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Journal of Clinical Medicine, Volume 11, Issue 5

March-1 2022 - 317 articles

Cover Story: Paravalvular leak after mitral surgical replacement is frequent. Some of them, especially larger ones, can be clinically significant. Heart failure and hemolysis are the most prevalent clinical manifestations. Surgical reparation is considered the gold-standard therapy in current guidelines, but the percutaneous approach has emerged as an alternative. Transcatheter paravalvular leak closure has shown excellent results with a low rate of complications. Therefore, it is now considered the first option in selected patients in experienced centers. In this review, we summarize the clinical manifestations, diagnosis, procedural details, and results of transcatheter mitral paravalvular leak closure. View this paper 
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Articles (317)

  • Review
  • Open Access
20 Citations
5,168 Views
21 Pages

HIPEC in Peritoneal Metastasis of Gastric Origin: A Systematic Review of Regimens and Techniques

  • Felix Gronau,
  • Linda Feldbruegge,
  • Frauke Oberwittler,
  • Santiago Gonzalez-Moreno,
  • Laurent Villeneuve,
  • Clarisse Eveno,
  • Olivier Glehen,
  • Shigeki Kusamura and
  • Beate Rau

7 March 2022

(1) Background: Peritoneal metastasis in gastric cancer is associated with a poor prognosis. Complete cytoreductive surgery including gastrectomy and complete removal of all peritoneal lesions followed by hyperthermic intraperitoneal chemotherapy (HI...

  • Review
  • Open Access
17 Citations
7,154 Views
12 Pages

Rethinking Resistant Hypertension

  • Gabrielle Bourque and
  • Swapnil Hiremath

7 March 2022

Resistant hypertension is common and known to be a risk factor for cardiovascular events, including stroke, myocardial infarction, heart failure, and cardiovascular mortality, as well as adverse renal events, including chronic kidney disease and end-...

  • Review
  • Open Access
14 Citations
12,367 Views
15 Pages

7 March 2022

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterised by eosinophilic inflammation and esophageal dysfunction symptoms. The recommended first-line treatment options are proton pump inhibitors and swallowed topical steroid...

  • Article
  • Open Access
8 Citations
5,582 Views
10 Pages

7 March 2022

Although idiopathic sudden sensorineural hearing loss (ISSNHL) is uncommon, recurrent ISSNHL is even rarer. The knowledge about factors associated with patient recovery from recurrent episodes is needed to counsel and treat the patients. Medical reco...

  • Article
  • Open Access
22 Citations
3,812 Views
12 Pages

Cardiopulmonary Exercise Performance and Endothelial Function in Convalescent COVID-19 Patients

  • Pasquale Ambrosino,
  • Paolo Parrella,
  • Roberto Formisano,
  • Giovanni Perrotta,
  • Silvestro Ennio D’Anna,
  • Marco Mosella,
  • Antimo Papa and
  • Mauro Maniscalco

7 March 2022

Background: Endothelial dysfunction has been proposed as the common pathogenic background of most manifestations of coronavirus disease 2019 (COVID-19). Among these, some authors also reported an impaired exercise response during cardiopulmonary exer...

  • Article
  • Open Access
1 Citations
2,102 Views
9 Pages

Low Incidence of Hepatocellular Carcinoma after Antiviral Therapy in Patients with Chronic Hepatitis C and Hemophilia

  • In Jung Kim,
  • Sung Hwan Yoo,
  • Sora Kim,
  • Young Youn Cho,
  • Ki Young Yoo,
  • Hyung Joon Kim and
  • Hyun Woong Lee

7 March 2022

Background: Hepatocellular carcinoma (HCC) rarely develops in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). We assessed the incidence of HCC in CHC patients with hemophilia after treatment with pegylated in...

  • Article
  • Open Access
4 Citations
2,416 Views
10 Pages

Cardioprotective Properties of Humoral Factors Released after Remote Ischemic Preconditioning in CABG Patients with Propofol-Free Anesthesia—A Translational Approach from Bedside to Bench

  • Katharina Feige,
  • Carolin Torregroza,
  • Milena Gude,
  • Patrick Maddison,
  • Martin Stroethoff,
  • Sebastian Roth,
  • Giovanna Lurati Buse,
  • Markus W. Hollmann and
  • Ragnar Huhn

7 March 2022

The cardioprotective effect of remote ischemic preconditioning (RIPC) is well detectable in experimental studies but not in clinical trials. Propofol, a commonly used sedative, is discussed to negatively influence the release of humoral factors after...

  • Article
  • Open Access
6 Citations
3,185 Views
14 Pages

Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

  • Elisa Neuvonen,
  • Jenni Lehtisalo,
  • Tiia Ngandu,
  • Esko Levälahti,
  • Riitta Antikainen,
  • Tuomo Hänninen,
  • Tiina Laatikainen,
  • Jaana Lindström,
  • Teemu Paajanen and
  • Hilkka Soininen
  • + 4 authors

7 March 2022

Depression and cognition are associated, but the role of depressive symptoms in lifestyle interventions to prevent dementia needs further study. We investigated the intervention effect on depressive symptoms and their associations with cognition in t...

  • Article
  • Open Access
16 Citations
4,139 Views
14 Pages

Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit

  • Claudia Isonne,
  • Valentina Baccolini,
  • Giuseppe Migliara,
  • Mariateresa Ceparano,
  • Francesco Alessandri,
  • Giancarlo Ceccarelli,
  • Guglielmo Tellan,
  • Francesco Pugliese,
  • Maria De Giusti and
  • Corrado De Vito
  • + 21 authors

7 March 2022

The COVID-19 pandemic has increased the healthcare-associated infection (HAI) risk in intensive care unit (ICU) patients. However, a comparison between patients with and without COVID-19 in terms of HAI incidence has been rarely explored. In this stu...

  • Review
  • Open Access
18 Citations
9,938 Views
15 Pages

7 March 2022

In pre-hospital settings, efficient cardiopulmonary resuscitation (CPR) is challenging; therefore, the application of mechanical CPR devices continues to increase. However, the evidence of the benefits of using mechanical CPR devices in pre-hospital...

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J. Clin. Med. - ISSN 2077-0383