Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation

Muskhelishvili, Georgi; Forquet, Raphaël; Reverchon, Sylvie; Meyer, Sam; Nasser, William

doi:10.3390/microorganisms7120694

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Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation

Georgi Muskhelishvili

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Agricultural University of Georgia, 0159 Tbilisi, Georgia

INSA-Lyon, CNRS, UMR5240, Microbiologie, Adaptation, Pathogénie, Univ. Lyon, Université Lyon 1, F-69622 Villeurbanne, France

Author to whom correspondence should be addressed.

Microorganisms 2019, 7(12), 694; https://doi.org/10.3390/microorganisms7120694

Received: 28 October 2019 / Revised: 28 November 2019 / Accepted: 9 December 2019 / Published: 13 December 2019

(This article belongs to the Special Issue Role of Bacterial Chromatin in Environmental Sensing, Adaptation and Evolution)

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Abstract

Recent studies strongly suggest that in bacteria, both the genomic pattern of DNA thermodynamic stability and the order of genes along the chromosomal origin-to-terminus axis are highly conserved and that this spatial organization plays a crucial role in coordinating genomic transcription. In this article, we explore the relationship between genomic sequence organization and transcription in the commensal bacterium Escherichia coli and the plant pathogen Dickeya. We argue that, while in E. coli the gradient of DNA thermodynamic stability and gene order along the origin-to-terminus axis represent major organizational features orchestrating temporal gene expression, the genomic sequence organization of Dickeya is more complex, demonstrating extended chromosomal domains of thermodynamically distinct DNA sequences eliciting specific transcriptional responses to various kinds of stress encountered during pathogenic growth. This feature of the Dickeya genome is likely an adaptation to the pathogenic lifestyle utilizing differences in genomic sequence organization for the selective expression of virulence traits. We propose that the coupling of DNA thermodynamic stability and genetic function provides a common organizational principle for the coordinated expression of genes during both normal and pathogenic bacterial growth. View Full-Text

Keywords: bacteria; chromosomal origin-to-terminus axis; DNA thermodynamic stability; DNA supercoiling; nucleoid-associated proteins; transcription; chromosomal domains; genetic regulation

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Muskhelishvili, G.; Forquet, R.; Reverchon, S.; Meyer, S.; Nasser, W. Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation. Microorganisms 2019, 7, 694. https://doi.org/10.3390/microorganisms7120694

AMA Style

Muskhelishvili G, Forquet R, Reverchon S, Meyer S, Nasser W. Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation. Microorganisms. 2019; 7(12):694. https://doi.org/10.3390/microorganisms7120694

Chicago/Turabian Style

Muskhelishvili, Georgi, Raphaël Forquet, Sylvie Reverchon, Sam Meyer, and William Nasser. 2019. "Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation" Microorganisms 7, no. 12: 694. https://doi.org/10.3390/microorganisms7120694

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Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation

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