Pathogens, Volume 9, Issue 9 (September 2020) – 105 articles
Cover Story (view full-size image):
The management of antibody-mediated rejection (AMR) for improving the long-term prognosis of transplants remains immensely challenging. As a diagnostic method, current studies mainly focus on the diagnostic value of immunoglobulin (Ig) G antibodies against human leukocyte antigen (HLA) expressed in donor-derived vascular endothelial cells, primarily due to their antigen specificity. On the other hand, IgM donor-specific anti-HLA antibodies (DSAs) have not demonstrated any clinical significance due to the high probability of non-specific reactions in the field of transplantation. However, it is well known that the IgM antibody is the first antibody isotype produced during foreign antigen invasion. In this article, we would like to elucidate the great potential of IgM antibodies against donor-specific HLA in supernatants from cultured peripheral blood mononuclear cells, as predictors of
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