Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 694

Special Issue Editor


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Guest Editor
Department V of Internal Medicine I, Discipline of Internal Medicine IV, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania
Interests: digestive oncology; immunotherapy; angiogenesis
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Special Issue Information

Dear Colleagues,

This Special Issue, “Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions”, will explore the evolving landscape of neoadjuvant treatments for hepatopancreatobiliary cancers, including hepatocellular carcinoma, pancreatic cancer, and cholangiocarcinoma. Neoadjuvant therapy, encompassing chemotherapy, radiotherapy, immunotherapy, and targeted approaches, plays a critical role in improving surgical outcomes and survival rates in these challenging malignancies. For this Special Issue, we invite the submission of original research articles, reviews, and clinical studies that address current advancements, novel therapeutic strategies, and the molecular mechanisms underlying treatment responses. Contributions should focus on the latest clinical trials, treatment protocols, biomarkers for predicting efficacy, and emerging personalized treatment approaches. The goal is to provide a comprehensive update on both established and experimental therapies, highlighting future directions in neoadjuvant treatment in these cancers.

Dr. Daniela Cornelia Lazăr
Guest Editor

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Keywords

  • neoadjuvant therapy
  • hepatopancreatobiliary malignancies
  • hepatocellular carcinoma
  • pancreatic cancer
  • cholangiocarcinoma
  • chemotherapy
  • radiotherapy
  • immunotherapy
  • targeted therapies
  • personalized treatment

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Published Papers (1 paper)

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Research

14 pages, 1208 KiB  
Article
Efficacy of Conversion Surgery for Initially Unresectable Biliary Tract Cancer That Has Responded to Down-Staging Chemotherapy
by Takashi Murakami, Ryusei Matsuyama, Yasuhiro Yabushita, Yuki Homma, Yu Sawada, Kentaro Miyake, Takafumi Kumamoto, Kazuhisa Takeda, Shin Maeda, Shoji Yamanaka and Itaru Endo
Cancers 2025, 17(5), 873; https://doi.org/10.3390/cancers17050873 - 3 Mar 2025
Viewed by 584
Abstract
Background: Due to the limited efficacy of chemotherapy alone in the treatment of unresectable biliary tract cancer, we performed conversion surgery in patients with unresectable biliary tract cancer who responded to down-staging chemotherapy. Methods: Patients with unresectable biliary tract cancer who initiated chemotherapy [...] Read more.
Background: Due to the limited efficacy of chemotherapy alone in the treatment of unresectable biliary tract cancer, we performed conversion surgery in patients with unresectable biliary tract cancer who responded to down-staging chemotherapy. Methods: Patients with unresectable biliary tract cancer who initiated chemotherapy between 2007 and 2018 were included in this study. We evaluated the short- and long-term outcomes of patients with initially unresectable biliary tract cancer who underwent conversion surgery. Results: A total of 101 patients with unresectable biliary tract cancers treated with chemotherapy were eligible for the present study. A total of 20 patients eventually underwent conversion surgery; these patients had locally advanced disease in 6 cases, liver metastasis in 6 cases, para-aortic lymph node metastasis in 5 cases, and peritoneal dissemination in 3 cases. The mean operative time was 823 min, and the mean intraoperative blood loss was 1902 mL. Histological R0 resections were performed in 17 patients. Postoperative complications of Clavien–Dindo grade IIIa or higher occurred in 10 patients, with no surgery-associated deaths. The 5-year survival rate was significantly higher in patients who underwent conversion surgery (65.0%) than in those who did not (4.3%, p < 0.001). Conclusions: Conversion surgery for initially unresectable biliary tract cancer resulted in favorable overall survival and was safely performed despite its high surgical invasiveness. Conversion surgery for an initially unresectable biliary tract cancer is worth considering. Full article
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