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Life, Volume 11, Issue 12

December 2021 - 158 articles

Cover Story: Due to a reduced immune function in elderly patients, young patients with a robust immune system are theoretically expected to benefit more from the anti-PD1 immunotherapy approach. In contrast to this hypothesis, recent studies in patients with metastatic melanoma have demonstrated that immunotherapy, especially with anti-PD1 treatment, is less effective in patients below 65 years, on average, with significantly lower responses and reduced overall survival compared to patients above 65 years of age. Besides, data on young patients are even more sparse. Hence, in this review, we focus on age-dependent differences in the previously described resistance mechanisms to the treatment, and discuss the development of potential combination treatment strategies for enhancing the anti-tumor efficacy of anti-PD1 treatment in young melanoma patients. View this paper.
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Articles (158)

  • Article
  • Open Access
11 Citations
4,440 Views
13 Pages

Atopic Dermatitis Severity, Patient Perception of the Disease, and Personality Characteristics: How Are They Related to Quality of Life?

  • Liborija Lugović-Mihić,
  • Jelena Meštrović-Štefekov,
  • Iva Ferček,
  • Nives Pondeljak,
  • Elvira Lazić-Mosler and
  • Ana Gašić

20 December 2021

Introduction: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that greatly affects patients’ quality of life, psychological condition, and social relationships. Materials And Methods: To analyze different aspects of A...

  • Article
  • Open Access
6 Citations
3,914 Views
12 Pages

It More than Adds Up: Interaction of Antibiotic Mixing and Temperature

  • Marie-Claire Danner,
  • Sharon Omonor Azams,
  • Anne Robertson,
  • Daniel Perkins,
  • Volker Behrends and
  • Julia Reiss

20 December 2021

Use of antibiotics for the treatment and prevention of bacterial infections in humans, agri- and aquaculture as well as livestock rearing leads to antibiotic pollution of fresh water and these antibiotics have an impact on free-living bacteria. While...

  • Article
  • Open Access
8 Citations
3,140 Views
20 Pages

20 December 2021

Alfalfa (Medicago sativa L.) production is affected by many factors, including management practices, soil conditions, and the environmental elements of the target area. Varietal differences, in terms of agronomic performance and forage yield, among 5...

  • Review
  • Open Access
7 Citations
5,758 Views
16 Pages

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms

  • Gianmarco Stati,
  • Francesca Passaretta,
  • Florelle Gindraux,
  • Lucia Centurione and
  • Roberta Di Pietro

20 December 2021

In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after...

  • Article
  • Open Access
1 Citations
3,445 Views
14 Pages

20 December 2021

We examined the long-term relationship of psychosocial risk and health behaviors on clinical events in patients awaiting heart transplantation (HTx). Psychosocial characteristics (e.g., depression), health behaviors (e.g., dietary habits, smoking), m...

  • Review
  • Open Access
4 Citations
4,580 Views
22 Pages

20 December 2021

Expression and functions of microRNAs (miRNAs) have been widely investigated in cancer treatment-induced complications and as a response to physical activity, respectively, but few studies focus on the application of miRNAs as biomarkers in exercise-...

  • Article
  • Open Access
15 Citations
4,715 Views
9 Pages

Considering Predictive Factors in the Diagnosis of Clinically Significant Prostate Cancer in Patients with PI-RADS 3 Lesions

  • Caleb Natale,
  • Christopher R. Koller,
  • Jacob W. Greenberg,
  • Joshua Pincus and
  • Louis S. Krane

19 December 2021

The use of multi-parametric magnetic resonance imaging (mpMRI) in conjunction with the Prostate Imaging Reporting and Data System (PI-RADS) is standard practice in the diagnosis, surveillance, and staging of prostate cancer. The risk associated with...

  • Case Report
  • Open Access
5 Citations
3,783 Views
17 Pages

19 December 2021

The aim of this study is to describe bilateral optic disc swelling in three consecutive patients with Blau syndrome or cryopyrin-associated periodic syndrome at a single institution. Case 1 was a 30-year-old woman receiving 25 mg etanercept twice wee...

  • Article
  • Open Access
6 Citations
3,081 Views
13 Pages

Modulation of Epithelial Mesenchymal Transition after AGTR-1 Gene Edition by Crispr/Cas9 and Losartan Treatment in Mammary Tumor Cell Line: A Comparative Study between Human and Canine Species

  • Marina Gobbe Moschetta-Pinheiro,
  • Jucimara Colombo,
  • Bianca Lara Venâncio de Godoy,
  • Julia Ferreira Balan,
  • Bianca Carlos Nascimento and
  • Debora Aparecida Pires de Campos Zuccari

18 December 2021

Breast cancer is the most prevalent tumor type among women and female dogs. Tumor malignancy is characterized by the epithelial-to-mesenchymal transition (EMT) which leads to the metastasis formation. The inhibition of angiotensin II type I receptor...

  • Article
  • Open Access
4 Citations
3,907 Views
13 Pages

18 December 2021

The variable domains of heavy-chain antibodies, known as nanobodies, are potential substitutes for IgG antibodies. They have similar affinities to antigens as antibodies, but are more heat resistant. Their small size allows us to exploit computationa...

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Life - ISSN 2075-1729