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  • Case Report
  • Open Access
Life2025, 15(12), 1872;https://doi.org/10.3390/life15121872 
(registering DOI)

6 December 2025

Previous studies suggest that the cortisol awakening response (CAR) shows a biphasic pattern—either an increase or a blunting—in response to exercise involving overload, potentially reflecting physiological adaptation. However, its respon...

  • Article
  • Open Access

Multiscale Segmentation-Guided Diffusion Model for CBCT-to-CT Synthesis

  • Yike Guo,
  • Yi Luo,
  • Hamed Hooshangnejad,
  • Rui Zhang,
  • Xue Feng,
  • Quan Chen,
  • Wilfred Ngwa and
  • Kai Ding
Life2025, 15(12), 1871;https://doi.org/10.3390/life15121871 
(registering DOI)

6 December 2025

To improve synthetic CT (sCT) generation from cone-beam CT (CBCT) in radiotherapy, we propose a multiscale segmentation-guided diffusion framework. The proposed model integrates anatomical priors across multiple spatial resolutions through a segmenta...

  • Article
  • Open Access

Impact of Preservative-Free Travoprost on Intraocular Pressure and Ocular Surface in Primary Open-Angle Glaucoma Patients

  • Minas Bakirtzis,
  • Panagiota Ntonti,
  • Eirini-Kanella Panagiotopoulou,
  • Aristeidis Konstantinidis,
  • Vangelis G. Manolopoulos,
  • George Kolios and
  • Georgios Labiris
Life2025, 15(12), 1870;https://doi.org/10.3390/life15121870 
(registering DOI)

6 December 2025

Background: The present study assesses the effectiveness and tolerability of preservative-free travoprost in patients with primary open-angle glaucoma (POAG), focusing on intraocular pressure (IOP) reduction and ocular surface health over a six-month...

  • Article
  • Open Access

Standardized and Quantitative ICG Perfusion Assessment: Feasibility and Reproducibility in a Multicentre Setting

  • Eline Feitsma,
  • Hugo Schouw,
  • Tim Hoffman,
  • Sam van Dijk,
  • Wido Heeman,
  • Jasper Vonk,
  • Floris Tange,
  • Jan Koetje,
  • Liesbeth Jansen and
  • Abbey Schepers
  • + 6 authors

5 December 2025

Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging is widely used to assess tissue perfusion, yet its subjective interpretation limits correlation with postoperative parathyroid function. To address this, the Workflow model for ICG-angio...

  • Article
  • Open Access
20 Views
10 Pages

The Role of High-Resolution Lung Computed Tomography to Distinguish Between Fibrosing Hypersensitivity Pneumonitis and Usual Interstitial Pneumonia

  • Dmitry A. Kuleshov,
  • Svetlana Yu. Chikina,
  • Galina V. Nekludova,
  • Igor E. Tyurin and
  • Sergey N. Avdeev

5 December 2025

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) caused by repeated exposure to inhaled antigens in susceptible subjects. High-resolution computed tomography (HRCT) of the lungs is the leading diagnostic method for...

  • Article
  • Open Access
17 Views
17 Pages

Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity

  • Seung Hyun Bang,
  • Soyoung Hwang,
  • Seon Young Choi,
  • Hyun Joo Kim,
  • Joo Hyung Kim,
  • Sung Ho Lee,
  • Jin Woo Lee and
  • Kuk Hui Son

5 December 2025

Spaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased epith...

  • Article
  • Open Access
32 Views
19 Pages

Lyophilized Cell-Free Supernatants of Lacticaseibacillus paracasei T0901 Isolated from Fermented Palm Sap Exhibit Antiacne and Antimelanogenic Activities in B16F10 Melanoma Cells

  • Phoomjai Sornsenee,
  • Nateelak Kooltheat,
  • Nawanwat C. Pattaranggoon,
  • Komwit Surachat,
  • Arnaud Monteil and
  • Chonticha Romyasamit

5 December 2025

Acne vulgaris is a common chronic inflammatory skin condition. Conventional acne treatments are often limited by adverse effects, driving interest in alternative therapies. This study explored the multifunctional bioactivities of a lyophilized cell-f...

  • Review
  • Open Access
30 Views
12 Pages

Laparoscopic Management of Boerhaave Syndrome: Case Series and Narrative Review

  • Floris Cristian Stănculea,
  • Andrei Razvan Stoica,
  • Claudiu Octavian Ungureanu,
  • Raul Mihailov,
  • Octav Ginghina,
  • Mircea Litescu,
  • Niculae Iordache,
  • Nicoleta Alina Mares and
  • Alexandru Iordache

5 December 2025

Boerhaave syndrome, or spontaneous rupture of the esophageal wall, is a rare condition that occurs after a violent increase in intraesophageal pressure associated with negative intrathoracic pressure after forceful vomiting or retching. Rupture, usua...

  • Article
  • Open Access
57 Views
16 Pages

Ubiquitous Expression of mPolgmut Leads to the Accumulation of Cytotoxic CD8+ T Lymphocytes in Young Mice

  • Nadezhda A. Kuznetsova,
  • Ksenia K. Kochegarova,
  • Iuliia P. Baikova,
  • Eugenii N. Korshunov,
  • Leonid A. Ilchuk,
  • Marina V. Kubekina,
  • Alexandra V. Bruter,
  • Yulia Yu. Silaeva and
  • Ekaterina A. Varlamova

5 December 2025

Age-related changes are associated with mitochondrial dysfunction, which is often caused by the accumulation of mutations in mitochondrial DNA (mtDNA). One common model of aging and age-related diseases involves mice with a mutant DNA polymerase &gam...

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Life - ISSN 2075-1729