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Antioxidants, Volume 14, Issue 3

March 2025 - 127 articles

Cover Story: Charcot–Marie–Tooth disease (CMT) is the most common hereditary peripheral neuropathy worldwide, with CMT1A being the most prevalent subtype. It is known that CMT1A is caused by a duplication of PMP22, yet the mechanisms of age-dependent neurodegeneration remain elusive. Recent evidence has suggested impaired redox homeostasis in CMT1A, including elevated lipid peroxide levels and decreased glutathione in human patients. These markers are hallmarks of ferroptosis, a novel form of cell stress that can lead to cell death. Ferroptosis has been linked to some hereditary central nervous system disorders, yet none of the peripheral nervous system. Our study provides the first direct evidence of ferroptosis in human CMT1A fibroblasts and Schwann cells, providing mechanistic insight and a new therapeutic direction. View this paper
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Articles (127)

  • Article
  • Open Access
1 Citations
2,323 Views
24 Pages

Korean Mistletoe (Viscum album var. coloratum) Ethanol Extracts Enhance Intestinal Barrier Function and Alleviate Inflammation

  • Ye Jin Yang,
  • Min Jung Kim,
  • Ji Woong Heo,
  • Hun Hwan Kim,
  • Gon Sup Kim,
  • Min Sub Shim,
  • Kwang Youn Kim and
  • Kwang Il Park

Korean mistletoe (Viscum album var. coloratum, KML) offers remarkable therapeutic potential for a variety of diseases. This study aims to evaluate the effects and potential molecular mechanisms of KML ethanol extracts (KMLE), focusing on intestinal b...

  • Article
  • Open Access
4 Citations
5,026 Views
29 Pages

The current research aims to monitor the physicochemical changes in various varieties of extra virgin olive oils (EVOOs) supplemented with exogenous polyphenolic extract from olive fruit, enriched with hydroxytyrosol (HTyr) and its derivatives, compa...

  • Review
  • Open Access
1 Citations
1,433 Views
15 Pages

Production and Role of Nitric Oxide in Endometrial Cancer

  • Seung Geun Yeo,
  • Yeon Ju Oh,
  • Jae Min Lee,
  • Joon Hyung Yeo,
  • Sung Soo Kim and
  • Dong Choon Park

Endometrial cancer ranks as the fourth most common cancer among women in the United States. While early-stage treatment is generally effective with a cure rate of approximately 90%, the five-year survival rate dramatically decreases to 10–15% f...

  • Article
  • Open Access
3 Citations
4,528 Views
31 Pages

Effect of N-Acetylcysteine in Mitochondrial Function, Redox Signaling, and Sirtuin 3 Levels in the Heart During Cardiorenal Syndrome Type 4 Development

  • Isabel Amador-Martínez,
  • Omar Emiliano Aparicio-Trejo,
  • Ana Karina Aranda-Rivera,
  • Bismarck Bernabe-Yepes,
  • Omar Noel Medina-Campos,
  • Edilia Tapia,
  • Carlo César Cortés-González,
  • Alejandro Silva-Palacios,
  • Francisco Javier Roldán and
  • Juan Carlos León-Contreras
  • + 6 authors

Type 4 cardiorenal syndrome (CRS-4) is a pathology in which chronic kidney disease (CKD) triggers the development of cardiovascular disease. CKD pathophysiology produces alterations that can affect the bioenergetics of heart mitochondria, causing oxi...

  • Article
  • Open Access
2,407 Views
17 Pages

The Cluster of Differentiation 5-like protein (CD5L) is produced by tissue-resident macrophages. It is an innate immune mediator protein with a multitude of functions, such as binding of invading microorganisms and oxidised LDL, and it is associated...

  • Article
  • Open Access
8 Citations
2,687 Views
29 Pages

Spirulina, a cyanobacterial biomass, is renowned for its high protein content and bioactive compounds, making it a promising candidate for health-promoting applications. This study explores the ultrasound-assisted deep eutectic solvent (DES) extracti...

  • Article
  • Open Access
2 Citations
3,520 Views
19 Pages

Background: Fine dust exposure worsens oily skin by disrupting lipid metabolism and triggering oxidative inflammation. Scutellaria baicalensis extract-induced exosomes (SBEIEs) have shown anti-inflammatory effects by suppressing reactive oxygen speci...

  • Article
  • Open Access
1 Citations
1,778 Views
27 Pages

The disruption of microglial homeostasis and cytokine release are critical for neuroinflammation post-injury and strongly implicated in retinal neurodegenerative diseases like glaucoma. This study examines microglial responses to chemical hypoxia ind...

  • Article
  • Open Access
4 Citations
4,042 Views
13 Pages

A Comparative Study of Traditional Sun Drying and Hybrid Solar Drying on Quality, Safety, and Bioactive Compounds in “Pingo de Mel” Fig

  • Bárbara R. Henriques,
  • Cláudia M. B. Neves,
  • Marwa Moumni,
  • Gianfranco Romanazzi,
  • Carine Le Bourvellec,
  • Susana M. Cardoso and
  • Dulcineia F. Wessel

Figs are highly perishable, with significant losses due to overripening or failure to meet market standards. Drying is essential to extending their shelf life and reducing food waste. This study evaluated the impact of traditional sun drying and hybr...

  • Article
  • Open Access
1,097 Views
19 Pages

Growth-Associated Protein-43 Loss Promotes Ca2+ and ROS Imbalance in Cardiomyocytes

  • Michele Bevere,
  • Caterina Morabito,
  • Delia Verucci,
  • Noemi Di Sinno,
  • Maria A. Mariggiò and
  • Simone Guarnieri

Growth-Associated Protein-43 (GAP-43) is a calmodulin-binding protein, originally found in neurons, that in skeletal muscle regulates the handling of intracellular Ca2+ dynamics. According to its role in Ca2+ regulation, myotubes from GAP-43 knockout...

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Antioxidants - ISSN 2076-3921