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Pathogens 2019, 8(1), 24; https://doi.org/10.3390/pathogens8010024

Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group

1
Civil hospices of Lyon. Department of Parasitology and Mycology, Croix Rousse Hospital, 69317 Lyon, France
2
Assistance Publique-Hôpitaux de Marseille, Department of Parasitology, Timone Hospital, 13005 Marseille, France
3
Assistance Publique-Hôpitaux de Paris, Department of Obstetrics and Gynecology, Louis Mourier Hospital, Colombes, Université Paris-Diderot, Paris, Inserm UMR1137 IAME: Infection, 75013 Paris, France
4
Sorbonne Université, INSERM, Institut Pierre-Louis d’Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, 75651 Paris, France
5
Assistance Publique-Hôpitaux de Paris, Department of Neonatology, Trousseau Hospital, 75012 Paris, France
6
Assistance Publique-Hôpitaux de Marseille, Ophtalmology Consultations, Sainte Marguerite Hospital, 13274 Marseille, France
7
Assistance Publique-Hôpitaux de Paris, Department of Parasitology-Mycology, Pitié-Salpêtrière/Charles Foix University Hospital, 75651 Paris, France
8
Assistance Publique-Hôpitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France
*
Author to whom correspondence should be addressed.
Received: 21 January 2019 / Revised: 31 January 2019 / Accepted: 3 February 2019 / Published: 18 February 2019
(This article belongs to the Section Human Pathogens)
Full-Text   |   PDF [288 KB, uploaded 20 February 2019]

Abstract

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. There is no consensus regarding screening during pregnancy, prenatal/postnatal treatment or short or medium term follow-up. Since 1992, France has offered systematic serological testing to non-immune pregnant women, monthly until delivery. Any maternal infection is thus detected; moreover, diagnosis of congenital infection can be made at birth and follow-up can be provided. “Guidelines” drawn up by a multidisciplinary group are presented here, concerning treatment, before and after birth. The recommendations are based on the regular analysis of the literature and the results of the working group. The evaluation of the recommendations takes into account the robustness of the recommendation and the quality of the evidence. View Full-Text
Keywords: congenital toxoplasmosis; guidelines; treatment of fetal infections; follow-up of congenital infection congenital toxoplasmosis; guidelines; treatment of fetal infections; follow-up of congenital infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Peyron, F.; L’ollivier, C.; Mandelbrot, L.; Wallon, M.; Piarroux, R.; Kieffer, F.; Hadjadj, E.; Paris, L.; Garcia –Meric, P. Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group. Pathogens 2019, 8, 24.

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