2026 March - 213 articles
Tebipenem is a new carbapenem antibiotic that binds to penicillin-binding proteins (PBPs). Given the need for effective antibiotics against multidrug-resistant (MDR) bacteria, this review evaluated the in vitro antimicrobial activity of tebipenem aga...
Recurrent vulvovaginal candidiasis (RVVC) affects 5–8% of women of reproductive age. Host genetic factors, particularly single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs), may influence RVVC susceptibility by impairing vaginal...
The opportunistic pathogen Pseudomonas aeruginosa poses a serious threat to immunocompromised patients. Monosodium glutamate (MSG), a widely used flavor enhancer, has been reported to possess anti-inflammatory and antioxidant properties. However, its...
Acidithiobacillus caldus is perpetually exposed to multiple extreme environmental stresses. CsrA, functioning as a post-transcriptional regulator of physiological metabolism, acts as a differential modulator, facilitating more economical and efficien...
We report on the isolation and comprehensive genomic and biochemical characterization of Aspergillus fumigatus VP2T, a thermophilic filamentous fungus recovered from Himalayan Forest soil with exceptional lignocellulolytic capacity. Whole-genome sequ...
Approximately 20% of China’s land area is desertified or highly desertifiable, where loose sandy soil and low nutrient availability restrict plant growth. Microbial inoculants, as an emerging ecological restoration technology, play a key role i...
International travel has increased significantly in recent years. Many travellers are immunocompromised, making them more susceptible to infectious diseases due to their weakened immune systems. This narrative review provides an overview of infection...
Advances in sequencing technologies have transformed human microbiome research, yet most analyses still rely on species-level profiles. However, strains rather than species represent the true ecological and functional units of the microbiome. Individ...
Early life represents a critical developmental programming window during which nutrition and microbial exposures shape long-term physiological function. Feeding mode is a major determinant of infant gut microbiota assembly and metabolic activity. Thi...
The artificially modified Bacillus thuringiensis (Bt) protein can target lepidopteran pests, and planting genetically modified crops with insect-resistant traits is environmentally friendly. However, it is still uncertain whether the exogenous insect...
Animal viral infectious diseases continue to pose a persistent threat to the development of global animal husbandry and animal health [...]
Gastrointestinal (GI) cancers remain a leading cause of morbidity and mortality globally, and their etiology is recognized as a multifactorial process driven by the interplay of genetic susceptibility, environmental exposures, and lifestyle-related f...
The microbial production of 1,5-pentanediol (1,5-PDO), a versatile platform chemical with extensive industrial applications, remains limited by suboptimal fermentation titers and incomplete understanding of metabolic bottlenecks. To address these cha...
Bursaphelenchus rainulfi is a pine-associated, non-pathogenic nematode that serves as a motile comparative species for evaluating nematophagous fungi. We investigated the in vitro biocontrol activity of Purpureocillium takamizusanense strain PMEPF27,...
Climate warming—a key driver of global change—significantly affects soil microbial communities and network stability. Biological soil crusts (biocrusts) help mitigate these impacts while maintaining soil ecological functions and biodivers...
Antimicrobial resistance (AMR) emerges and circulates across interconnected human, animal, food, and environmental reservoirs; however, food fermentation systems remain underexplored as indicators of local AMR pressure, even though artisanal dairy fe...
Urinary tract infections (UTIs) are the most frequent infections in hospitalized and outpatient settings, where Escherichia coli is the predominant pathogen. Conventional diagnostic and antimicrobial susceptibility testing (AST) methods are time-cons...
Water-associated microorganisms have re-emerged as a central public health concern, reflecting how microbial dynamics in water reflect current social, climatic, and infrastructural pressures [...]
Clusters of acute flaccid paralysis (AFP) caused by oral vaccine-derived poliovirus (VDPV) in 2022 and sporadic outbreaks in New York and Gaza highlight the ongoing risk of polio, alongside the persistent global threat posed by wild-type poliovirus....
Fish host complex intestinal bacterial communities that contribute to a wide range of functions, from nutrient assimilation to modulation of the immune system. Understanding how environmental and host-related factors shape the fish gut microbiota is...
Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths. While intestinal microbiota dysbiosis is linked to CRC, the direct role of intratumoral bacteria in metastasis remains poorly unde...
African swine fever (ASF), a highly contagious and lethal viral disease caused by the African swine fever virus (ASFV), poses a severe threat to the global swine industry. Recent outbreaks across Asia, Europe, and the Caribbean are exacerbating the c...
The growing emphasis on sustainability, regional distinctiveness, and spontaneous fermentation in winemaking necessitates a more comprehensive understanding of local yeast populations and their functional mechanisms. In total, 115 indigenous yeast st...
Resistance surveillance programmes are essential for choosing the most appropriate eradication therapy for the stomach pathogen Helicobacter pylori. This study aimed to determine H. pylori antimicrobial resistance rates in Ireland. H. pylori was cult...
This study evaluated the effects of supplementing Alpinia katsumadai and Wurfbainia vera extracts on the growth performance, antioxidant capacity, intestinal metabolites, and microbiota of Danzhou chickens. Using Danzhou broilers, we examined the ind...
