Symmetry, Volume 12, Issue 4
2020 April - 193 articles
Cover Story: The most studied nonenzymatic spontaneous mechanisms of protein aging include oxidation, deamidation, glycation, and isomerization/racemization of specific AA residues. Isomerization and racemization represent distinct forms of spontaneous PTMs (PTMs Sp) that occur without changing the chemical contents but, rather, the symmetry patterns. Initial PTM Sp leads to the accumulation of long-lived macromolecular aggregates, which are the subject of further age-related spontaneous racemization. Protein aging becomes organism aging through the occurrence of corresponding cell physiology events. The accumulation and condensation of damaged proteins accelerates the process of protein aging. View this paper. - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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