Farioli,
  • Alberto Tosetti,
  • Matteo D’Arienzo,
  • Fulvio Savorani,
  • Giuseppe Stefano Pezzuto,
  • Giuseppe Boriani and
  • Lukasz Szarpak
  • + 1 author

7 March 2022

Arrhythmias (ARs) are potential cardiovascular complication of COVID-19 but may also have a prognostic role. The aim of this study was to explore the prevalence and impact of cardiac ARs in hospitalized COVID-19 patients. All-comer patients admitted...

  • Article
  • Open Access
2 Citations
2,833 Views
11 Pages

Angiotensin Converting Enzyme Inhibitors versus Receptor Blockers in Patients with Ventricular Tachyarrhythmias

  • Tobias Schupp,
  • Michael Behnes,
  • Mohammad Abumayyaleh,
  • Kathrin Weidner,
  • Kambis Mashayekhi,
  • Thomas Bertsch and
  • Ibrahim Akin

7 March 2022

Data investigating the prognostic value of treatment with angiotensin converting enzyme inhibitors (ACEi) and receptor blockers (ARB) usually focusses on patients presenting with heart failure (HF) or acute myocardial infarction (AMI). However, by pr...

  • Article
  • Open Access
15 Citations
3,196 Views
12 Pages

The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction

  • Fu-Chun Chiu,
  • Chin-Feng Tsai,
  • Pang-Shuo Huang,
  • Ching-Yu Shih,
  • Mong-Hsun Tsai,
  • Juey-Jen Hwang,
  • Yi-Chih Wang,
  • Eric Y. Chuang,
  • Chia-Ti Tsai and
  • Sheng-Nan Chang

7 March 2022

Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; contr...

  • Review
  • Open Access
53 Citations
12,452 Views
18 Pages

Large Cell Neuroendocrine Carcinoma of the Lung: Current Understanding and Challenges

  • Elisa Andrini,
  • Paola Valeria Marchese,
  • Dario De Biase,
  • Cristina Mosconi,
  • Giambattista Siepe,
  • Francesco Panzuto,
  • Andrea Ardizzoni,
  • Davide Campana and
  • Giuseppe Lamberti

7 March 2022

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive type of lung cancer, with a complex biology that shares similarities with both small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). The prognosis...

  • Article
  • Open Access
2,785 Views
14 Pages

Safety of Obtaining an Extra Biobank Kidney Biopsy Core

  • Sheila Bermejo,
  • Clara García-Carro,
  • Richard Mast,
  • Ander Vergara,
  • Irene Agraz,
  • Juan Carlos León,
  • Monica Bolufer,
  • Maria-Alejandra Gabaldon,
  • Daniel Serón and
  • Oriol Bestard
  • + 1 author

7 March 2022

Background and objectives: Kidney biopsy (KB) is the “gold standard” for the diagnosis of nephropathies and it is a diagnostic tool that presents a low rate of complications. Nowadays, biobank collections of renal tissue of patients with...

  • Article
  • Open Access
5 Citations
2,656 Views
14 Pages

7 March 2022

This study aimed to evaluate the association between visual impairment (VI) and psychological distress (PD) among older adults in Taiwan. The present cohort study included participants aged >65 years who participated in a physical examination prog...

  • Article
  • Open Access
6 Citations
3,427 Views
10 Pages

Adverse Pregnancy Outcomes and Maternal Chronic Diseases in the Future: A Cross-Sectional Study Using KoGES-HEXA Data

  • Geum Joon Cho,
  • Jiae Kim,
  • Ji Young Kim,
  • Sung Won Han,
  • Soo Bin Lee,
  • Min-Jeong Oh,
  • Sa Jin Kim and
  • Jae Eun Shin

7 March 2022

Adverse pregnancy outcomes (APOs) are associated with an increased risk of chronic diseases, including cardiovascular disease (CVD) and metabolic syndrome (MS), in the future. We designed a large-scale cohort study to evaluate the influence of APOs (...

  • Review
  • Open Access
12 Citations
4,205 Views
10 Pages

HIV-Associated Lymphomas: Progress and New Challenges

  • Georgios N. Pongas and
  • Juan C. Ramos

7 March 2022

The association of human immunodeficiency virus (HIV) and aggressive lymphomas was first reported in 1982. Before the development of effective HIV antiviral therapy, the incidence and the mortality of these lymphomas was high, with patients frequentl...

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J. Clin. Med. - ISSN 2077-0383