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Life, Volume 16, Issue 2

2026 February - 156 articles

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Articles (156)

  • Systematic Review
  • Open Access

Effectiveness of Physiotherapy in Haemodialysis: Systematic Review

  • Juan Rodríguez-Mansilla,
  • Carmen Murillo-González,
  • María Jiménez-Palomares,
  • Elisa María Garrido-Ardila and
  • Blanca González-Sánchez
Life2026, 16(2), 340;https://doi.org/10.3390/life16020340 
(registering DOI)

15 February 2026

Background: Chronic kidney disease (CKD) is a progressive pathology that affects millions of people worldwide, becoming a public health challenge due to its high prevalence and mortality. In its advanced stages, patients require therapies such as hae...

  • Article
  • Open Access
Life2026, 16(2), 339;https://doi.org/10.3390/life16020339 
(registering DOI)

15 February 2026

The severity of cardiovascular disease is linked to C-reactive protein, interleukin 6, and C-type natriuretic peptide levels, stressing the need for a sensitive sensor that can detect these biomarkers at ultralow levels in real time. Whole blood samp...

  • Article
  • Open Access

The Critical Role of Nutritional and Procedural Factors in CTO-PCI Patient Prognosis

  • Gürkan Karaca,
  • Ahmet Ekmekci,
  • Ali Kimiaei,
  • Seyedehtina Safaei,
  • Aziz İnan Çelik and
  • Metin Çağdaş
Life2026, 16(2), 338;https://doi.org/10.3390/life16020338 
(registering DOI)

15 February 2026

(1) Background: Chronic total occlusion percutaneous coronary intervention (CTO-PCI) is a complex, high-risk procedure compared to standard percutaneous coronary intervention (PCI). Scoring systems such as the Japanese Chronic Total Occlusion (J-CTO)...

  • Article
  • Open Access

Associations of Neutrophil-to-Lymphocyte Ratio with Cerebral Small Vessel Disease and Functional Outcome in Acute Ischaemic Stroke Patients

  • Nipit Tieachanpan,
  • Surat Tanprawate,
  • Atiwat Soontornpun,
  • Chayasak Wantaneeyawong,
  • Chutithep Teekaput,
  • Nopdanai Sirimaharaj,
  • Angkana Nudsasarn,
  • Withawat Vuthiwong and
  • Kitti Thiankhaw
Life2026, 16(2), 337;https://doi.org/10.3390/life16020337 
(registering DOI)

15 February 2026

Background: The relationship between inflammatory markers and cerebral small vessel disease (CSVD) in patients with acute ischaemic stroke (AIS) remains unclear. This study aimed to investigate the association between simplified inflammatory biomarke...

  • Article
  • Open Access

Biomechanical Comparison of Three Fixation Constructs for Tile Type C1.2 Pelvic Ring Fractures: A Finite Element Analysis

  • Adrian Claudiu Carp,
  • Bogdan Veliceasa,
  • Dmour Awad,
  • Alexandru Filip,
  • Mihaela Perțea,
  • Norin Forna,
  • Bogdan Puha,
  • Ștefan Dragoș Tîrnovanu,
  • Mihnea Theodor Sîrbu and
  • Paul Dan Sîrbu
  • + 1 author
Life2026, 16(2), 336;https://doi.org/10.3390/life16020336 
(registering DOI)

15 February 2026

Fractures of the pelvic ring are among the most severe injuries in orthopaedic practice and Tile type C lesions are characterized by complete disruption of the posterior arch with both vertical and rotational instability. The optimal construct for po...

  • Systematic Review
  • Open Access

A Meta-Analysis on the Long-Term Impact of Cytoreductive Surgery Plus HIPEC for Ovarian Cancer with Peritoneal Metastasis: Are We on the Right Path?

  • Dan Brebu,
  • Mircea Șelaru,
  • Ionut Flaviu Faur,
  • Mihai Cosmin Burta,
  • Ioana Adelina Faur,
  • Amadeus Dobrescu,
  • Ciprian Duță,
  • Vlad Braicu,
  • Andreea-Adriana Neamțu and
  • Danau Răzvan
Life2026, 16(2), 335;https://doi.org/10.3390/life16020335 
(registering DOI)

14 February 2026

Background: The benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery (CRS) in ovarian cancer with peritoneal metastasis remains debated outside selected indications. We performed a systematic review and meta-an...

