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Article

Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model

1
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Directorate of Environmental Health Effects Laboratory, Naval Medical Research Unit, Dayton, OH 45433, USA
4
Department of Comparative Medicine, University of Texas MD Anderson Cancer Center, Bastrop, TX 78602, USA
5
Institutional Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX 77555, USA
6
NovoBiotic Pharmaceuticals, LLC, Cambridge, MA 02138, USA
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(9), 773; https://doi.org/10.3390/pathogens9090773
Received: 21 August 2020 / Revised: 17 September 2020 / Accepted: 18 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Anthrax Treatment)
The use of antibiotics is a vital means of treating infections caused by the bacteria Bacillus (B.) anthracis. Importantly, with the potential future use of multidrug-resistant strains of B. anthracis as bioweapons, new antibiotics are needed as alternative therapeutics. In this blinded study, we assessed the protective efficacy of teixobactin, a recently discovered antibiotic, against inhalation anthrax infection in the adult rabbit model. New Zealand White rabbits were infected with a lethal dose of B. anthracis Ames spores via the inhalation route, and blood samples were collected at various times to assess antigenemia, bacteremia, tissue bacterial load, and antibody production. Treatments were administered upon detection of B. anthracis protective antigen in the animals’ sera. For comparison, a fully protective dose of levofloxacin was used as a positive control. Rabbits treated with teixobactin showed 100% survival following infection, and the bacteremia was completely resolved by 24–48 h post-treatment. In addition, the bacterial/spore loads in tissues of the animals treated with teixobactin were either zero or dramatically less relative to that of the negative control animals. Moreover, microscopic evaluation of the tissues revealed decreased pathology following treatment with teixobactin. Overall, these results show that teixobactin was protective against inhalation anthrax infection in the rabbit model, and they indicate the potential of teixobactin as a therapeutic for the disease. View Full-Text
Keywords: Bacillus anthracis; anthrax; inhalation; infection; antibiotic; rabbit model; protective antigen Bacillus anthracis; anthrax; inhalation; infection; antibiotic; rabbit model; protective antigen
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MDPI and ACS Style

Lawrence, W.S.; Peel, J.E.; Sivasubramani, S.K.; Baze, W.B.; Whorton, E.B.; Beasley, D.W.C.; Comer, J.E.; Hughes, D.E.; Ling, L.L.; Peterson, J.W. Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model. Pathogens 2020, 9, 773. https://doi.org/10.3390/pathogens9090773

AMA Style

Lawrence WS, Peel JE, Sivasubramani SK, Baze WB, Whorton EB, Beasley DWC, Comer JE, Hughes DE, Ling LL, Peterson JW. Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model. Pathogens. 2020; 9(9):773. https://doi.org/10.3390/pathogens9090773

Chicago/Turabian Style

Lawrence, William S., Jennifer E. Peel, Satheesh K. Sivasubramani, Wallace B. Baze, Elbert B. Whorton, David W.C. Beasley, Jason E. Comer, Dallas E. Hughes, Losee L. Ling, and Johnny W. Peterson 2020. "Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model" Pathogens 9, no. 9: 773. https://doi.org/10.3390/pathogens9090773

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