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Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond

1
Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
2
Institute for Infection and Immunity, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Pathogens 2019, 8(1), 40; https://doi.org/10.3390/pathogens8010040
Received: 10 March 2019 / Revised: 19 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Immunology of Fungal Infections)
Over the last decades, fungal infections have emerged as a growing threat to human health. Although the human body is at potential risk, various body sites host several commensal fungal species, including Candida albicans. In healthy individuals, C. albicans colonizes different mucosal surfaces without causing harm, while under diverse circumstances the fungus can proliferate and cause disease. In this context, the understanding of host–C. albicans interactions in health and during infection may lead to novel therapeutic approaches. Importantly, host cells express pattern recognition receptors (PRRs), which sense conserved fungal structures and orchestrate innate immune responses. Herein, important findings on the topic of the recognition of C. albicans at host barrier sites are discussed. This review briefly summarizes the importance and functions of myeloid PRRs, reviews the fungal recognition and biology of stromal cells, and highlights important C. albicans virulence attributes during site-specific proliferation and invasion. View Full-Text
Keywords: antifungal immunity; host–fungus interaction; mucosal tissue antifungal immunity; host–fungus interaction; mucosal tissue
MDPI and ACS Style

Swidergall, M. Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond. Pathogens 2019, 8, 40.

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