Hepatitis B virus (HBV) remains a major global public health challenge, and its early screening is essential for controlling transmission and improving treatment outcomes. We analyzed serum samples from 422 participants via Matrix-assisted laser deso...
Staphylococcus epidermidis is a leading opportunistic pathogen in medical device-associated infections due to its ability to adhere to abiotic materials and develop biofilms that are difficult to eradicate. This study investigated the antibiofilm pot...
Bacillus coagulans has attracted widespread attention in the treatment of irritable bowel syndrome due to its multiple probiotic functions, yet its specific molecular mechanisms remain unclear, and the efficacy of probiotics exhibits significant stra...
The global spread of high-risk clo1nes (HRCs) of multidrug-resistant (MDR) Pseudomonas aeruginosa has hindered infection control and treatment strategies worldwide. In Colombia, globally relevant HRCs such as ST235 and ST111 have been widely reported...
Glycosphingolipids are amphiphilic compounds that feature sugar or glycan moieties installed onto a ceramide lipid. The synthesis of glycosphingolipids by members of the human gut microbiome, and their known immune stimulating activity, have made the...
Marine mesozooplankton (0.2–20 mm), as a critical trophic link between primary producers and higher trophic levels, are pivotal drivers of trophic cascades regulating pelagic ecosystem structure and function. This review synthesizes recent adva...
Volatile fatty acids (VFAs), the primary end-products of microbial fermentation in the ruminant forestomach, supply approximately 70% of the host’s energy requirements and play a pivotal role in maintaining energy homeostasis. While the mechani...
Bioturbating animals move around large amounts of sediment, changing its physicochemical properties and biogeochemical processes. The present study assessed the role of the ghost shrimp Lepidophthalmus louisianensis, a major coastal bioturbator in th...
Human immunodeficiency virus (HIV) remains a major global health challenge, requiring accurate diagnostic testing for early detection. Chemiluminescent immunoassay screening, particularly the Architect HIV Ag/Ab Combo assay, followed by immunoblot co...
Honeybee (Apis mellifera) colony density is frequently assumed to influence the level of Nosema ceranae infestation in managed colonies. In Slovakia, winter bottom beehive debris (dead worker bees) is routinely collected between January and February,...
This study investigated the effects of isoacid supplementation on in vitro rumen fermentation characteristics, nutrient degradability, and bacterial community diversity in yaks using corn silage–highland barley straw-based substrates. An in vit...
Soybean meal (SBM) is a foundational protein source, but its industrial application is constrained by a complex matrix of anti-nutritional factors (ANFs). This review provides a critical synthesis of the biochemical transition from raw SBM to ferment...
Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant TB (MDR-TB), remains a significant public health challenge in rural South Africa, where diagnostic and treatment infrastructure is limited. This study aimed to assess resistance pa...
Microorganisms such as Arthrobacter spp. are important agents of biodeterioration in cultural heritage (CH) environments, causing orange–yellow chromatic alterations and contributing to substrate degradation. This study evaluates two complement...
Brucella anthropi is an emerging opportunistic pathogen characterized by intrinsic resistance to most
Bacterial membrane vesicles (BMVs) are non-replicative, bilayered nanostructures secreted by both Gram-negative and Gram-positive bacteria. Rather than being passive byproducts of cell envelope turnover, BMVs are increasingly recognized as regulated...
This study was conducted to understand how applied potential modulates metabolic flux toward succinic acid during xylose electro-fermentation by Actinobacillus succinogenes under varying feed concentrations (15, 20, 25 g/L). Electro-fermentations wer...
Humans have made tremendous efforts to explore how biodiversity changes affect ecosystem processes and human well-being. It has been found that, in addition to biodiversity, various drivers of global change also play significant roles in ecosystem fu...
The isolation of locally adapted rhizobial strains with high symbiotic activity represents an effective strategy for increasing soybean yield under extreme environmental conditions. In this study, seven novel strains were isolated from nodules of soy...
Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection predominantly affecting immunocompromised patients. Trimethoprim–sulfamethoxazole (TMP–SMX) remains the standard therapy but is often limited by severe t...
The role of soft tissue reconstruction in infection control of knee periprosthetic joint infection (PJI) treated with a two-stage exchange strategy remains controversial. This retrospective observational study analysed consecutive patients with chron...
Soil salinization and heavy metal pollution represent significant global challenges to farmland sustainability and food security. Globally, over 800 million hectares of land are affected by salinity, with approximately 17% of cultivated land exhibiti...
Soil salinization is a major constraint on sustainable agriculture worldwide, highlighting the need for stress-tolerant plant growth-promoting rhizobacteria (PGPR) for salt-affected soils. A moderately halophilic and alkali-tolerant bacterium, Staphy...
Enteropathogenic Escherichia coli (EPEC) disrupts intestinal barrier integrity, induces inflammation, and alters gut microbial balance, leading to diarrhea and growth impairment. Probiotics are considered promising alternatives to antibiotics for man...
The development of effective remediation strategies for aniline-contaminated sites has become a significant research focus in environmental science. This study aimed to construct a highly efficient aniline-degrading synthetic microbial consortium gui...
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