2025 December - 133 articles
Prostate cancer remains a leading cause of cancer-related mortality and castration-resistant prostate cancer (CRPC) is a critical therapeutic challenge. This review establishes a conceptual framework analyzing ferroptosis vulnerability through two pr...
Conventional and electronic cigarette (e-cig) users face an increased risk of cardiorespiratory diseases, driven by well-characterized pathways involving inflammation and oxidative stress (OS). Conventional cigarettes contain numerous harmful chemica...
Aquaculture continues to expand rapidly, increasing the need for nutritional approaches that mitigate oxidative stress, support metabolic homeostasis, and enhance resilience to environmental and dietary challenges [...]
Chronic hyperglycemia inflicts serious cellular damage by inducing oxidative stress through the excessive production of free radicals. This oxidative milieu may impair the cellular redox capacity and disrupt the insulin-like growth factor (IGF) syste...
Two endogenous peptides, β-alanyl-L-histidine, named carnosine (Car), and glycyl-L-histidyl-L-lysine (GHK), derived from the matricellular protein Secreted Protein Acidic and Rich in Cysteine (SPARC), share many beneficial functions. The hydroly...
In agricultural production, Deoxynivalenol (DON) generally exists and contaminates wheat, corn, and other grains, causing intestinal damage and immunotoxicity. Lycopene (LYC), an antioxidant, anti-inflammatory carotenoid, is mainly found in red fruit...
This study examined the protective impact of tributyrin on heat-stressed Taihe silky fowls, providing insight into oxidative status, inflammatory response, and mucosal barrier function. Three hundred chicks were randomly assigned to 6 treatments: con...
Oxidative stress, inflammation, and environmental factors contribute significantly to the development of ocular disorders, including dry eye disease, conjunctivitis, and age-related degenerative changes. In recent years, growing attention has been di...
Protein glycation and oxidation contribute to the pathogenesis of neurodegenerative diseases. This study evaluated the antiglycative and antioxidative effects of donepezil, rivastigmine, galantamine, memantine, lamotrigine, sodium valproate, and carb...
The study evaluated the potential of Thymus mastichina, Lavandula luisiery, and Origanum virens hydrolates—essential oil-rich species found in the Dehesa ecosystem—as natural agents for pork preservation through marination. Hydrolates, th...
Objective: Ongoing debates focus on the role of human leukocyte antigen (HLA) class II expression in shaping clinical phenotypes of chronic inflammatory airway diseases. This study seeks to clarify the impact of class II HLA on chronic obstructive pu...
Thanks to both endogenous and exogenous antioxidants (AOs), the antioxidant defense system ensures redox homeostasis, which is crucial for protecting the body from oxidative stress and maintaining overall health. The food industry also exploits the a...
Chloroplast-to-nucleus ROS retrograde signaling is essential for acclimation of the photosynthetic apparatus to environmental stresses. One of the key mechanisms is the regulation of the photosystem II antenna size depending on light conditions and o...
Oxidative stress is a key contributor to the onset and progression of diverse pathological conditions, including metabolic dysfunction-associated steatotic liver disease (MASLD), neurodegeneration, cardiovascular disorders, and cancer. Conventional a...
Sepsis-induced myocardial dysfunction (SIMD) is a fatal complication with limited therapeutic options. Semicarbazide-sensitive amine oxidase (SSAO) contributes to oxidative stress and leukocyte recruitment, yet its role in SIMD remains unexplored. Th...
Hair growth is orchestrated by a complex cycle comprising the anagen, catagen, telogen, and exogen phases that are largely regulated by dermal papilla cells (DPCs). The disruption of oxidative balance and inflammation impairs follicle function and re...
The exopolysaccharides (EPS) from the mycelial fermentation of Cordyceps sinensis Cs-HK1, especially the low-molecular weight, protein-rich exopolysaccharide fractions (EPS-LM), have previously exhibited significant antioxidant activity. This study f...
The prevalence of chronic diseases, including obesity and related endocrine disorders, has risen significantly in recent decades. As a result, there has been growing interest in fermented foods with probiotic properties, such as kefir, which have pot...
The poor quality of oocytes matured in vitro seriously hinders the application in mammalian assisted reproductive technology (ART). Exploring the regulators and mechanisms influencing oocyte maturation is critical to improve the developmental compete...
The efficacy of phytoextracts is equally affected by the extraction solvent and the extraction method. Details of the solvent type, concentration, density, and other characteristics are associated with the quality of the resultant extract. Some solve...
In the developing lung, oxidative stress caused by relative hyperoxia constitutes a central pathogenic mechanism of neonatal lung injury resulting in bronchopulmonary dysplasia (BPD). The immature postnatal lung is highly susceptible to oxidative dam...
Redox potential controls a vast array of biochemical reactions, and its changes influence the transition from normal to pathological states. However, cellular redox potential is primarily assessed after extraction of water-soluble components (reduced...
Neuroinflammation driven by microglial activation is a hallmark of Alzheimer’s disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial inflammation, yet strategies to modulate its expression remai...
Metabolic dysfunction–associated fatty liver disease (MASLD) is associated with severe forms of liver injury, including fibrosis and cirrhosis. The main risk factors for MASLD—obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and in...