  • Article
  • Open Access

Which Training Is More Effective in Post-COVID-19 Geriatric Patients with COPD: Cycle Ergometer Interval Training or Continuous Training?

  • Katarzyna Bogacz,
  • Jacek Łuniewski,
  • Anna Szczegielniak,
  • Danuta Lietz-Kijak and
  • Jan Szczegielniak
Life2026, 16(2), 334;https://doi.org/10.3390/life16020334 
(registering DOI)

14 February 2026

Introduction: Respiratory rehabilitation programs for geriatric patients with chronic obstructive pulmonary disease (COPD) after COVID-19 require a precise assessment of needs and an individualized approach. However, there is a lack of specific recom...

  • Correction
  • Open Access

Correction: Assani et al. Beyond HOMA-IR: Comparative Evaluation of Insulin Resistance and Anthropometric Indices Across Prediabetes and Type 2 Diabetes Mellitus in Metabolic Syndrome Patients. Life 2025, 15, 1845

  • Mohamed-Zakaria Assani,
  • Lidia Boldeanu,
  • Anda Lorena Dijmărescu,
  • Daniel Cosmin Caragea,
  • Ionela Mihaela Vladu,
  • Diana Clenciu,
  • Adina Mitrea,
  • Alexandra-Ștefania Stroe-Ionescu,
  • Mariana-Emilia Caragea and
  • Mihail Virgil Boldeanu
  • + 1 author
Life2026, 16(2), 333;https://doi.org/10.3390/life16020333 
(registering DOI)

14 February 2026

In the original publication [...]

  • Systematic Review
  • Open Access
Life2026, 16(2), 332;https://doi.org/10.3390/life16020332 
(registering DOI)

14 February 2026

Transoral robotic surgery (TORS) offers a targeted surgical option for addressing base of tongue (BOT) and epiglottic obstruction in selected obstructive sleep apnoea (OSA) cases; however, most published evidence evaluates TORS within multilevel appr...

  • Article
  • Open Access

Early Changes in Renal Function as Predictors of In-Hospital Mortality in COVID-19 Patients

  • Nicu Olariu,
  • Nilima Rajpal Kundnani,
  • Simona Ruxanda Dragan,
  • Luciana-Elena Marc,
  • Victor Buciu,
  • Delia Mira Berceanu Vaduva,
  • Andreas Valcovici,
  • Ioana Adela Ratiu,
  • Petru Bucuras and
  • Adelina Mihaescu
Life2026, 16(2), 331;https://doi.org/10.3390/life16020331 
(registering DOI)

14 February 2026

Background: Acute kidney injury (AKI) is a frequent and prognostically relevant complication of COVID-19. However, reliance on static creatinine values or binary AKI definitions may overlook clinically meaningful early renal dynamics. We evaluated wh...

  • Systematic Review
  • Open Access

Fats and Facts: A Meta-Analysis of Lipid Biomarkers in Endometrial Cancer

  • Ioana Adelina Clim,
  • Ionut Flaviu Faur,
  • Catalin Prodan-Barbulescu,
  • Andreea-Adriana Neamtu,
  • Paul Pasca,
  • Cosmin Burta,
  • Sergiu Florin Bara,
  • Dan Brebu,
  • Vlad Braicu and
  • Amadeus Dobrescu
  • + 3 authors
Life2026, 16(2), 330;https://doi.org/10.3390/life16020330 
(registering DOI)

14 February 2026

Background: Endometrial cancer (EC) represents one of the most prevalent gynecological malignancies worldwide, with increasing incidence rates attributed to rising obesity, metabolic syndrome, and demographic aging. Recent evidence suggests that dysl...

  • Article
  • Open Access
13 Views
20 Pages

13 February 2026

Background: Environmental agents can disrupt thyroid function at several levels, including the synthesis, action, and excretion of thyroid hormones, and an inadequate concentration of thyroid hormones affects almost all organs and systems. Objective:...

