Table of Contents
Pathogens, Volume 8, Issue 1 (March 2019) – 41 articles
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Cover Story (view full-size image) Model for cap-independent translation mediated by a plant viral sequence in mammalian cells. The [...] Read more. Model for cap-independent translation mediated by a plant viral sequence in mammalian cells. The panicum mosaic virus-like translation element (PTE), found in the 3’ untranslated region of several plant viruses, binds translation initiation factor eIF4E (4E) via a G-rich bulge in a pseudoknot (red dashed line). eIF4E also binds eIF4G (4G), which recruits other initiation factors (not shown). Long-distance base pairing (black dashed line) places the factors near or on the 5’ end, to which they recruit the 40S ribosomal subunit, which then scans to the start codon (AUG), where protein synthesis begins. Kraft et al. show that the PTE of a plant virus functions efficiently in mammalian cells and extracts, possibly because of the conserved structure of eIF4E in plants and animals. This leads the authors to propose that such PTE-like elements may exist in mammalian viral or host mRNAs. View this paper.