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Microorganisms, Volume 7, Issue 12 (December 2019) – 131 articles
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Cover Story (view full-size image) Mycobacterium avium subspecies paratuberculosis (MAP) DNA was detected in 35.4% RA compared to [...] Read more. Mycobacterium avium subspecies paratuberculosis (MAP) DNA was detected in 35.4% RA compared to 20.4% controls (p-value < 0.05, OR = 2.14, 95% CI: 1.12–5.20). The presence of MAP in RA was correlated with SNPs and downregulation in TNFRSF1B expression, in addition to a decrease in osteocalcin blood level, an osteoporosis biomarker. Specifically, osteocalcin was 2.70 ± 0.87 ng/mL in RA, 0.60 ± 0.31 ng/mL in RA infected with MAP, 0.67 ± 0.35 ng/mL in RA associated with rs3397 in TNFRSF1B, compared to the healthy controls (5.31 ± 1.39 ng/mL), and MAP-free RA (3.85 ± 1.31 ng/mL). The study clearly associated MAP with osteoporosis in autoimmune disease patients with key SNP in the TNF receptor superfamily gene, including RA. Overall, a personalized treatment option should be considered in patients with osteoporosis.View this paper.