  • Article
  • Open Access
39 Views
23 Pages

Improving the Prediction of Radiation Pneumonitis: Leveraging Radiomics and Dosiomics Within IDLSS Lung Subregions

  • Tsair-Fwu Lee,
  • Wen-Ping Yun,
  • Ling-Chuan Chang-Chien,
  • Hung-Yu Chang,
  • Yi-Lun Liao,
  • Ya-Shin Kuan,
  • Chiu-Feng Chiu,
  • Cheng-Shie Wuu,
  • Yang-Wei Hsieh and
  • Pei-Ju Chao
  • + 3 authors

13 February 2026

Purpose: This study develops a predictive model for radiation pneumonitis (RP) risk in lung cancer patients after volume-modulated arc therapy (VMAT) that leverages high-dimensional dosiomics and dose–volume histogram (DVH) features within IDLS...

  • Article
  • Open Access
38 Views
19 Pages

13 February 2026

Objectives: Cerebral ischemia/reperfusion (IR) injury is characterized by excessive oxidative stress and activation of apoptotic pathways, which play a central role in neuronal loss and poor neurological outcomes. Modulation of these mechanisms repre...

  • Review
  • Open Access
44 Views
39 Pages

13 February 2026

Despite decades of interventions targeting modifiable risk factors to reduce the burden of cardiovascular disease, ischemic heart disease (IHD) remains the leading cause of mortality and the second leading cause of disability-adjusted life-years worl...

  • Article
  • Open Access
47 Views
16 Pages

Microvascular Dysfunction in Patients with Prediabetes: Novel Methods Identify Impaired Microcirculation

  • Stamatina Lamprou,
  • Nikolaos Evangelidis,
  • Nikolaos Koletsos,
  • Ioanna Zografou,
  • Anastasia Stoimeni,
  • Gesthimani Mintziori,
  • Vasileios Gkolias,
  • Christina-Maria Trakatelli,
  • Christos Savopoulos and
  • Areti Triantafyllou
  • + 1 author

13 February 2026

Background: Skin and myocardial microvascular dysfunction in prediabetes remains underexplored, and limited studies have investigated the microcirculation in prediabetes in multiple vascular beds. This study aimed to examine microvascular alterations...

  • Article
  • Open Access
41 Views
12 Pages

Transthoracic Echocardiography as a Tool for Early Detection of Atrial Fibrillation in Patients Receiving Ibrutinib

  • Vittoria Gammaldi,
  • Martina Pucci,
  • Francesca La Rocca,
  • Pasquale Megaro,
  • Daniele Paoletta,
  • Mariateresa Pontoriero,
  • Luca Maria Capece,
  • Roberto Luise,
  • Marina Iacono and
  • Roberta Esposito

13 February 2026

Background: Bruton’s tyrosine kinase inhibitors, particularly ibrutinib, have improved outcomes in patients with chronic lymphocytic leukemia but are associated with an increased risk of atrial fibrillation. The early identification of patients...

  • Review
  • Open Access
69 Views
16 Pages

Cardiopulmonary Complications in Obese Patients with Gynecologic Cancer: A Narrative Review

  • Maria Fanaki,
  • Nikolaos Thomakos,
  • Vasileios Lygizos,
  • Antonia Varthaliti,
  • Dimitrios Haidopoulos,
  • Dimitrios Efthimios Vlachos and
  • Vasileios Pergialiotis

13 February 2026

Gynecologic cancer is a major global health burden, and improvements in screening, surgical techniques, and systemic therapies have significantly prolonged survival. As a result, cardiopulmonary disease has emerged as a leading non-cancer cause of mo...

  • Review
  • Open Access
114 Views
19 Pages

Nano-Enabled Herbal Remedies for Malaria Treatment: A Review of Recent Advances

  • Chang Xu,
  • Arooj Fatima,
  • Mahreen Fatima,
  • Amjad Islam Aqib,
  • Tean Zaheer,
  • Safia Obaidur Rab,
  • Mohd Saeed,
  • Zeeshan Arif and
  • Kun Li

12 February 2026

Malaria has long been a significant global health concern, listed as a high-priority disease by several global health agencies, despite of several control measures have been put in place. Most widely utilized treatment options for malaria include chl...

  • Article
  • Open Access
78 Views
13 Pages

Effect of Oxidative Stress Intensity on Inflammatory, Bone Turnover, and Haemostasis Biomarkers in Patients with Spinal Osteoarthritis

  • Milan Mirković,
  • Jelena Vekić,
  • Nataša Bogavac-Stanojević,
  • Jelena Kotur-Stevuljević,
  • Neda Milinković,
  • Anđelka Milić,
  • Sanja Mirković,
  • Ankica Vujović,
  • Zoran Baščarević and
  • Biljana Božić Nedeljković

12 February 2026

Osteoarthritis is associated with chronic inflammation, which contributes to a hypercoagulable state. Oxidative stress may further disrupt homeostatic balance, thereby promoting thrombotic events. This study evaluated the association between biomarke...

