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Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows

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Zoetis Manufacturing & Research Spain S.L., Ctra Camprodon s/n, 17813 Finca La Riba, Spain
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National Veterinary Institute, Technical University of Denmark, 2800 Lyngby, Denmark
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Department of Health and Medical Sciences, Institute for Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark
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Zoetis Inc., 333 Portage St, Kalamazoo, MI 49007, USA
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(9), 772; https://doi.org/10.3390/pathogens9090772
Received: 10 September 2020 / Revised: 17 September 2020 / Accepted: 18 September 2020 / Published: 21 September 2020
(This article belongs to the Section Animal Pathogens)
This study assessed the impact of a PRRSV (porcine reproductive and respiratory syndrome virus) recombinant strain (Horsens strain) on the reproductive performance of naïve pregnant sows in the last third of gestation. Fifteen sows were included: four negative reproductive controls (NTX), five infected with a PRRSV-1 field strain (Olot/91, T01), and six infected with the recombinant PRRSV-1 strain (Horsens strain, T02). Piglets were monitored until weaning. Reproductive performance was the primary variable. In sows, viremia and nasal shedding (T01 and T02 groups), and, in piglets, viral load in blood and in lungs, as well as macroscopic lung lesions (T01 and T02 groups), were the secondary variables. The reproductive performance results were numerically different between the two challenged groups. Moreover, viral loads in blood were 1.83 × 106 ± 9.05 × 106 copies/mL at farrowing, 1.05 × 107 ± 2.21 × 107 copies/mL at weaning from piglets born from T01 animals and 1.64 × 103 ± 7.62 × 103 copies/mL at farrowing, 1.95 × 103 ± 1.17 × 104 copies/mL at weaning from piglets born from T02 sows. Overall, 68.8% of T01 piglets and 38.1% of T02 piglets presented mild lung lesions. In conclusion, the results suggest that Horsens strain is less virulent than the field strain Olot/91 under these experimental conditions. View Full-Text
Keywords: PRRS; MLV; recombinant PRRS; MLV; recombinant
MDPI and ACS Style

Genís, S.; Kvisgaard, L.K.; Larsen, L.E.; Taylor, L.P.; Calvert, J.G.; Balasch, M. Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows. Pathogens 2020, 9, 772. https://doi.org/10.3390/pathogens9090772

AMA Style

Genís S, Kvisgaard LK, Larsen LE, Taylor LP, Calvert JG, Balasch M. Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows. Pathogens. 2020; 9(9):772. https://doi.org/10.3390/pathogens9090772

Chicago/Turabian Style

Genís, Sandra, Lise K. Kvisgaard, Lars E. Larsen, Lucas P. Taylor, Jay G. Calvert, and Mònica Balasch. 2020. "Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows" Pathogens 9, no. 9: 772. https://doi.org/10.3390/pathogens9090772

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