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Pathogens, Volume 9, Issue 9

September 2020 - 105 articles

Cover Story: The management of antibody-mediated rejection (AMR) for improving the long-term prognosis of transplants remains immensely challenging. As a diagnostic method, current studies mainly focus on the diagnostic value of immunoglobulin (Ig) G antibodies against human leukocyte antigen (HLA) expressed in donor-derived vascular endothelial cells, primarily due to their antigen specificity. On the other hand, IgM donor-specific anti-HLA antibodies (DSAs) have not demonstrated any clinical significance due to the high probability of non-specific reactions in the field of transplantation. However, it is well known that the IgM antibody is the first antibody isotype produced during foreign antigen invasion. In this article, we would like to elucidate the great potential of IgM antibodies against donor-specific HLA in supernatants from cultured peripheral blood mononuclear cells, as predictors of AMR development.View this paper
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Articles (105)

  • Article
  • Open Access
7 Citations
5,289 Views
13 Pages

Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model

  • William S. Lawrence,
  • Jennifer E. Peel,
  • Satheesh K. Sivasubramani,
  • Wallace B. Baze,
  • Elbert B. Whorton,
  • David W. C. Beasley,
  • Jason E. Comer,
  • Dallas E. Hughes,
  • Losee L. Ling and
  • Johnny W. Peterson

22 September 2020

The use of antibiotics is a vital means of treating infections caused by the bacteria Bacillus (B.) anthracis. Importantly, with the potential future use of multidrug-resistant strains of B. anthracis as bioweapons, new antibiotics are needed as alte...

  • Article
  • Open Access
13 Citations
5,456 Views
22 Pages

Transposon Insertion in the purL Gene Induces Biofilm Depletion in Escherichia coli ATCC 25922

  • Virginio Cepas,
  • Victoria Ballén,
  • Yaiza Gabasa,
  • Miriam Ramírez,
  • Yuly López and
  • Sara Mª Soto

22 September 2020

Current Escherichia coli antibiofilm treatments comprise a combination of antibiotics commonly used against planktonic cells, leading to treatment failure. A better understanding of the genes involved in biofilm formation could facilitate the develop...

  • Review
  • Open Access
39 Citations
8,163 Views
20 Pages

Orthohantaviruses, Emerging Zoonotic Pathogens

  • Emmanuel Kabwe,
  • Yuriy Davidyuk,
  • Anton Shamsutdinov,
  • Ekaterina Garanina,
  • Ekaterina Martynova,
  • Kristina Kitaeva,
  • Moffat Malisheni,
  • Guzel Isaeva,
  • Tatiana Savitskaya and
  • Richard A. Urbanowicz
  • + 4 authors

22 September 2020

Orthohantaviruses give rise to the emerging infections such as of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in Eurasia and the Americas, respectively. In this review we will provide a comprehensive analysis...

  • Article
  • Open Access
10 Citations
4,267 Views
20 Pages

In Silico Identification of Novel Immunogenic Secreted Proteins of Mycoplasma bovis from Secretome Data and Experimental Verification

  • Ihsanullah Shirani,
  • Hui Zhang,
  • Gang Zhao,
  • Siyi Lu,
  • Marawan A Marawan,
  • Ali Dawood,
  • Yingyu Chen,
  • Xi Chen,
  • Jianguo Chen and
  • Changmin Hu
  • + 2 authors

21 September 2020

Mycoplasma bovis is a major pathogen, responsible for bovine respiratory diseases worldwide. The present lack of effective control measures leaves cattle owners at considerable perpetual risk of M. bovis outbreaks. In this study, we identified M. bov...

  • Article
  • Open Access
14 Citations
4,415 Views
13 Pages

Salmonella and Antimicrobial Resistance in Wild Rodents—True or False Threat?

  • Magdalena Skarżyńska,
  • Magdalena Zając,
  • Ewelina Kamińska,
  • Arkadiusz Bomba,
  • Jacek Żmudzki,
  • Artur Jabłoński and
  • Dariusz Wasyl

21 September 2020

Transmission of pathogenic and resistant bacteria from wildlife to the bacterial gene pool in nature affects the ecosystem. Hence, we studied intestine content of five wild rodent species: the yellow-necked wood mouse (Apodemus flavicollis, n = 121),...

  • Article
  • Open Access
5 Citations
3,296 Views
12 Pages

21 September 2020

This study assessed the impact of a PRRSV (porcine reproductive and respiratory syndrome virus) recombinant strain (Horsens strain) on the reproductive performance of naïve pregnant sows in the last third of gestation. Fifteen sows were included...

  • Article
  • Open Access
6 Citations
3,615 Views
9 Pages

20 September 2020

Tick-borne pathogens cause economically significant diseases in cattle. Theileria spp. are parasitic protozoa and the causative agent of bovine theileriosis. Here we report the distribution and risk factors of bovine Theileria using blood samples tak...

  • Article
  • Open Access
13 Citations
4,651 Views
17 Pages

Effects of Mustelid gammaherpesvirus 1 (MusGHV-1) Reactivation in European Badger (Meles meles) Genital Tracts on Reproductive Fitness

  • Ming-shan Tsai,
  • Ursula Fogarty,
  • Andrew W. Byrne,
  • James O’Keeffe,
  • Chris Newman,
  • David W. Macdonald and
  • Christina D. Buesching

20 September 2020

Reactivation of latent Gammaherpesvirus in the genital tract can lead to reproductive failure in domestic animals. Nevertheless, this pathophysiology has not received formal study in wild mammals. High prevalence of Mustelid gammaherpesvirus 1 (MusGH...

  • Article
  • Open Access
3 Citations
3,898 Views
20 Pages

Does Curcumin Have a Role in the Interaction between Gut Microbiota and Schistosoma mansoni in Mice?

  • Assmaa Anter,
  • Mohamed Abd El-Ghany,
  • Marwa Abou El Dahab and
  • Noha Mahana

19 September 2020

There is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on...

  • Review
  • Open Access
16 Citations
8,947 Views
19 Pages

18 September 2020

Infectious long-noncoding (lnc) RNAs related to plants can be of both viral and non-viral origin. Viroids are infectious plant lncRNAs that are not related to viruses and carry the circular, single-stranded, non-coding RNAs that replicate with host e...

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Pathogens - ISSN 2076-0817