  • Article
  • Open Access
89 Views
20 Pages

Can Non-Conventional Blood Biomarkers Improve Running Performance Prediction? A Proof of Concept

  • Matija Dvorski,
  • Marija Rakovac,
  • Tomislav Kelava,
  • Nataša Kovačić,
  • Darja Flegar,
  • Sara Aničić,
  • Ivo Krešić,
  • Ljiljana Ćulibrk,
  • Filip Koražija and
  • Alan Šućur
  • + 1 author

12 February 2026

Conventional measures such as maximal oxygen uptake (V˙O2max), although widely regarded as the gold standard, do not fully capture endurance performance. Therefore, this study investigated whether a 2.4 km Cooper test elicits measurable changes...

  • Review
  • Open Access
75 Views
15 Pages

Light-Controlled Membrane Fusion in Synthetic Cells

  • Boying Xu,
  • Adriano Caliari and
  • Jian Xu

12 February 2026

Light-induced membrane fusion has become a pivotal technique for constructing and functionalizing synthetic cells by enabling precise control over membrane merging events. Traditional fusion approaches that rely on chemical, physical, and mechanical...

  • Article
  • Open Access
260 Views
13 Pages

Arrhythmias as Part of Long COVID Syndrome in Hospitalized Patients That Survived a Severe COVID-19 Infection and the Potential Protective Role of Metformin in These Patients

  • Haydee Ninette Morales-Vazquez,
  • David Cardona-Müller,
  • Fernando Grover-Paez,
  • Carlos Gerardo Ramos-Becerra,
  • Ernesto Germán Cardona-Muñoz,
  • Maria Guadalupe Ramos-Zavala,
  • Jaime Carmona-Huerta,
  • Jorge Eduardo Hernandez-del-Rio,
  • Tomas Miranda-Aquino and
  • Christopher Josue Lopez-Gradilla
  • + 1 author

12 February 2026

Background: Cardiac arrhythmias are a frequent complication of acute SARS-CoV-2 infection. However, their long-term prevalence and clinical determinants among patients with post-COVID-19 syndrome, especially those previously hospitalized, remain poor...

  • Review
  • Open Access
246 Views
25 Pages

12 February 2026

5-Aminolevulinic acid (5-ALA) is a naturally occurring heme precursor with a favorable safety profile and is widely used for fluorescence-guided resection of malignant gliomas. Exogenous administration of 5-ALA results in the selective intracellular...

  • Case Report
  • Open Access
105 Views
9 Pages

Transcatheter Correction of Bilateral Partial Anomalous Pulmonary Venous Return with Intrapulmonary Dual Drainage: A Rare Entity

  • Dusan Andric,
  • Andrija Pavlovic,
  • Igor Stefanovic,
  • Marko Pavlovic,
  • Maja Trkulja,
  • Maja Bijelic,
  • Milica Kuzmanovic,
  • Jovan Petrovic,
  • Mirko Topalovic and
  • Milan Djukic
  • + 1 author

12 February 2026

Partial anomalous pulmonary venous return (PAPVR) with dual drainage is a very rare congenital heart anomaly. We report the case of a 6-year-old boy with PAPVR in whom both upper pulmonary veins (PVs) drain anomalously into the systemic venous circul...

  • Article
  • Open Access
107 Views
22 Pages

12 February 2026

Background: Clozapine (CLZ) is an atypical antipsychotic mainly prescribed for treatment-resistant schizophrenia. Beyond psychotic symptoms, patients often exhibit persistent cognitive impairments across domains such as attention, learning, and memor...

  • Hypothesis
  • Open Access
145 Views
23 Pages

Microvascular Genesis of Diseases: From Hypothesis to Theory

  • Ruslan A. Nasyrov,
  • Veronika A. Galichina,
  • Anna O. Drobintseva,
  • Daria V. Tonkonog,
  • Elena Yu. Kalinina and
  • Alexandra A. Agafonnikova

11 February 2026

Despite progress in understanding the molecular mechanisms of diseases, the dominant paradigm in explaining pathogenesis remains the concept of a pathogen’s direct damaging effect on parenchymal cells. Based on years of research, the authors of...