Background: Prostacyclin (PGI2), an abundantly produced bioactive lipid by oviductal epithelial cells, supports preimplantation embryo development by buffering oxidative stress. However, the mechanism linking PGI2 signaling to embryonic redox control...
Glucagon-like peptide-1 receptor agonists and lifestyle interventions effectively treat overt obesity, but the benefits/risks of their combined early intervention during middle age remain unclear. This study investigated whether submaximal-dose lirag...
Background: Aging elevates reactive oxygen species (ROS) and weakens antioxidant defenses, contributing to cardiac dysfunction. The objective of this study was to determine whether sustained activation of skeletal muscle (SkM) Nrf2 preserves cardiac...
Neurological disorders and cardiovascular disease (CVD) remain leading causes of global morbidity and mortality and often coexist, in part through shared mechanisms of chronic inflammation and oxidative stress. Neuroinflammatory signaling, including...
Our study aimed to test the hypothesis that supplementation with a combination of dry grape extracts (DGS) and olive-originated hydroxityrosol (HxT) polyphenols during ovine gestation under moderate nutritional restriction allows for the improvement...
The temperate rainforests of southern Chile host a rich diversity of plants traditionally used in medicine, yet their bioactive potential remains underexplored. This study evaluated the chemical composition, antioxidant capacity, antibacterial activi...
The pivotal role of reactive oxygen species (ROS), especially peroxides, in multiple cell signalling pathways has been well-established. Superoxide dismutase 1 (SOD-1) represents a major intracellular source of hydrogen peroxide. Antigen-dependent ac...
Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity, mortality, and premature death worldwide. Its pathogenesis is complex and incompletely understood, with disrupted methionine metabolism as a key contributor. This p...
Most respiratory diseases are driven by excessive airway inflammation and oxidative stress, yet current therapies often lack durable efficacy or are unsafe. Host-defense peptides, commonly enriched in animal venoms, offer diverse, target-selective sc...
Polyphenols, as natural compounds abundant in plant-derived foods, have been recognised for their human health benefits. This study evaluates the multifunctional properties of BiombalanceTM (BB), a grape seed extract rich in oligomeric procyanidins,...
Lipid peroxide (LPO) accumulation and a depletion of intracellular antioxidants are hallmarks of ferroptosis, a controlled iron-dependent form of cell death. Iron chelators and radical scavengers can stop it, while erastin or iron overload can cause...
Solanum lycopersicum plants were grown in pots amended with biochar and PGPMs (plant growth-promoting microorganisms: Pseudomonas fluorescens and Azotobacter chroococcum), applied singularly and in combination, for three months, after which plants an...
Polyphenols and carbohydrates may modulate exercise-induced oxidative stress through distinct mechanisms: polyphenols via antioxidative properties, and carbohydrates via improved rapidly available energy supply. This randomized controlled trial (RCT)...
In a rat model simulating moderate and relatively high human exposure to cadmium (Cd; 5 and 50 mg/L, respectively, for 12 months), it was examined whether zinc (Zn) supplementation (30 and 60 mg/L, increasing the daily intake of this element by 71% a...
There was a mistake in the published paper [...]
Nickel is a pervasive heavy metal with the potential for multi-route exposure, raising significant concerns regarding systemic toxicity. Although Ni2+ has been implicated in nickel sulfate NiSO4-induced neurotoxicity, its underlying mechanisms remain...
Allium ursinum L. (wild garlic) is a valuable medicinal and culinary plant, rich in bioactive compounds with antioxidant properties. This study evaluated the chemical composition and antioxidant activity of A. ursinum populations growing across eleve...
In vitro maturation (IVM) of oocytes remains suboptimal due to oxidative stress and disrupted cumulus–oocyte communication. Oocyte-derived factors (ODFs) are key mediators of this crosstalk and crucial for oocyte competence. Here, we provide sy...
Redox unbalance, a molecular trait common to neurodegenerative conditions and para-physiological processes like aging, is a critical factor in disease development and in exacerbating progression. The mechanism by which redox imbalance perturbs cellul...
Cancer cell plasticity drives metastasis and therapy resistance through dynamic transitions between epithelial, mesenchymal, and neural crest stem-like (NCSC) states; however, a unifying mechanism that stabilizes these transitions remains undefined....
Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and mo...
Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical fo...
This study investigated the effects of dietary supplementation with Hylocereus polyrhizus juice by-product extract (HJBE) on growth performance, digestive enzyme activity, antioxidant status, immune response, and disease resistance against Edwardsiel...
Male infertility accounts for approximately 50% of reproductive failures, yet its diagnosis and understanding of underlying mechanisms remain limited. The present observational case–control study aimed to examine seminal plasma concentrations o...
Background/Objectives: For many years, herbs and spices have been used, due to their aroma and flavor, in the food industry and cuisine. It is also well known that phytochemicals from these plant parts have many health benefits and are used for the p...
Antioxidant intake from natural sources may enhance defense systems against oxidative stress induced by environmental factors such as cigarette smoke. Watercress (Nasturtium officinale) is an abundant source of antioxidants. This study aimed to deter...
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