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Article

Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies

1
Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India
2
Australian Centre for Astrobiology, and School of Biological, Earth and Environmental Sciences, University of New South Wales, Kensington, NSW 2052, Australia
*
Authors to whom correspondence should be addressed.
Academic Editors: Michele Fiore and Emiliano Altamura
Life 2021, 11(12), 1413; https://doi.org/10.3390/life11121413
Received: 24 November 2021 / Revised: 10 December 2021 / Accepted: 13 December 2021 / Published: 16 December 2021
Metal ions strongly affect the self-assembly and stability of membranes composed of prebiotically relevant amphiphiles (protoamphiphiles). Therefore, evaluating the behavior of such amphiphiles in the presence of ions is a crucial step towards assessing their potential as model protocell compartments. We have recently reported vesicle formation by N-acyl amino acids (NAAs), an interesting class of protoamphiphiles containing an amino acid linked to a fatty acid via an amide linkage. Herein, we explore the effect of ions on the self-assembly and stability of model N-oleoyl glycine (NOG)-based membranes. Microscopic analysis showed that the blended membranes of NOG and Glycerol 1-monooleate (GMO) were more stable than pure NOG vesicles, both in the presence of monovalent and divalent cations, with the overall vesicle stability being 100-fold higher in the presence of a monovalent cation. Furthermore, both pure NOG and NOG + GMO mixed systems were able to self-assemble into vesicles in natural water samples containing multiple ions that were collected from active hot spring sites. Our study reveals that several aspects of the metal ion stability of NAA-based membranes are comparable to those of fatty acid-based systems, while also confirming the robustness of compositionally heterogeneous membranes towards high metal ion concentrations. Pertinently, the vesicle formation by NAA-based systems in terrestrial hot spring samples indicates the conduciveness of these low ionic strength freshwater systems for facilitating prebiotic membrane-assembly processes. This further highlights their potential to serve as a plausible niche for the emergence of cellular life on the early Earth. View Full-Text
Keywords: protocell; origins of life; prebiotic membranes; protoamphiphiles; metal ions; hot springs; N-acyl amino acid; analogue conditions protocell; origins of life; prebiotic membranes; protoamphiphiles; metal ions; hot springs; N-acyl amino acid; analogue conditions
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MDPI and ACS Style

Joshi, M.P.; Steller, L.; Van Kranendonk, M.J.; Rajamani, S. Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies. Life 2021, 11, 1413. https://doi.org/10.3390/life11121413

AMA Style

Joshi MP, Steller L, Van Kranendonk MJ, Rajamani S. Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies. Life. 2021; 11(12):1413. https://doi.org/10.3390/life11121413

Chicago/Turabian Style

Joshi, Manesh Prakash, Luke Steller, Martin J. Van Kranendonk, and Sudha Rajamani. 2021. "Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies" Life 11, no. 12: 1413. https://doi.org/10.3390/life11121413

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