  • Case Report
  • Open Access
128 Views
11 Pages

Severe HAPE in a Remote High-Altitude Research Station in Antarctica

  • Fanny Larcher,
  • Paul Laforet,
  • Stephane Fraize,
  • Mario Lecca,
  • Riccardo Scipinotti,
  • Gianluca Bianchi Fasani,
  • Salvatore Vagnoni and
  • Sascha Freigang

11 February 2026

Isolated, confined, and extreme environments hold the opportunity to collect unique biomedical data. These often-remote places present specific medical challenges for deployed expeditioners. Here we report a case of acute severe high altitude pulmona...

  • Article
  • Open Access
109 Views
13 Pages

Concomitant Venous Disease in Patients with Advanced Peripheral Arterial Disease: A Patient- and Limb-Level Analysis

  • Daniela Marinescu,
  • Laurențiu Augustus Barbu,
  • Tiberiu Stefăniță Țenea Cojan,
  • Ștefan Pătrascu,
  • Marius Bică,
  • Răzvan Alexandru Marinescu,
  • Sarmis Marian Săndulescu,
  • Valeriu Șurlin and
  • Ana-Maria Ciurea

11 February 2026

Background: Advanced stages of peripheral arterial disease, particularly chronic limb-threatening ischemia, are characterized by unfavorable limb outcomes and a substantial risk of major amputation. Clinical evaluation traditionally focuses on arteri...

  • Article
  • Open Access
195 Views
12 Pages

Increased Risk of Recurrent Ischemic Stroke in Male Patients Taking Medications for Benign Prostatic Hyperplasia

  • Chun-Gu Cheng,
  • Chun-Fang Chen,
  • Wu-Chien Chien,
  • Chia-Chao Wu,
  • Hung-Wen Chiu,
  • Fei-Hung Hung,
  • Hung-Pin Peng,
  • Chi-Hsiang Chung and
  • Chun-An Cheng

11 February 2026

Background: Patients with benign prostatic hyperplasia (BPH) have an increased risk of developing cardiovascular disease. Taking alpha-1 blockers is associated with an increased risk of major adverse cardiovascular events. Patients suffering from isc...

  • Review
  • Open Access
107 Views
25 Pages

Obesity, Metabolic Syndrome and MASLD in Children: Inflammation as the Missing Link—A Short Narrative Review

  • Mihaela-Andreea Podeanu,
  • Claudiu Marinel Ionele,
  • Raluca Elena Sandu,
  • Ion Rogoveanu,
  • Mioara Desdemona Stepan,
  • Carmen Elena Niculescu,
  • Sergiu-Marian Cazacu and
  • Ștefănița Bianca Vintilescu

11 February 2026

Childhood obesity has emerged as a major global health challenge, with a marked increase in prevalence. Defined by excessive fat accumulation, it is associated with an increased risk of developing metabolic syndrome (MetS) and metabolic dysfunction-a...

  • Review
  • Open Access
118 Views
17 Pages

Advancing Prenatal Diagnosis: From Conventional Karyotyping to Genome-Wide CNV Analysis

  • Elitsa Gyokova,
  • Eleonora Hristova-Atanasova,
  • Elizabeth Odumosu and
  • Kamelia Dimitrova

11 February 2026

Background: Advances in genome-wide DNA-based technologies have fundamentally transformed prenatal genetic diagnostics, enabling detection of clinically significant submicroscopic chromosomal abnormalities that are not identifiable by conventional cy...

  • Editorial
  • Open Access
171 Views
8 Pages

The Cardiovascular Disease Continuum: From Cardiovascular Risk Factors to Heart Failure

  • Mariana Floria,
  • Anca Victorita Trifan and
  • Daniela Maria Tanase

11 February 2026

Over the past 30 years, cardiovascular diseases (CVD) have become the dominant contributor to the global disease burden, accounting for approximately 93% of prevalence, 54% of mortality, and 60% of disability-adjusted life-years lost [...]

  • Article
  • Open Access
281 Views
15 Pages

10 February 2026

Despite the global increase in cat ownership, some cats exhibit owner-directed aggression, resulting in caregiver injury, infection, and anxiety. Severe cases are commonly treated with selective serotonin reuptake inhibitors such as fluoxetine; howev...

  • Systematic Review
  • Open Access
183 Views
17 Pages

Mirror Therapy Versus Motor Imagery in Stroke Neurorehabilitation: A Systematic Review with Comparative Narrative Synthesis

  • Luis Polo-Ferrero,
  • Javier Torres-Alonso,
  • Juan Luis Sánchez-González,
  • Sara Hernández-Rubia,
  • Arturo Dávila-Marcos,
  • María Agudo Juan,
  • Javier Oltra-Cucarella and
  • Rubén Pérez-Elvira

10 February 2026

Background: Motor imagery (MI) and mirror therapy (MT) are widely used neurorehabilitation strategies to enhance motor recovery after stroke and are commonly applied as adjuncts to conventional rehabilitation therapy (CRT). However, direct comparativ...

  • Review
  • Open Access
128 Views
26 Pages

Adipose Tissue Circadian Dysregulation Beyond BMI: Implications for Cardiometabolic Risk and Cardiovascular Disease

  • Maria-Daniela Tanasescu,
  • Andrei-Mihnea Rosu,
  • Alexandru Minca,
  • Maria-Mihaela Grigorie,
  • Delia Timofte and
  • Dorin Ionescu

10 February 2026

Cardiometabolic and cardiovascular risks are commonly assessed using body mass index (BMI) and static measures of adiposity; however, individuals with similar BMI frequently exhibit markedly different metabolic and cardiovascular outcomes. This heter...

  • Article
  • Open Access
155 Views
15 Pages

10 February 2026

(1) Introduction. To improve access times and provide effective treatment to the growing patient population with acute stroke due to large vessel occlusion (LVO), thrombectomy-capable stroke centers (TCSCs) should be made an integral part of hospital...

  • Article
  • Open Access
125 Views
16 Pages

SWAU-Net: Longitudinal Prediction of Geographic Atrophy via Sliding-Window Attention

  • Peter Racioppo,
  • Ziyuan Chris Wang,
  • SriniVas R. Sadda and
  • Zhihong Jewel Hu

10 February 2026

Age-related macular degeneration (AMD) is the leading cause of central vision loss in aging populations. Geographic atrophy (GA) is the advanced, non-neovascular form of AMD. Predicting the longitudinal progression of GA remains a critical challenge...

  • Review
  • Open Access
139 Views
26 Pages

Applications of Nanobiotechnology in Medicine

  • David Aebisher,
  • Klaudia Dynarowicz,
  • Izabela Rudy,
  • Kacper Rogóż,
  • Dorota Bartusik-Aebisher and
  • Aleksandra Kawczyk-Krupka

10 February 2026

Nanobiotechnology, defined as the application of nanotechnology in biology and medicine, refers to the use of nanometric structures to solve complex clinical problems through precise interaction at the molecular level. Nanostructures such as lipid, p...

  • Article
  • Open Access
212 Views
15 Pages

10 February 2026

Phylogenetic metrics can separate two complementary biodiversity dimensions: the amount of evolutionary history retained in a community (Faith’s phylogenetic diversity, PD) and community assembly signals expressed as departures from null expect...

  • Article
  • Open Access
141 Views
22 Pages

Foodomics of Rice Grains in Astrobiology: Spaceflight-Induced Modulation of Aroma, Texture, and Protein Digestibility in Thai Landrace Rice (466HM) Aboard the Shijian-19 (SJ-19) Low Earth Orbit Mission

  • Tatpong Tulyananda,
  • Yodying Yingchutrakul,
  • Kakanang Tantraphongsathon,
  • Atiggamas Khamsuwan,
  • Peerapon Moung-Ngam,
  • Phanchita Vejchasarn,
  • Phakorn Papan,
  • Jakkaphan Kumsab,
  • Chutikarn Butkinaree and
  • Sucheewin Krobthong
  • + 4 authors

10 February 2026

Ensuring a sustainable source of nutritious food is critical for long-duration space missions. Thai landrace rice 466HM exhibits high nutritional value and stress resilience, making it a promising candidate for space cultivation, yet its response to...

  • Article
  • Open Access
154 Views
17 Pages

Brainstem Raphe Echogenicity and Insomnia in Type 2 Diabetes: An Exploratory Cross-Sectional Study

  • Maarja Randväli,
  • Kaja Mädamürk,
  • Jekaterina Šteinmiller and
  • Toomas Toomsoo

9 February 2026

Background: Type 2 diabetes mellitus (T2DM) is associated with increased vulnerability to depression and other affective disturbances, potentially mediated by neurobiological alterations in the serotonergic brainstem raphe nuclei. This study examined...

  • Article
  • Open Access
168 Views
14 Pages

Gut Microbial Diversity and Community Structure Are Largely Similar Between Apparently Healthy Elderly Japanese Males and Females: A Shotgun Metagenomic Study

  • M. H. Mahbub,
  • Ryosuke Hase,
  • Natsu Yamaguchi,
  • Yoshiyuki Asai,
  • Masanori Harada,
  • Naoyuki Ichimura,
  • Yoshihiro Hayakawa,
  • Yusuke Inohana,
  • Yutaka Umakoshi and
  • Tsuyoshi Tanabe
  • + 11 authors

9 February 2026

Sex differences in gut microbiota may affect health and aging, but evidence in elderly populations is limited and inconsistent. This study examined sex-specific similarities and differences in gut microbiota diversity and composition among apparently...

  • Review
  • Open Access
168 Views
30 Pages

Neurodegeneration Biomarkers in Epilepsy: A Critical Review of Current Findings

  • Ambra Butera,
  • Simona D’Antoni,
  • Antonio Gennaro Nicotera,
  • Maria Vincenza Catania,
  • Carla Consoli,
  • Graziana Ceraolo,
  • Giulia Spoto,
  • Maria Ludovica Albertini,
  • Gabriella Di Rosa and
  • Maurizio Elia

9 February 2026

Developmental and epileptic encephalopathies (DEEs) represent the most severe group of epilepsies, characterized by drug-resistant seizures, frequent occurrence of epileptiform activity, developmental delay or cognitive impairment. Recent insights ha...

  • Review
  • Open Access
214 Views
19 Pages

The Fibrotic–Cancer Continuum in IPF: Shared Mechanisms, Clinical Implications and Therapeutic Challenges

  • Panagiota Tsiri,
  • Marousa Kouvela,
  • Ourania Papaioannou,
  • Vasilina Sotiropoulou,
  • Matthaios Katsaras,
  • Nikolaos Syrigos,
  • Fotios Sampsonas and
  • Argyrios Tzouvelekis

9 February 2026

Idiopathic pulmonary fibrosis represents a chronic, progressive, lethal lung disease of various etiologies exerting a dramatic impact on patients’ survival and quality of life. Its increasing prevalence and high mortality rates indicate the imp...

  • Review
  • Open Access
293 Views
31 Pages

The Oral Microbiome and Systemic Health: Current Insights into the Mouth–Body Connection

  • Ana Glavina,
  • Dora Martić,
  • Marija Ana Perko,
  • Dora Mešin Delić,
  • Antonija Tadin,
  • Stjepanka Lešić and
  • Daniela Šupe-Domić

9 February 2026

The oral cavity contains a complex and dynamic microbial ecosystem that plays a central role in maintaining both local and systemic homeostasis. Emerging evidence indicates that disturbances in oral microbial communities-including genetic and functio...

  • Review
  • Open Access
178 Views
18 Pages

9 February 2026

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke, are among the most devastating neurological disorders worldwide. Glioblastoma (GBM) is a rapidly growing cancer that originates in astro...

  • Case Report
  • Open Access
196 Views
12 Pages

Percutaneous Closure of a Large-Bore Carotid Arteriotomy Using a Collagen-Based Vascular Plug

  • Radoslaw Parma,
  • Radoslaw Gocol,
  • Joanna Nawara-Skipirzepa,
  • Ryszard Bachowski,
  • Wojciech Wojakowski and
  • Damian Hudziak

9 February 2026

Background: Inadvertent arterial cannulation during central venous catheter placement is a recognized complication with potentially serious consequences, particularly when involving large-caliber catheters. While management strategies have evolved fr...

  • Review
  • Open Access
193 Views
23 Pages

8 February 2026

Kidney disease is a growing global public health challenge that accounts for substantial morbidity, premature mortality, and rising healthcare costs. Although diabetes mellitus and hypertension remain the principal clinical risk factors for renal inj...

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Life - ISSN 2075-1729