Next Article in Journal
Differences in Accuracy and Radiation Dose in Placement of Iliosacral Screws: Comparison between 3D and 2D Fluoroscopy
Previous Article in Journal
Postoperative Complications and Swallowing Function after Jejunal and Skin Flap Reconstruction for Hypopharyngeal Carcinoma—A Multicenter Retrospective Study
Previous Article in Special Issue
Detection of Human Papillomavirus DNA in Paired Peripheral Blood and Cervix Samples in Patients with Cervical Lesions and Healthy Individuals
 
 
Review

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

1
Biotechnology Laboratory, Casaccia Research Center, Biotechnology and Agro-Industry Division, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), 00123 Rome, Italy
2
Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, Italy
3
HPV-Unit, Unità Operativa Semplice Dipartimentale (UOSD) Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Lina Tornesello
J. Clin. Med. 2022, 11(5), 1465; https://doi.org/10.3390/jcm11051465
Received: 19 January 2022 / Revised: 25 February 2022 / Accepted: 4 March 2022 / Published: 7 March 2022
(This article belongs to the Special Issue Oncogenic Human Papillomaviruses)
Human papillomavirus (HPV) still represents an important threat to health worldwide. Better therapy in terms of further improvement of outcomes and attenuation of related side-effects is desirable. The pharmaceutical industry has always targeted natural substances—phytochemicals in particular—to identify lead compounds to be clinically validated and industrially produced as antiviral and anticancer drugs. In the field of HPV, numerous naturally occurring bioactives and dietary phytochemicals have been investigated as potentially valuable in vitro and in vivo. Interference with several pathways and improvement of the efficacy of chemotherapeutic agents have been demonstrated. Notably, some clinical trials have been conducted. Despite being endowed with general safety, these natural substances are in urgent need of further assessment to foresee their clinical exploitation. This review summarizes the basic research efforts conducted so far in the study of anti-HPV properties of bio-actives with insights into their mechanisms of action and highlights the variety of their natural origin in order to provide comprehensive mapping throughout the different sources. The clinical studies available are reported, as well, to highlight the need of uniformity and consistency of studies in the future to select those natural compounds that may be suited to clinical application. View Full-Text
Keywords: HPV; natural; marine; algal; microbial compounds; phytochemicals; bioactives; chemoprevention; combination treatments HPV; natural; marine; algal; microbial compounds; phytochemicals; bioactives; chemoprevention; combination treatments
Show Figures

Figure 1

MDPI and ACS Style

Massa, S.; Pagliarello, R.; Paolini, F.; Venuti, A. Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review. J. Clin. Med. 2022, 11, 1465. https://doi.org/10.3390/jcm11051465

AMA Style

Massa S, Pagliarello R, Paolini F, Venuti A. Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review. Journal of Clinical Medicine. 2022; 11(5):1465. https://doi.org/10.3390/jcm11051465

Chicago/Turabian Style

Massa, Silvia, Riccardo Pagliarello, Francesca Paolini, and Aldo Venuti. 2022. "Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review" Journal of Clinical Medicine 11, no. 5: 1465. https://doi.org/10.3390/jcm11051465

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop